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The Negative Transgenerational Impacts Of Paternal Obesity Are Inherited Through Aberrant Methylation And MicroRNA Conetent Of Germ Cells.
Funder
National Health and Medical Research Council
Funding Amount
$307,946.00
Summary
We have shown that obese fathers have reduced sperm function that negatively impacts upon their offspring’s health. But we do not understand the underlying alterations to sperm DNA that cause offspring to inherit poor health from an obese father, and whether these offspring also exhibit the same alterations. My project aims to identify alterations made to sperm DNA and RNA caused by obesity that are inherited by the next generation, ‘programming’ them for poor metabolic and reproductive health.
Production Of Humanised Mouse Models For Haemoglobin E And 0-thalassaemia
Funder
National Health and Medical Research Council
Funding Amount
$280,693.00
Summary
The proposed study aims to identify and characterise genes critical to male fertility using two mouse models of infertility: 1) Joey mouse line: an ENU induced model of sperm abnormalities. Following linkage analysis, candidate genes will be selected for sequencing to identify the causal mutation. 2) Ggn knockout mice. The role of the testis-specific gene, Ggn will be characterised through a phenotypic analysis of Ggn knockout mice and a series of expression and biochemical analyses. Both models ....The proposed study aims to identify and characterise genes critical to male fertility using two mouse models of infertility: 1) Joey mouse line: an ENU induced model of sperm abnormalities. Following linkage analysis, candidate genes will be selected for sequencing to identify the causal mutation. 2) Ggn knockout mice. The role of the testis-specific gene, Ggn will be characterised through a phenotypic analysis of Ggn knockout mice and a series of expression and biochemical analyses. Both models will be of direct value in the identification of commercially relevant contraceptive targets, as well as furthering our understanding of male reproductive function.Read moreRead less
Prevalence Of Genital HPV Infection In Males Following Introduction Of Universal Male HPV Vaccination
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
As Australia is the first and only country to implement a free universal school based male human papillomavirus (HPV) vaccination program (in 2013), this project has the unique opportunity to be first to study to assess the effectiveness of the male HPV vaccination program in Australia by measuring a change in the prevalence of HPV among young (aged 17-20) heterosexual and homosexual men following the implementation of the vaccination program.
‘The Hearts And Minds Study’: A Population Study Of Mental Health Trajectories, Cardiovascular Outcomes And Shared Biological Markers In Childhood And Mid-adulthood
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Cardiovascular disease and mental illness are leading causes of mortality and morbidity. They frequently co-occur in adulthood, but it is poorly understand how and when this relationship develops. The Hearts and Minds Study will examine how mental health (positive and negative) over a 10-year period impacts cardiovascular health at two important life course stages: early childhood and mid-adulthood. Findings will enhance understanding of cardiovascular and mental health in our community.
Establishing Innovative Methods In Psychiatric Epidemiology And Services Research: Achieving Better Outcomes In Vulnerable Populations
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This Fellowship aims to reduce the burden associated with mental disorders in vulnerable populations. This body of work will provide a comprehensive assessment of the predictors, prevention and treatment of mental disorders in these populations, so as to inform resource allocation and service delivery. It will also assess more effective ways to implement services.
Towards Evidence-based Adoption And Scale-up Of Cost-saving Primary Health Care Innovations
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
What innovations like service integration, care coordination and information technology (e.g. text message reminders, remote video consultations, remote monitoring) have in common is that they alter the patient-provider interface, more reliably and consistently than improving clinical outcomes. So, to determine their true costs and benefits, how to select among them and how to scale them up, this research program will assess them based on measures of how they alter patient-provider transactions.
Researching Effective Strategies To Tackle Tobacco Use In Indigenous Populations In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$353,438.00
Summary
Twice as many Indigenous Australians smoke as non-Indigenous. Smoking is a major cause of poor health amongst Indigenous adults and exposure of Indigenous children to second hand smoke is associated with childhood respiratory illness. The aim of this project is to find out which tobacco control programs work best to both reduce rates of smoking amongst Indigenous people and protect children from harmful second hand smoke.
Towards Improved Maternal And Childhood Vaccine Uptake: Managing The Challenge And Opportunity Of Complementary Medicine Practitioners
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Certain geographical areas with lower rates of vaccination pose considerable concern. Complementary medicine practitioners are often visited by vaccine-hesitant parents and are influential in their decisions about vaccination. This research provides the first examination of complementary medicine practitioner beliefs and practices regarding vaccination. Resources will be developed to help manage conversations between complementary medicine practitioners and vaccine-hesitant parents.