The deep history of Sea Country: Climate, sea level and culture. This project aims to investigate the records of the now-submerged Pilbara coast (50,000 to 7000 years ago). Nearly a third of Australia’s landmass was drowned after the last ice age, and sea-level change displaced generations of people. Submerged landscape archaeology will help reveal past sea-level rise, population resilience, mobility and diet. The project integrates cultural and environmental studies and material analysis, and a ....The deep history of Sea Country: Climate, sea level and culture. This project aims to investigate the records of the now-submerged Pilbara coast (50,000 to 7000 years ago). Nearly a third of Australia’s landmass was drowned after the last ice age, and sea-level change displaced generations of people. Submerged landscape archaeology will help reveal past sea-level rise, population resilience, mobility and diet. The project integrates cultural and environmental studies and material analysis, and adapts a method from the world’s only confirmed submarine middens. It will use marine and aerial survey techniques to investigate physical and cultural submerged landscapes. This project expects to influence heritage and environmental management and the marine heritage sector.Read moreRead less
Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Multifunctional Structural Panels for Next-generation Infrastructure. This project aims to develop a multifunctional prefabricated structural panel for current and future infrastructure applications for both land and offshore environments. Prefabrication enables enhanced product control as well as the ability to rapidly construct whole structures or their components. The panels utilise an inner lightweight foam and fibre-reinforced polymer (FRP) composite core with strong outer panels made from ....Multifunctional Structural Panels for Next-generation Infrastructure. This project aims to develop a multifunctional prefabricated structural panel for current and future infrastructure applications for both land and offshore environments. Prefabrication enables enhanced product control as well as the ability to rapidly construct whole structures or their components. The panels utilise an inner lightweight foam and fibre-reinforced polymer (FRP) composite core with strong outer panels made from FRP sheets and high-strength concrete. The expected outcomes include experimental and numerical validation of the system, that will give designers and asset owners the confidence to adopt this new panel. The panel system presents an upward step change in construction technology and built infrastructure performance.Read moreRead less
Mitigating Vehicular Crashes into Masonry Buildings . Around 2000 vehicles crash annually into school, home and shop buildings located at close proximity to heavily trafficked roads in Australia and cause significant distress to occupants of building and vehicle. The impacted walls mostly of masonry, suffer severe damage often with vehicle intrusion into the building. Despite this, the intrusion mechanism is not understood and no effective mitigation strategies exist at present. This project wi ....Mitigating Vehicular Crashes into Masonry Buildings . Around 2000 vehicles crash annually into school, home and shop buildings located at close proximity to heavily trafficked roads in Australia and cause significant distress to occupants of building and vehicle. The impacted walls mostly of masonry, suffer severe damage often with vehicle intrusion into the building. Despite this, the intrusion mechanism is not understood and no effective mitigation strategies exist at present. This project will uncover the mechanics of vehicle intrusions through masonry walls and develop novel mitigation strategies using high energy absorbing auxetic composite render and innovative vibration isolation at wall edges. These innovations will lead to new theories that can save lives in the building and vehicle.Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
The virtual human knee. This project aims to investigate the Virtual Human Knee (VHK) which provides a baseline knowledge about knee mechanics in healthy individuals and a tool for studying knee mechanics in silico. The new knowledge can be used for identifying individuals most at risk for injury, developing solutions for preventing injury and for assessing knee reconstruction and implantation methods. As such, VHK will mitigate the burden of knee injury to Australia and worldwide by progressing ....The virtual human knee. This project aims to investigate the Virtual Human Knee (VHK) which provides a baseline knowledge about knee mechanics in healthy individuals and a tool for studying knee mechanics in silico. The new knowledge can be used for identifying individuals most at risk for injury, developing solutions for preventing injury and for assessing knee reconstruction and implantation methods. As such, VHK will mitigate the burden of knee injury to Australia and worldwide by progressing disciplines including anatomy, bio-mechanics, sport science, rehabilitation, surgery and medical devices.Read moreRead less
Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Ex ....Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Expected outcomes and benefits include new fundamental understanding of the effect of particle mechanical properties on cell function, new insights into T cell activation and expansion, and new classes of stiffness-tunable fit-for-purpose materials for various applications in cell manufacturing.Read moreRead less
Production of Biodegradable Polyhydroxyalkanoate Polymers using Advanced Biological Wastewater Treatment Process Technology. The aim of this project is to develop a sustainable process for producing biodegradable polyhydroxyalkanoate (PHAs)polymers from an innovative aerobic-anaerobic biological wastewater treatment process, ?treating? high strength food industry effluent. These biopolymers offer enormous potential for use as renewable and biodegradable thermoplastics.
It is proposed to inve ....Production of Biodegradable Polyhydroxyalkanoate Polymers using Advanced Biological Wastewater Treatment Process Technology. The aim of this project is to develop a sustainable process for producing biodegradable polyhydroxyalkanoate (PHAs)polymers from an innovative aerobic-anaerobic biological wastewater treatment process, ?treating? high strength food industry effluent. These biopolymers offer enormous potential for use as renewable and biodegradable thermoplastics.
It is proposed to investigate two process configurations, namely the sequencing batch reactor and a continuous two step anaerobic-aerobic reaction system. These will be studied at bench-scale. The outcomes include:
1. Determination of the optimum microbial conditions and key growth
parameters for the production of PHA.
2. Optimisation of the process configuration, operating strategies
and operating conditions to maximise the
production of PHA.
3. Assessment of the influence of the feed composition (e.g. VFA)
on the PHA composition (PHB/PHV).
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Transition to Customer Response Driven Networks. The project seeks to develop an electrical network costing framework that appropriately rewards customers who act to reduce network stress. The solution to the existing explosion in distribution network costs is to develop customer-responsive solutions in demand management and use of storage. The aim of this project is to develop a framework for network costs that is driven by local congestion and which would reward customer-responsive solutions. ....Transition to Customer Response Driven Networks. The project seeks to develop an electrical network costing framework that appropriately rewards customers who act to reduce network stress. The solution to the existing explosion in distribution network costs is to develop customer-responsive solutions in demand management and use of storage. The aim of this project is to develop a framework for network costs that is driven by local congestion and which would reward customer-responsive solutions. The vision is that the aggregator would provide customers with communications/control equipment that would automate the changes in the responsiveness so that customer-generated load shifting would act to limit peaks.Read moreRead less
Effective and accurate model dynamics, deterministic and stochastic, across multiple space and time scales. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells, grains) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are often known, but the closures to translate microscal ....Effective and accurate model dynamics, deterministic and stochastic, across multiple space and time scales. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells, grains) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are often known, but the closures to translate microscale knowledge to a system level macroscopic description are rarely available in closed form. Our novel methodology will explore this stumbling block, and promises to radically change the modeling, exploration and understanding of multiscale complex system behaviour.Read moreRead less