Adaptive evolution of coleoid (cuttlefish, octopus, squid) venoms. This project represents an opportunity for biodiscovery from the venoms of cuttlefish, octopuses and squids. The independent adaptation for venom active at the subzero Arctic and Antarctic polar waters is of particular evolutionary interest. However, their divergent, bioactive compounds are also a rich drug design resource.
Origin of genomically-encoded communication in animals: deciphering the role of peptide signalling in the sea sponge Amphimedon queenslandica. The purpose of this research is to understand the evolutionary origin and essential roles of peptide communication in humans and other animals. Knowledge gleaned from this study will shed light on how peptide signalling influences animal life at its most fundamental level, including potentially how abnormal cell communication causes disease.
Australian Laureate Fellowships - Grant ID: FL110100044
Funder
Australian Research Council
Funding Amount
$3,001,626.00
Summary
Origin, evolution and roles of cardinal genomic features underpinning animal multicellular complexity. As the first genome project from our oceans, the sea sponge Amphimedon heralds a new era of marine science for Australia. Using post-genomic approaches, this project will show how studying marine organisms can produce the most fundamental insights into not only multicellular life but also into human diseases and cancer that originally evolved from our oceans.
The role of toxin biosynthesis for marine dinoflagellates - an evolutionary ecological approach. Dinoflagellates are a group of microalgae that include coral symbionts and phytoplankton. Many species produce potent toxins that can be a problem in the aquaculture industry. This project will use novel genetic methods to investigate the evolution and ecology of toxin production in a variety of marine dinoflagellates.
Can lateral gene transfer lead to ecological innovation in eukaryotes? The role of saxitoxin in the diversification of Alexandrium. This project will determine the processes that led to the acquisition and diversification of the genetic basis for a potent neurotoxin, saxitoxin. This project will determine its impact on the evolution of the marine producing organisms and investigate novel genetic methods of toxin detection.