Industrial Transformation Training Centres - Grant ID: IC180100024
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, internatio ....ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, international collaborations and a generation of industry-ready researchers critical for growing Australia’s industry. The advances in materials and savings in time for procedures will reduce costs.
Read moreRead less
Encoding Interactions and Printability into Hairy Colloidal Biomaterials. Printing mixtures of live cells and biomaterials (or 'BioInks') to make bespoke engineered tissues has the potential to enable personalised platforms for therapeutic discovery and organ replacement. Using a novel high throughput approach to materials synthesis, BioInk design and process optimisation, this project aims to discover new biomaterials and printing nozzles to help realise this potential. It will produce new insi ....Encoding Interactions and Printability into Hairy Colloidal Biomaterials. Printing mixtures of live cells and biomaterials (or 'BioInks') to make bespoke engineered tissues has the potential to enable personalised platforms for therapeutic discovery and organ replacement. Using a novel high throughput approach to materials synthesis, BioInk design and process optimisation, this project aims to discover new biomaterials and printing nozzles to help realise this potential. It will produce new insights in colloid science, cell-laden biomaterials design, and BioInk processing. Structure-property-function guides for colloid-based BioInks and quality-assured bioprinting as outcomes represent significant benefits for researchers and industries alike engaged in biofabrication, cell therapy and biotherapeutics.Read moreRead less
The Material Science of Biomimetic Soft Network Composites. Nature combines stiff and strong collagen fibres intertwined within a weak polymer matrix of proteoglycans into soft tissues with outstanding mechanical durability and biological properties. We converge a biomimetic design strategy inspired in the architecture of natural soft tissues and a novel additive manufacturing technology termed melt electrowriting (MEW) to manufacture advanced biomimetic soft network composites (BSNC). The SNCs ....The Material Science of Biomimetic Soft Network Composites. Nature combines stiff and strong collagen fibres intertwined within a weak polymer matrix of proteoglycans into soft tissues with outstanding mechanical durability and biological properties. We converge a biomimetic design strategy inspired in the architecture of natural soft tissues and a novel additive manufacturing technology termed melt electrowriting (MEW) to manufacture advanced biomimetic soft network composites (BSNC). The SNCs are composed of a weak polymer matrix and a MEW reinforcing fibrous phase printed at the nanometre scale, containing patterns mimicking the natural tissue architectures. Advanced computational tools are applied for the rational design of the SNC while reducing costs and times associated to experimental work.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100128
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Engineering microenvironments to regulate osteocyte 3D networks in vitro. Most knowledge of bone is based on only a fraction of cells found in bone because the majority of cells in our bones (called osteocyte cell networks) cannot easily be grown or studied outside the body. This results in the inability to understand how the bone organ functions. Using bioinspired engineering, this project will use advanced biomaterials to biofabricate, for the first time, osteocyte cell networks in vitro. By u ....Engineering microenvironments to regulate osteocyte 3D networks in vitro. Most knowledge of bone is based on only a fraction of cells found in bone because the majority of cells in our bones (called osteocyte cell networks) cannot easily be grown or studied outside the body. This results in the inability to understand how the bone organ functions. Using bioinspired engineering, this project will use advanced biomaterials to biofabricate, for the first time, osteocyte cell networks in vitro. By unravelling how they are formed and controlled by manipulating their microenvironment, we will discover how different types of bones are formed. The benefits will be a valuable tool for the bone research community, allowing unresolved questions to be addressed in the future, such as how bone forms, repairs, and remodels.Read moreRead less
A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include th ....Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include the establishment of a new multidisciplinary research team, and the development of a new data-driven theoretical framework for understanding the nature and the causes of age-related bone fragility. Potential long-term benefits include new ways to treat age-related osteoporosis.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less