Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100175
Funder
Australian Research Council
Funding Amount
$347,070.00
Summary
Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used ....Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used to produce structures wherein living cells are spatially organised in combination with appropriate biomaterials and bioactive components, such as drugs or growth factors, in order to influence subsequent biological behaviour.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100139
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
A Hot Isostatic Press (HIP) for aerospace and biomedical component processing. This facility will provide a hot isostatic press of sufficiently large capacity to maximise production efficiencies in aerospace and biomedical applications through net shape manufacturing. The facility will be able to process small components or prototypes which will behave in a manner similar to larger scale components.
Guided droplet deposition: Microfabrication of advanced materials. The progress of micro and nanofabrication is opening an array of new opportunities with a new degree of freedom for manufacturing. This process will complement the existing micromanufacturing facilities in Melbourne. While metal printing and deposition of polymers is presently available, the guided droplet deposition will extend current capabilities to include ceramics and high melting temperature metals. Direct application to me ....Guided droplet deposition: Microfabrication of advanced materials. The progress of micro and nanofabrication is opening an array of new opportunities with a new degree of freedom for manufacturing. This process will complement the existing micromanufacturing facilities in Melbourne. While metal printing and deposition of polymers is presently available, the guided droplet deposition will extend current capabilities to include ceramics and high melting temperature metals. Direct application to medical devices will provide a more effective surface for improved performance and allow the incorporation of smart and sensor materials for multifunctional devices. Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC160100026
Funder
Australian Research Council
Funding Amount
$3,722,989.00
Summary
ARC Training Centre in Additive Biomanufacturing. ARC Training Centre in Additive Biomanufacturing. The training centre aims to bring together leading researchers and industry to develop and translate key technology platforms for personalised treatments of challenging medical conditions. The centre expects its research will lead to synergistic and innovative technologies needed for personalised therapies including: modular additive biomanufacturing platforms; advanced bio-inks for regenerative m ....ARC Training Centre in Additive Biomanufacturing. ARC Training Centre in Additive Biomanufacturing. The training centre aims to bring together leading researchers and industry to develop and translate key technology platforms for personalised treatments of challenging medical conditions. The centre expects its research will lead to synergistic and innovative technologies needed for personalised therapies including: modular additive biomanufacturing platforms; advanced bio-inks for regenerative medicine; and additive manufactured tools for surgical planning and education. Highly experienced researchers and industry partners with teams of exceptional post-doctoral fellows and doctoral students would drive each technology. Anticipated impacts are that Australia will be a world-leader in additive biomanufacturing, and that the research will change the fields of science, health and biotechnology.Read moreRead less
A novel approach to the design and fabrication of biomimetic and biocompatible Ti-Ta implants by additive manufacturing. A large number of the Australian population suffer various types of bone issues arising from either age-related degenerative bone problems or injuries from accidents, sports and other activities. As the number of joint replacements performed in Australia increases, it is important to reduce the rate of implant failure. This project aims to address this critical issue by combin ....A novel approach to the design and fabrication of biomimetic and biocompatible Ti-Ta implants by additive manufacturing. A large number of the Australian population suffer various types of bone issues arising from either age-related degenerative bone problems or injuries from accidents, sports and other activities. As the number of joint replacements performed in Australia increases, it is important to reduce the rate of implant failure. This project aims to address this critical issue by combining unique multi-scale structural design, alloy development, 3D printing, modelling and tissue engineering to develop bone-like biomimetic titanium implants with superior structural, mechanical and biological compatibility with bone. The outcomes aim to contribute to both healthcare and manufacturing industries, as well as improving the quality of life for Australians.Read moreRead less
Designing functional biomaterials with superior cellular interactions. This proposal aims to make a new class of biomaterials that direct important cellular functions such as adhesion, proliferation, and differentiation. This will be achieved by developing materials that leverage a previously unexplored mechanism that was recently identified in my lab: the co-engagement of integrin and syndecan-4 cell receptors. We will use these biomaterials to 1) fabricate 3D printed tissue engineering scaffo ....Designing functional biomaterials with superior cellular interactions. This proposal aims to make a new class of biomaterials that direct important cellular functions such as adhesion, proliferation, and differentiation. This will be achieved by developing materials that leverage a previously unexplored mechanism that was recently identified in my lab: the co-engagement of integrin and syndecan-4 cell receptors. We will use these biomaterials to 1) fabricate 3D printed tissue engineering scaffolds with a superior ability to promote the development of new tissue, and 2) create surfaces that will enable us to answer fundamental scientific questions regarding cell adhesion and cell/material interactions.Read moreRead less
Tissue-like, nonlinearly elastic nanobiomaterials for soft tissue regeneration. The purpose of this project is to advance the discipline of soft tissue engineering and regeneration with novel biomaterials, nanotechnology and novel clinical treatment concepts. The key outcomes include new elastic tissue-like nanobiomaterials, new varieties of medical implants and innovative treatment methodology.
Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their inter ....Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their interaction with drugs is essential in order to develop new therapies and to effectively design novel biological compatible bone implants. This research proposal closely aligns with national research priority two, i.e., promoting and maintaining good health (ageing well, ageing productively).Read moreRead less
New generation microfluidic devices using light responsive hydrogels. This project aims to develop a new way of fabricating microfluidic devices using light-degradable hydrogels as its core element. This approach would allow researchers to rapidly construct and modify microfluidic devices within their own laboratories, without the need for specialised clean rooms or expensive equipment. The versatility of the microfluidic device is designed to be demonstrated by the manufacture of mature T cells ....New generation microfluidic devices using light responsive hydrogels. This project aims to develop a new way of fabricating microfluidic devices using light-degradable hydrogels as its core element. This approach would allow researchers to rapidly construct and modify microfluidic devices within their own laboratories, without the need for specialised clean rooms or expensive equipment. The versatility of the microfluidic device is designed to be demonstrated by the manufacture of mature T cells, which continues to be a major challenge in stem cell science and which could have fundamental biological and commercial significance.Read moreRead less
Special Research Initiatives - Grant ID: SR0354583
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Biodevice fabrication through intelligent surface modification. Achieving the reliable control of the attachment of proteins and other macromolecules to surfaces needed for sophisticated biosensors and medical diagnostics requires expertise and infrastructure from a diverse range of disciplines from the physical, chemical and biological sciences and engineering. This network will bring together researchers from a multidisciplinary pool working on problems relevant to the creation of functional s ....Biodevice fabrication through intelligent surface modification. Achieving the reliable control of the attachment of proteins and other macromolecules to surfaces needed for sophisticated biosensors and medical diagnostics requires expertise and infrastructure from a diverse range of disciplines from the physical, chemical and biological sciences and engineering. This network will bring together researchers from a multidisciplinary pool working on problems relevant to the creation of functional surfaces for applications in biodevices. The program we envisage will break down the barriers imposed by disciplinary boundaries and technical terminology to bring together the skills and infrastructure required to make rapid advances in this field.Read moreRead less