Macrophages are white blood cells that provide front line defence against infection by initiating inflammatory responses by ingesting or phagocytosing microbes and by releasing soluble messengers (cytokines) to recruit other immune cells. These defensive functions require extensive trafficking of proteins within the macrophages. Protein trafficking is orchestrated in part by a family of membrane fusion proteins called SNAREs. By defining the relevant SNAREs, we have recently discovered a much ac ....Macrophages are white blood cells that provide front line defence against infection by initiating inflammatory responses by ingesting or phagocytosing microbes and by releasing soluble messengers (cytokines) to recruit other immune cells. These defensive functions require extensive trafficking of proteins within the macrophages. Protein trafficking is orchestrated in part by a family of membrane fusion proteins called SNAREs. By defining the relevant SNAREs, we have recently discovered a much acclaimed and novel pathway that allows efficient, combined cytokine secretion and phagocytosis in macrophages. Our studies proposed here will now expand on this discovery by comparing the phagocytic process, in terms of SNARE-mediated membrane and cytokine trafficking, for a wide range of microbes, highlighting differences that could provide new avenues for drug development. Moreover, since our strategy of using SNAREs to investigate and map trafficking pathways has proven so successful, we will now launch a major large-scale initiative to study ALL SNARE-mediated trafficking pathways in macrophages using a discovery pipeline of assays, including live cell imaging, we have developed. This will provide valuable information on many SNAREs including those associated with disease, and will elucidate trafficking pathways governing all macrophage actions in immunity, including cytokine secretion and antigen presentation. All of these pathways are highly relevant to current drug targets being used clinically or studied in inflammatory disease and for the development of vaccines.Read moreRead less
STudy Of Risk Assessment To Reduce Complications In Patients Following Noncardiac SurgerY (STRATIFY)
Funder
National Health and Medical Research Council
Funding Amount
$436,000.00
Summary
Cardiac problems account for many complications in patients undergoing major non-cardiac surgery, and even apparently minor cardiac damage is a marker of high risk for subsequent adverse events. Unfortunately, while money and effort is expended on identifying patients at risk, the appropriate response to this risk is quite unclear. The performance of bypass surgery or balloon angioplasty in order to treat the underlying coronary disease of at-risk patients is used in other situations, and reduce ....Cardiac problems account for many complications in patients undergoing major non-cardiac surgery, and even apparently minor cardiac damage is a marker of high risk for subsequent adverse events. Unfortunately, while money and effort is expended on identifying patients at risk, the appropriate response to this risk is quite unclear. The performance of bypass surgery or balloon angioplasty in order to treat the underlying coronary disease of at-risk patients is used in other situations, and reduces longterm risk. However, in many patients undergoing major noncardiac surgery, this approach may be inappropriately aggressive, as these patients are often elderly, have other diseases that make heart operations more difficult and risky than usual, and in any case may have a reduced life expectancy from the disease necessitating the operation. As the most critical issue is to ensure that patients undergo their surgery uneventfully, an alternative is the use of intensive medical therapy to protect the heart. This multicentre study, based at Brisbane hospitals that perform large numbers of major operations, will follow up patients for complications, and outcome (including quality of life) will be assessed six months after the operation. We will address two important questions about the efficacy and cost of risk reduction strategies. First, in patients at higher levels of risk and with a positive stress test, could a combination of medical therapy designed to protect the heart be as effective as current approaches, which include the performance of bypass surgery or coronary balloon angioplasty? Second, in patients identified as being at some risk - but low risk - are drugs sufficiently effective to avoid the need for further testing to quantify risk? As the population continues to age, the numbers of at risk patients undergoing major surgery will increase, and answers to these questions will provide important information to guide their management.Read moreRead less
Protect from harm or lead into danger? The influence of peers in leisure activities on adolescent behaviour. When are peers a bad influence? This project will offer answers about the leisure settings that expose young people to risk and those that protect them from harm during the high school years. This research will also help identify those youth who may be especially vulnerable to negative effects of peer influence.
Regulating The Secretion Of Inflammatory Cytokines
Funder
National Health and Medical Research Council
Funding Amount
$558,441.00
Summary
Cytokines or chemical messengers released by cells are essential for controlling immune responses but, in excess, they cause Crohn's disease and arthritis. Our research aims to block cytokine release as a novel way to ameliorate disease. We have identified specific cellular proteins, called golgins, that can be targeted to reduce cytokines. Here, characterization of golgin mediated cytokine transport in cells and in a mouse disease model is necessary to translate these findings for human benefit
Discovery Early Career Researcher Award - Grant ID: DE120101206
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Offending across the life-course: testing developmental and life-course theories of crime. There are many different explanations for why people start and stop offending. This project will draw on a range of Australian and international data to determine which explanations provide the most accurate description of why people engage in offending and the processes which lead offenders to stop offending.
Addressing food insecurity through participatory social enterprise. This project aims to address food insecurity by assisting vulnerable populations to participate in the development of new food businesses. The project is expected to empower individuals and communities and create new economic development opportunities. The social and economic benefits of this project includes increased access to food, greater participation in new food enterprises and an improved quality of life for vulnerable pe ....Addressing food insecurity through participatory social enterprise. This project aims to address food insecurity by assisting vulnerable populations to participate in the development of new food businesses. The project is expected to empower individuals and communities and create new economic development opportunities. The social and economic benefits of this project includes increased access to food, greater participation in new food enterprises and an improved quality of life for vulnerable people experiencing food insecurity in Australia.Read moreRead less
Community variations in crime: A spatial and ecometric analysis. Collective Efficacy (CE) is a new theoretical construct (that has never been investigated in Australia). It is a task-specific process for mobilising social capital to tackle specific neighbourhood problems. Research in Chicago finds that communities with high levels of CE experience lower levels of violence regardless of poverty levels. We will conduct a spatial and ecometric analysis of CE and crime using a survey of 3000 residen ....Community variations in crime: A spatial and ecometric analysis. Collective Efficacy (CE) is a new theoretical construct (that has never been investigated in Australia). It is a task-specific process for mobilising social capital to tackle specific neighbourhood problems. Research in Chicago finds that communities with high levels of CE experience lower levels of violence regardless of poverty levels. We will conduct a spatial and ecometric analysis of CE and crime using a survey of 3000 residents in 50 Brisbane communities. We will compare similar data from Chicago and Stockholm to investigate the Australian contribution of CE to spatial crime patterns and its potential for future crime prevention programs.Read moreRead less
The high cost of financial insecurity: exploring the role of the 'fringe economy' in the lives of low-income Australians. The national benefit from this research has a number of dimensions. The first is to draw the community's attention to the high costs and charges associated with fringe lenders in Australia and the economic and social consequences of accessing these services. The second benefit relates to establishing what sorts of financial products and regulatory measures would offer low-inc ....The high cost of financial insecurity: exploring the role of the 'fringe economy' in the lives of low-income Australians. The national benefit from this research has a number of dimensions. The first is to draw the community's attention to the high costs and charges associated with fringe lenders in Australia and the economic and social consequences of accessing these services. The second benefit relates to establishing what sorts of financial products and regulatory measures would offer low-income Australians a better outcome. A number of states in Australia have recently introduced legislation to limit the interest rates charged by pay-day lenders. The study is very timely in that it offers an opportunity to monitor the impact of these new regulatory measures and consider opportunities for further reform.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.