Validating Novel Biomarkers Relevant To Major Depression
Funder
National Health and Medical Research Council
Funding Amount
$515,550.00
Summary
Depression prevention and treatment are public health priorities; therefore, it is critical to improve and personalise treatments, which can only be achieved by advancing knowledge of its underlying biology. This research project will contribute to validating potentially relevant genes for MDD risk or antidepressant response and to provide the scientific foundation for future strategies to test their products as MDD biomarkers in the clinical setting.
AusGDB-Depression: An Australian Genetic Database Study Of Functional Genetic Variants And Environmental Factors In Major Depression
Funder
National Health and Medical Research Council
Funding Amount
$620,486.00
Summary
Major depression is the leading cause of disability in Australia, but its causes are unknown. Despite a significant role of genes in this disorder and many genetic studies, researchers have not been able to identify the genes that increase the risk for this disorder. In this project, we will identify, characterize and use genetic functional variants and environmental factors to create a way to predict diagnosis of this disorder.
Developing Evidence For The Primary Prevention Of Depressive Disorders: The Role Of Diet And Physical Activity
Funder
National Health and Medical Research Council
Funding Amount
$672,136.00
Summary
This study will examine the association between diet, physical activity and depression and bipolar disorders. It will examine whether an individual's regular diet and-or levels of physical activity are related to the development and-or course of these psychiatric illnesses. There is evidence to suggest that our changing diets may play an important role in the development of mood disorders such as depression. The typical western diet has become high in saturated fats and refined sugar, while the ....This study will examine the association between diet, physical activity and depression and bipolar disorders. It will examine whether an individual's regular diet and-or levels of physical activity are related to the development and-or course of these psychiatric illnesses. There is evidence to suggest that our changing diets may play an important role in the development of mood disorders such as depression. The typical western diet has become high in saturated fats and refined sugar, while the consumption of fresh fruits and vegetables has declined, and these large-scale dietary changes may be contributing to increasing rates of depression. Moreover, there is evidence of physical activity being protective against depression, while physical inactivity is a risk factor for depression. Our lifestyles are increasingly sedentary and this may also be a contributing factor to the development of mood disorders. This study will involve women enrolled in the Geelong Osteoporosis Study (GOS), which comprises a highly representative sample of randomly-selected women from the Barwon region. The study will prospectively examine the relationships between diet and exercise and the later development of depressive disorders. To date, there is little data focusing on the role of lifestyle factors in the development of depressive disorders. This study will contribute comprehensive information regarding modifiable lifestyle factors that play a role in the development of these disorders. This data can be incorporated with information regarding other modifiable risk factors, such as drug and alcohol misuse, to create a simple public health message on how to reduce one's risk of developing these disorders. A preventative approach to mental illness would be cost-effective and able to be implemented at a population level. It is likely to lead to better outcomes for those affected by depressive illnesses and reduce the public health burden of psychiatric illness in Australia.Read moreRead less
Neural Predictors Of Treatment Response In Youth Depression
Funder
National Health and Medical Research Council
Funding Amount
$519,596.00
Summary
Depression is the single greatest cause of disability and morbidity in young people. In order to reduce its substantial burden on individuals and society, there is a need to optimise the early provision of existing treatments. In this study, we will use cutting-edge neuroimaging technology to identify “biomarkers” in the brain that will help to more accurately determine which available treatments are likely to be most effective and safe for an individual patient.
Long-term Metabolic Effects Of Stress And Antidepressants: A Novel Translational Animal Paradigm Of Drug-induced Obesity
Funder
National Health and Medical Research Council
Funding Amount
$518,231.00
Summary
Do antidepressants contribute to Australia's obesity epidemic? Millions of Australians are treated with antidepressants, which often causes weight gain. Our work shows that even brief exposure to antidepressants exacerbate body weight gain following exposure to chronic stress. This new knowledge represents a significant shift in the understanding of antidepressant-related weight gain. In this project we will study the mechanisms involved in long-term weight gain after exposure to stress and anti ....Do antidepressants contribute to Australia's obesity epidemic? Millions of Australians are treated with antidepressants, which often causes weight gain. Our work shows that even brief exposure to antidepressants exacerbate body weight gain following exposure to chronic stress. This new knowledge represents a significant shift in the understanding of antidepressant-related weight gain. In this project we will study the mechanisms involved in long-term weight gain after exposure to stress and antidepressants in an obesogenic environment.Read moreRead less
Postpartum Depression: Action Towards Causes And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$570,699.00
Summary
We will recruit women into a large international study to identify genetic variants that increase risk of perinatal depression using a mobile app. Women who screen positive will be asked to provide a spit sample for DNA.
Deep Brain Stimulation In The Treatment Of Severe Depression
Funder
National Health and Medical Research Council
Funding Amount
$1,008,087.00
Summary
Some patients with depression fail to respond to a variety of standard treatments and in this group, deep brain stimulation (DBS) is being evaluated as an alternative treatment option. This study will investigate the use of DBS applied to a novel brain target site in patients with highly treatment refractory depression.
Providing Evidence For The Primary Prevention Of The High-prevalence Mental Disorders In Men: The Role Of Diet In The Aetiology Of Depression, Anxiety, And Psychological Distress
Funder
National Health and Medical Research Council
Funding Amount
$300,862.00
Summary
Depression is predicted to become the second-most common cause of disability in the world by 2020, despite the increased energy devoted to recognition and treatment. This study will examine the association between diet quality and depressive and anxiety disorders in men, to identify to what extent diet quality is related to the risk for and/or course of these illnesses.
Diet As A Therapeutic Target In Depression: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$498,564.00
Summary
Depression is predicted to become the second-most common cause of disability in the world by 2020. While there is now compelling new evidence to suggest that diet plays an important role in the risk for and the genesis of depression, there are no existing data regarding the impact of dietary improvement on existing depressive illness. The aim of the proposed study is to answer the critically important and frequently asked question "If I improve my diet, will my mental health improve?"
Differential Changes In Cortical Tumour Necrosis Factor Signalling In Mood Disorders And Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$642,078.00
Summary
Changes in inflammation-related pathways contribute to the symptoms of psychiatric disorders and tumour necrosis factor ? (TNF) is a protein central to regulating theses pathways. We have now shown that changes in pathways regulated by TNF are present in the brains of people with schizophrenia and mood disorders. This means that the symptoms experienced by those with the different disorders may be linked to differential changes in TNF-regulated pathways in the brain.