Early Career Industry Fellowships - Grant ID: IE230100169
Funder
Australian Research Council
Funding Amount
$457,684.00
Summary
Next-generation mRNA manufacturing and analysis technologies. Developing innovations in RNA manufacturing and technology. The project aims to develop cutting-edge manufacturing and analysis technologies by optimising Self-amplifying (SAM) RNA production towards low impurities, creating reliable purification technologies, and filling critical gaps in RNA analysis. The project expects to yield significantly cheaper, higher-quality RNA products and develop novel methods in RNA analysis. The outcome ....Next-generation mRNA manufacturing and analysis technologies. Developing innovations in RNA manufacturing and technology. The project aims to develop cutting-edge manufacturing and analysis technologies by optimising Self-amplifying (SAM) RNA production towards low impurities, creating reliable purification technologies, and filling critical gaps in RNA analysis. The project expects to yield significantly cheaper, higher-quality RNA products and develop novel methods in RNA analysis. The outcomes are expected to revolutionise RNA manufacturing, develop cutting-edge commercialisable IP, scholarly know-how, and galvanise the Australian biomanufacturing sector towards sovereign capability, biosecurity and commercialisation of new animal, human and plant RNA products.Read moreRead less
A Framework for Software Component Conformance Testing. This research aims to establish a framework - a method, set of tools and business process - within which Commercial-off-the-shelf (COTS) software components can be tested for conformance to client user requirements. There currently exists no general method for validating COTS components without access to source code. We will ?wrap? components in human readable and executable requirements specifications that will be the basis for: client/s ....A Framework for Software Component Conformance Testing. This research aims to establish a framework - a method, set of tools and business process - within which Commercial-off-the-shelf (COTS) software components can be tested for conformance to client user requirements. There currently exists no general method for validating COTS components without access to source code. We will ?wrap? components in human readable and executable requirements specifications that will be the basis for: client/supplier negotiation about component functionality; generating conformance test cases; documentation for integration testing; advertising component capabilities. Outcome: a universally applicable component conformance framework directly beneficial to SMEs, and supporting the development of a robust component marketplace.Read moreRead less
Unravelling how liquids wet surfaces with new dynamic measurements. This project aims to transform our understanding of how liquids wet surfaces in order to provide a step-change in advanced material design. This will be achieved by developing a unifying theory of surface wetting by integrating new microscale models of dynamic wetting with new macroscale automated measurement techniques capable of rapidly generating large datasets, to determine precisely how surface chemistry and surface roughne ....Unravelling how liquids wet surfaces with new dynamic measurements. This project aims to transform our understanding of how liquids wet surfaces in order to provide a step-change in advanced material design. This will be achieved by developing a unifying theory of surface wetting by integrating new microscale models of dynamic wetting with new macroscale automated measurement techniques capable of rapidly generating large datasets, to determine precisely how surface chemistry and surface roughness influence wetting. Expected outcomes include predictive models of surface wetting across multiple scales, and robust high-throughput measurement methods informing optimal design of next-generation materials for all applications where liquids and surfaces interact.Read moreRead less
Next generation material imaging, spectrometry and fabrication techniques. This project aims to solve a common, fundamental problem limiting the performance of mass spectrometers and high resolution electron microscopes: surface modification caused by unintended chemical reactions due to electron impact. The intended project outcomes will advance current understanding of electron restructuring of surfaces and open the door to next-generation material imaging, spectrometry and fabrication techniq ....Next generation material imaging, spectrometry and fabrication techniques. This project aims to solve a common, fundamental problem limiting the performance of mass spectrometers and high resolution electron microscopes: surface modification caused by unintended chemical reactions due to electron impact. The intended project outcomes will advance current understanding of electron restructuring of surfaces and open the door to next-generation material imaging, spectrometry and fabrication techniques. It will develop a superior detector for mass spectrometry and improve the imaging and nanofabrication capabilities of state-of-the-art electron microscopes. Read moreRead less
Creating and Assessing Processes for Object-Oriented and Component-Based Software Development. This project is based on the principles of both theoretical and empirical software engineering. It focuses on the processes, technology and quality of software systems produced using component-based development (CBD) which is achieving substantial software re-use. Among the main objectives of this project are the creation of a unified CBD process metamodel and associated family of reference processes t ....Creating and Assessing Processes for Object-Oriented and Component-Based Software Development. This project is based on the principles of both theoretical and empirical software engineering. It focuses on the processes, technology and quality of software systems produced using component-based development (CBD) which is achieving substantial software re-use. Among the main objectives of this project are the creation of a unified CBD process metamodel and associated family of reference processes together with a closely linked CBD assessment methodology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100010
Funder
Australian Research Council
Funding Amount
$928,291.00
Summary
Single-molecule Manipulation and Interaction Facility (SMIF). This LIEF project aims to establish Australia's first Single-molecule Manipulation and Interaction Facility (SMIF), providing multidisciplinary researchers with a platform to explore cellular processes and reveal molecular mechanisms at the nanoscale. The SMIF facility incorporates cutting-edge technologies for bio-manipulation, real-time visualisation, and characterisation of single-molecule interactions, overcoming the technical com ....Single-molecule Manipulation and Interaction Facility (SMIF). This LIEF project aims to establish Australia's first Single-molecule Manipulation and Interaction Facility (SMIF), providing multidisciplinary researchers with a platform to explore cellular processes and reveal molecular mechanisms at the nanoscale. The SMIF facility incorporates cutting-edge technologies for bio-manipulation, real-time visualisation, and characterisation of single-molecule interactions, overcoming the technical complexity of traditional tools requiring highly specialised personnel. By offering accessible, easy-to-use advanced systems, this project will significantly boost scientific discovery across physics, chemistry, and biology, fostering collaboration and innovation to better understand life at the molecular level.Read moreRead less
Investigations of the Integrity of the Australian Height Datum. The Australian Height Datum (AHD) forms the fundamental framework for all vertical spatial information in Australia. It supports a wide range of applications in areas such as geodesy, surveying, mapping, telecommunications, resource exploration and environmental science. This medium-term research programme will investigate the many issues surrounding the integrity of the AHD, and will rigorously redefine, correct and unify it with ....Investigations of the Integrity of the Australian Height Datum. The Australian Height Datum (AHD) forms the fundamental framework for all vertical spatial information in Australia. It supports a wide range of applications in areas such as geodesy, surveying, mapping, telecommunications, resource exploration and environmental science. This medium-term research programme will investigate the many issues surrounding the integrity of the AHD, and will rigorously redefine, correct and unify it within a global vertical framework. This will provide improved height information to the numerous users of the AHD in Australia, and allow Australia to contribute more fully to the global spatial data infrastructure.Read moreRead less
Theoretical and Model Strengthening of Future Global Navigation Satellite Systems (GNSS) to Yield Improved Geospatial Information for Tomorrow's Society. Australia is a significant user of Global Navigation Satellite Systems (GNSSs) because of its utility and for scientific applications (e.g., Earth-, atmospheric- and space-science). The national benefit of improved integer-estimation and model strengthening of integrated GNSSs is twofold: 1. all future scientific GNSS studies will rest on more ....Theoretical and Model Strengthening of Future Global Navigation Satellite Systems (GNSS) to Yield Improved Geospatial Information for Tomorrow's Society. Australia is a significant user of Global Navigation Satellite Systems (GNSSs) because of its utility and for scientific applications (e.g., Earth-, atmospheric- and space-science). The national benefit of improved integer-estimation and model strengthening of integrated GNSSs is twofold: 1. all future scientific GNSS studies will rest on more reliable positioning and related solutions, and 2. the refinements to these high-precision and high-integrity scientific GNSS applications will feed into much-improved geospatial information for tomorrow's society. Read moreRead less
Problems of identification and inference for 'non-standard' models in complex systems with special reference to finance and teletraffic. The project is concerned with 'non-standard' models needed to deal with complex systems, such as those exhibiting scaling and fractal properties. There is a focus on methods for dealing with heavy tailed distributions and long range dependent observations, for which most standard statistical methods break down, and on applications in finance and telecommunicati ....Problems of identification and inference for 'non-standard' models in complex systems with special reference to finance and teletraffic. The project is concerned with 'non-standard' models needed to deal with complex systems, such as those exhibiting scaling and fractal properties. There is a focus on methods for dealing with heavy tailed distributions and long range dependent observations, for which most standard statistical methods break down, and on applications in finance and telecommunications. An important part of the project concerns model validation for Heyde's fractal activity time geometric Brownian motion model, a candidate minimal description risky asset model to replace the geometric Brownian motion paradigm.Read moreRead less
Synthetic genes as reference standards for biology and biomanufacture. Reference standards are needed to improve the measurement of biology and the reliability of biomanufacturing processes. This project aims to engineer synthetic genes capable of acting as reference standards for DNA, RNA and protein. The synthetic genes can be transcribed into mRNA standards, and translated into protein standards, and be further integrated into living cells to measure internal cellular processes.
The outcomes ....Synthetic genes as reference standards for biology and biomanufacture. Reference standards are needed to improve the measurement of biology and the reliability of biomanufacturing processes. This project aims to engineer synthetic genes capable of acting as reference standards for DNA, RNA and protein. The synthetic genes can be transcribed into mRNA standards, and translated into protein standards, and be further integrated into living cells to measure internal cellular processes.
The outcomes include a unified understanding of gene expression and more accurate next-generation sequencing and mass-spectrophotometry technologies. The synthetic genes also allow standardisation and optimisation of biomanufacturing processes that will produce mRNA and biologics products at a higher purity and lower cost.Read moreRead less