Role Of SPPL2A On B Cell Survival And Antibody Production In Mice And Humans
Funder
National Health and Medical Research Council
Funding Amount
$592,989.00
Summary
B lymphocytes are a specialised type of blood cells that produce antibodies in response to a pathogen or a vaccine. We have recently discovered that all mature B cells depend for their survival on a previously unknown protein called SPPL2A. This application will investigate the molecular mechanism through which SPPL2A contributes to the survival of B cells. We will also investigate if humans with currently unexplained B cell deficiency have mutations in SPPL2A.
Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income familie ....Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income families. The direct involvement of child care providers in the research will strengthen its relevance and impact. This research will place Australia at the forefront of international research on local child care markets, and resulting improvements in ECEC policy and services will generate substantial economic and social benefits.Read moreRead less
Inequality in first family formation in contemporary Australia. The timing and context of Australians' entry into parenthood differs across the socio-economic spectrum. This project investigates the socio-economic disparities in entering parenthood, particularly focusing on education and employment differentials as well as socio-demographic factors such as ethnic and religious background, and experience of family dissolution. Using longitudinal panel data, this project aims to: determine the soc ....Inequality in first family formation in contemporary Australia. The timing and context of Australians' entry into parenthood differs across the socio-economic spectrum. This project investigates the socio-economic disparities in entering parenthood, particularly focusing on education and employment differentials as well as socio-demographic factors such as ethnic and religious background, and experience of family dissolution. Using longitudinal panel data, this project aims to: determine the socio-economic and demographic differentials of inequality in first family formation in Australia; discover how inequality in first family formation has changed since the middle of the 20th Century; and, assess how family-policy regime mediates or exacerbates this inequality.Read moreRead less
Special Research Initiatives - Grant ID: SR0354580
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible ....Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible responses to the challenge of creating sustainable societies in a changing world. Through a greater understanding of past societies' reactions to rapid environmental change, the Network will build on existing leading edge research and create a more informed guide to a sustainable future.Read moreRead less
Tracking 3000 years of agricultural adaptation to the resource poor, climate sensitive and remote Solomon Islands using biomarkers and palaeoecology. Establishing research programs with Pacific neighbours benefits Australia's relations with Pacific Island countries generally. This project applies novel research methods to understanding human adaptations to long-term environmental and climatic fluctuations. It will address the National Research Priority goal of responding to climate variability b ....Tracking 3000 years of agricultural adaptation to the resource poor, climate sensitive and remote Solomon Islands using biomarkers and palaeoecology. Establishing research programs with Pacific neighbours benefits Australia's relations with Pacific Island countries generally. This project applies novel research methods to understanding human adaptations to long-term environmental and climatic fluctuations. It will address the National Research Priority goal of responding to climate variability by advancing our understanding of recent climate change in the Australia/Pacific region. It will show that Australian researchers can play a significant role in understanding the spread of humans across the Pacific, and the environmental adaptations required by populations in resource depleted environments. It will increase collaboration between research institutions focusing on the Australia/Pacific region.Read moreRead less
Using fossil insects and plants to recognise past human impacts on Pacific island biodiversity. This project will enhance our ability to characterise human impact on island biodiversity. It will develop novel research methods that can be applied in the Australian context to understand changes in biodiversity that come with human impact. The contemporary emphasis on biosecurity in the protection of Australia's unique environment against human-introduced exotic pests and diseases can be better und ....Using fossil insects and plants to recognise past human impacts on Pacific island biodiversity. This project will enhance our ability to characterise human impact on island biodiversity. It will develop novel research methods that can be applied in the Australian context to understand changes in biodiversity that come with human impact. The contemporary emphasis on biosecurity in the protection of Australia's unique environment against human-introduced exotic pests and diseases can be better understood in the context of past introductions. Our project will demonstrate the role Australian archaeologists and natural scientists can play in understanding the spread of humans across the Pacific and the environmental consequences of colonisation. It will increase collaboration between research institutions in the Australia/Pacific region.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Revisiting the 'Fourth Age': health, socioeconomic and cultural transformation of, and diversity in, Australia's oldest old population, 1981-2011. The oldest-old (those aged 85 years and over) is the fastest growing segment of the Australian population, and the changing make-up and experiences of this group needs attention. This project will expand our knowledge base about Australia's oldest old, helping to inform public policy and to improve discussions on what the 'Fourth Age' really means in ....Revisiting the 'Fourth Age': health, socioeconomic and cultural transformation of, and diversity in, Australia's oldest old population, 1981-2011. The oldest-old (those aged 85 years and over) is the fastest growing segment of the Australian population, and the changing make-up and experiences of this group needs attention. This project will expand our knowledge base about Australia's oldest old, helping to inform public policy and to improve discussions on what the 'Fourth Age' really means in Australia.Read moreRead less
Welfare reform and welfare stigma : scroungers, slackers and bludgers? This project aims to build an evidence base of the prevalence, causes and consequences of welfare stigma in Australia. Welfare policies and proposed reforms aim to reduce welfare expenditure, increase workforce participation, and promote personal and family wellbeing. However, stigmatising attitudes and discrimination towards those receiving welfare benefits may undermine these policy goals: reducing employment opportunities ....Welfare reform and welfare stigma : scroungers, slackers and bludgers? This project aims to build an evidence base of the prevalence, causes and consequences of welfare stigma in Australia. Welfare policies and proposed reforms aim to reduce welfare expenditure, increase workforce participation, and promote personal and family wellbeing. However, stigmatising attitudes and discrimination towards those receiving welfare benefits may undermine these policy goals: reducing employment opportunities and causing poorer health and wellbeing. Through innovative experimental studies, the project plans to identify ways in which welfare policy can minimise stigma and promote employment. Project outcomes may provide an evidence base for the design of more effective welfare policy.Read moreRead less
Meeting the needs of older persons in Indonesia. The project aims to identify the needs of older people in rural Indonesia for income, housing, health, daily care and social interaction and the extent to which their needs are met. It also considers the efficacy of existing policy programs and how these might be improved. Today, there are 22 million Indonesians aged 60 years and over, projected to rise to 48 million by 2035. Millions of older people live in rural areas from which younger people h ....Meeting the needs of older persons in Indonesia. The project aims to identify the needs of older people in rural Indonesia for income, housing, health, daily care and social interaction and the extent to which their needs are met. It also considers the efficacy of existing policy programs and how these might be improved. Today, there are 22 million Indonesians aged 60 years and over, projected to rise to 48 million by 2035. Millions of older people live in rural areas from which younger people have moved to the rapidly growing cities. This presents challenges for the traditional family-based aged care system in Indonesia. It is expected that findings from the study will be published in a series of policy papers to be presented in the Indonesian National Development Planning Board.Read moreRead less