The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
Predictors Of Response To Antidepressants: Utility Of Behavioural, Neuroimaging And Genetics Data
Funder
National Health and Medical Research Council
Funding Amount
$310,071.00
Summary
Major depressive disorder (MDD) is projected to cause the second greatest global burden of disease by 2020, highlighting the urgent need for valid predictors of effective treatment response. Currently, there are no accurate predictors of response to antidepressants in MDD, and successful treatment relies greatly on 'trial and error'. This process is demanding on health resources, and may be a factor in the high suicide rates in depressed patients. Previous research on treatment response has been ....Major depressive disorder (MDD) is projected to cause the second greatest global burden of disease by 2020, highlighting the urgent need for valid predictors of effective treatment response. Currently, there are no accurate predictors of response to antidepressants in MDD, and successful treatment relies greatly on 'trial and error'. This process is demanding on health resources, and may be a factor in the high suicide rates in depressed patients. Previous research on treatment response has been limited by recruitment of small, heterogeneous patient samples, lack of placebo control, and a failure to examine task related activity in brain imaging studies. Perhaps one of the more troubling aspects of research that aims to predict treatment response to antidepressant medications is the use of commonly used outcome measures such as the Hamilton Rating Depression Scale (HAM-D), which were developed long before current classification systems of depression came into use. The US Federal Drug Administration has recently identified what they call a translational gap such that behavioural and biological measures are the most robust for detection of disorders such as depression, yet these measures remain to be translated into clinical tools that can be used to evaluate treatment. The aim of the current study therefore is to determine whether genetic variability is related to treatment outcome as defined by a more objective outcome measure (facial expression perception) using a randomised controlled design. The study will also determine whether brain measures (fMRI, EEG) enhance the prediction of SSRI response to both clinical and behavioural measures, over and above the genetic contribution.Read moreRead less
STudy Of Risk Assessment To Reduce Complications In Patients Following Noncardiac SurgerY (STRATIFY)
Funder
National Health and Medical Research Council
Funding Amount
$436,000.00
Summary
Cardiac problems account for many complications in patients undergoing major non-cardiac surgery, and even apparently minor cardiac damage is a marker of high risk for subsequent adverse events. Unfortunately, while money and effort is expended on identifying patients at risk, the appropriate response to this risk is quite unclear. The performance of bypass surgery or balloon angioplasty in order to treat the underlying coronary disease of at-risk patients is used in other situations, and reduce ....Cardiac problems account for many complications in patients undergoing major non-cardiac surgery, and even apparently minor cardiac damage is a marker of high risk for subsequent adverse events. Unfortunately, while money and effort is expended on identifying patients at risk, the appropriate response to this risk is quite unclear. The performance of bypass surgery or balloon angioplasty in order to treat the underlying coronary disease of at-risk patients is used in other situations, and reduces longterm risk. However, in many patients undergoing major noncardiac surgery, this approach may be inappropriately aggressive, as these patients are often elderly, have other diseases that make heart operations more difficult and risky than usual, and in any case may have a reduced life expectancy from the disease necessitating the operation. As the most critical issue is to ensure that patients undergo their surgery uneventfully, an alternative is the use of intensive medical therapy to protect the heart. This multicentre study, based at Brisbane hospitals that perform large numbers of major operations, will follow up patients for complications, and outcome (including quality of life) will be assessed six months after the operation. We will address two important questions about the efficacy and cost of risk reduction strategies. First, in patients at higher levels of risk and with a positive stress test, could a combination of medical therapy designed to protect the heart be as effective as current approaches, which include the performance of bypass surgery or coronary balloon angioplasty? Second, in patients identified as being at some risk - but low risk - are drugs sufficiently effective to avoid the need for further testing to quantify risk? As the population continues to age, the numbers of at risk patients undergoing major surgery will increase, and answers to these questions will provide important information to guide their management.Read moreRead less
The time of our lives: Time equity and the balancing of market and non-market production in the modern Australian population. This project will yield new information relevant to the national social inclusion agenda and the research priority goal of understanding and strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, fulfilling lives. Through a multilayered analysis of gender, class, life course stage, time allocation and the connection ....The time of our lives: Time equity and the balancing of market and non-market production in the modern Australian population. This project will yield new information relevant to the national social inclusion agenda and the research priority goal of understanding and strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, fulfilling lives. Through a multilayered analysis of gender, class, life course stage, time allocation and the connections between them, it will demonstrate links between various forms of social and economic participation and identify how they could be distributed more evenly. This knowledge is important to inform policy to better enable young people to become independent, families to both earn a living and care well for their children, and older people to be productive and socially engaged.Read moreRead less
Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income familie ....Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income families. The direct involvement of child care providers in the research will strengthen its relevance and impact. This research will place Australia at the forefront of international research on local child care markets, and resulting improvements in ECEC policy and services will generate substantial economic and social benefits.Read moreRead less
Social transformation and international migration in the 21st century. Understanding the factors that shape international migration is crucial for Australia, because planned immigration remains a cornerstone of policy, yet traditional assumptions on the predominance of permanent settlement and the geographical controllability of movement are losing their validity. This project will help create the social scientific tools for new approaches to understanding migration and diversity at the global, ....Social transformation and international migration in the 21st century. Understanding the factors that shape international migration is crucial for Australia, because planned immigration remains a cornerstone of policy, yet traditional assumptions on the predominance of permanent settlement and the geographical controllability of movement are losing their validity. This project will help create the social scientific tools for new approaches to understanding migration and diversity at the global, regional and national levels. It will help Australian governments and civil society address new challenges in this field. It will also contribute to developing a highly-trained workforce for fundamental research on migration and social transformation. Read moreRead less
The canonical stratification of jet spaces. Singularities occur everywhere in nature, from the formation and collapse of stars to the morphology of living embryos. They appear whenever the geometry of surfaces or spaces undergoes a process of twisting, folding, or collapsing on itself. Singularity Theory is the study of such phenomena, an important branch of modern mathematics which has close connections with many other branches of mathematics and applied sciences. Singularity Theory lies at the ....The canonical stratification of jet spaces. Singularities occur everywhere in nature, from the formation and collapse of stars to the morphology of living embryos. They appear whenever the geometry of surfaces or spaces undergoes a process of twisting, folding, or collapsing on itself. Singularity Theory is the study of such phenomena, an important branch of modern mathematics which has close connections with many other branches of mathematics and applied sciences. Singularity Theory lies at the crossroads of the paths connecting the most important areas of applications of mathematics with its most abstract parts. Analytic Singularity Theory is a central part of Singularity Theory. This project would lead to substantially new advancements in Analytic Singularity Theory.Read moreRead less
The Politics of Moral Order: How Peripheralised Communities are Made and Masked. The focus of this research is two peripheralised communities, one in Central Australia, and the other Kingston, Jamaica. It will analyse their anomalous economies, the welfare economy in Central Australia and the drug economy in downtown Kingston, in order to demonstrate how cultural difference and disprivilege are masked by a politics of moral order. The project will therefore explore a central feature of modernity ....The Politics of Moral Order: How Peripheralised Communities are Made and Masked. The focus of this research is two peripheralised communities, one in Central Australia, and the other Kingston, Jamaica. It will analyse their anomalous economies, the welfare economy in Central Australia and the drug economy in downtown Kingston, in order to demonstrate how cultural difference and disprivilege are masked by a politics of moral order. The project will therefore explore a central feature of modernity and demonstrate striking structural parallels, both mythic and social, at sites with different histories and cultures.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100468
Funder
Australian Research Council
Funding Amount
$365,144.00
Summary
Decentralisation in India and Indonesia: how non-government organisations affect citizens' encounters and experiences of local level governance. This project critically examines how local non-government organisations affect decentralisation in India and Indonesia. It offers new understandings of the potential for development agencies to transform the meanings, practices and identities that shape how citizens experience local governance.