Synthetic genes as reference standards for biology and biomanufacture. Reference standards are needed to improve the measurement of biology and the reliability of biomanufacturing processes. This project aims to engineer synthetic genes capable of acting as reference standards for DNA, RNA and protein. The synthetic genes can be transcribed into mRNA standards, and translated into protein standards, and be further integrated into living cells to measure internal cellular processes.
The outcomes ....Synthetic genes as reference standards for biology and biomanufacture. Reference standards are needed to improve the measurement of biology and the reliability of biomanufacturing processes. This project aims to engineer synthetic genes capable of acting as reference standards for DNA, RNA and protein. The synthetic genes can be transcribed into mRNA standards, and translated into protein standards, and be further integrated into living cells to measure internal cellular processes.
The outcomes include a unified understanding of gene expression and more accurate next-generation sequencing and mass-spectrophotometry technologies. The synthetic genes also allow standardisation and optimisation of biomanufacturing processes that will produce mRNA and biologics products at a higher purity and lower cost.Read moreRead less
A Method for Analysis of Complexity in Cognitive Processes: Applications to Prediction of Industrial Workloads. The project will develop a method for analysis of cognitive complexity in human and animal cognition. It will contribute to basic research because it will enable equivalences and relative complexities of cognitive functions to be determined, independent of content or methodology. It will have applications to education, because it enables complexities of concepts to be recognised and a ....A Method for Analysis of Complexity in Cognitive Processes: Applications to Prediction of Industrial Workloads. The project will develop a method for analysis of cognitive complexity in human and animal cognition. It will contribute to basic research because it will enable equivalences and relative complexities of cognitive functions to be determined, independent of content or methodology. It will have applications to education, because it enables complexities of concepts to be recognised and appropriate pedagogies determined. It also has application to human factors, especially industrial performance and decision making. It will advance on currrent methods because it enables workload to be analysed and predicted, so that it can be factored into job and system design. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100293
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Cracking the phosphoinositide code. This project seeks to determine how protein interactions with membrane lipids regulate recruitment to cellular organelles, providing new insight into the complex pathways of cellular homeostasis. Controlling the distribution of proteins within cells is critical for cell signalling and membrane trafficking. This is orchestrated by the interaction of specific protein modules with lipids on the surface of different organelles. The phox homology (PX) domain is a l ....Cracking the phosphoinositide code. This project seeks to determine how protein interactions with membrane lipids regulate recruitment to cellular organelles, providing new insight into the complex pathways of cellular homeostasis. Controlling the distribution of proteins within cells is critical for cell signalling and membrane trafficking. This is orchestrated by the interaction of specific protein modules with lipids on the surface of different organelles. The phox homology (PX) domain is a lipid-binding module found in numerous proteins essential for normal cell trafficking and homeostasis, and perturbed in many conditions including immune dysfunction and cancer. This project plans to investigate molecular determinants of PX-lipid association, generating knowledge about protein-membrane interactions required for cellular function. These insights may underpin future drug design.Read moreRead less
Preparing Carbon Molecular Sieve Membrane (CMSM) for Olefin/Paraffin Separation. Carbon molecular sieve membrane (CMSM) presents superior selectivity and stability for many gas separation processes. This technology is energy saving, environmental friendly and with minimal operating cost. The project will develop CMSMs for the separation of olefin/paraffin, particularly, the propane/propylene mixture which is currently separated by the energy intensive cryogenic distillation in industry. The pro ....Preparing Carbon Molecular Sieve Membrane (CMSM) for Olefin/Paraffin Separation. Carbon molecular sieve membrane (CMSM) presents superior selectivity and stability for many gas separation processes. This technology is energy saving, environmental friendly and with minimal operating cost. The project will develop CMSMs for the separation of olefin/paraffin, particularly, the propane/propylene mixture which is currently separated by the energy intensive cryogenic distillation in industry. The project involves both experimental works and theoretical studies and will provide: (1) techniques for preparing CMSMs for olefin/paraffin separation; (2) methods characterizing the micro-structure of CMSMs; (3) mathematical models predicting multicomponent gas permeation/separation properties on CMSMs; (4) effect of impurities on the separation processes. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100849
Funder
Australian Research Council
Funding Amount
$364,000.00
Summary
Advanced thermal protection systems to enable Mars return missions. This project aims to advance the modelling of spacecraft heat shield performance to enable future returns to Earth from Mars, where vehicles will encounter heating loads an order of magnitude higher than Lunar returns. Survival depends on sacrificial heat shields which intentionally lose mass through ablation to form a protective layer. Currently, this process cannot be predicted accurately leading to compromised safety, excessi ....Advanced thermal protection systems to enable Mars return missions. This project aims to advance the modelling of spacecraft heat shield performance to enable future returns to Earth from Mars, where vehicles will encounter heating loads an order of magnitude higher than Lunar returns. Survival depends on sacrificial heat shields which intentionally lose mass through ablation to form a protective layer. Currently, this process cannot be predicted accurately leading to compromised safety, excessive weight, and increased mission cost. The expected outcome is an ablation model for vehicle design which, for the first time, is based on experiments with a realistic aerodynamic flow. The significance and benefit of this project is its potential to make ambitious missions such as a Mars return feasible.Read moreRead less