The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
Predictors Of Response To Antidepressants: Utility Of Behavioural, Neuroimaging And Genetics Data
Funder
National Health and Medical Research Council
Funding Amount
$310,071.00
Summary
Major depressive disorder (MDD) is projected to cause the second greatest global burden of disease by 2020, highlighting the urgent need for valid predictors of effective treatment response. Currently, there are no accurate predictors of response to antidepressants in MDD, and successful treatment relies greatly on 'trial and error'. This process is demanding on health resources, and may be a factor in the high suicide rates in depressed patients. Previous research on treatment response has been ....Major depressive disorder (MDD) is projected to cause the second greatest global burden of disease by 2020, highlighting the urgent need for valid predictors of effective treatment response. Currently, there are no accurate predictors of response to antidepressants in MDD, and successful treatment relies greatly on 'trial and error'. This process is demanding on health resources, and may be a factor in the high suicide rates in depressed patients. Previous research on treatment response has been limited by recruitment of small, heterogeneous patient samples, lack of placebo control, and a failure to examine task related activity in brain imaging studies. Perhaps one of the more troubling aspects of research that aims to predict treatment response to antidepressant medications is the use of commonly used outcome measures such as the Hamilton Rating Depression Scale (HAM-D), which were developed long before current classification systems of depression came into use. The US Federal Drug Administration has recently identified what they call a translational gap such that behavioural and biological measures are the most robust for detection of disorders such as depression, yet these measures remain to be translated into clinical tools that can be used to evaluate treatment. The aim of the current study therefore is to determine whether genetic variability is related to treatment outcome as defined by a more objective outcome measure (facial expression perception) using a randomised controlled design. The study will also determine whether brain measures (fMRI, EEG) enhance the prediction of SSRI response to both clinical and behavioural measures, over and above the genetic contribution.Read moreRead less
Global production networks and worker representation in Myanmar. This project aims to assess the impact of global production networks on worker representation in Myanmar’s garment sector, which is leading the country’s integration into global supply chains at this crucial time in its economic and political development. This project’s findings will be used to theorise how complex interactions between different economic and social actors across geographic scale affect the rights and interests of g ....Global production networks and worker representation in Myanmar. This project aims to assess the impact of global production networks on worker representation in Myanmar’s garment sector, which is leading the country’s integration into global supply chains at this crucial time in its economic and political development. This project’s findings will be used to theorise how complex interactions between different economic and social actors across geographic scale affect the rights and interests of garment workers, and the quality of their employment. This will provide significant benefits that will make an important contribution to scholarly understandings of the impact of labour agency on global production networks and provide a strong evidence base for decision-making by local and international stakeholders.Read moreRead less
STudy Of Risk Assessment To Reduce Complications In Patients Following Noncardiac SurgerY (STRATIFY)
Funder
National Health and Medical Research Council
Funding Amount
$436,000.00
Summary
Cardiac problems account for many complications in patients undergoing major non-cardiac surgery, and even apparently minor cardiac damage is a marker of high risk for subsequent adverse events. Unfortunately, while money and effort is expended on identifying patients at risk, the appropriate response to this risk is quite unclear. The performance of bypass surgery or balloon angioplasty in order to treat the underlying coronary disease of at-risk patients is used in other situations, and reduce ....Cardiac problems account for many complications in patients undergoing major non-cardiac surgery, and even apparently minor cardiac damage is a marker of high risk for subsequent adverse events. Unfortunately, while money and effort is expended on identifying patients at risk, the appropriate response to this risk is quite unclear. The performance of bypass surgery or balloon angioplasty in order to treat the underlying coronary disease of at-risk patients is used in other situations, and reduces longterm risk. However, in many patients undergoing major noncardiac surgery, this approach may be inappropriately aggressive, as these patients are often elderly, have other diseases that make heart operations more difficult and risky than usual, and in any case may have a reduced life expectancy from the disease necessitating the operation. As the most critical issue is to ensure that patients undergo their surgery uneventfully, an alternative is the use of intensive medical therapy to protect the heart. This multicentre study, based at Brisbane hospitals that perform large numbers of major operations, will follow up patients for complications, and outcome (including quality of life) will be assessed six months after the operation. We will address two important questions about the efficacy and cost of risk reduction strategies. First, in patients at higher levels of risk and with a positive stress test, could a combination of medical therapy designed to protect the heart be as effective as current approaches, which include the performance of bypass surgery or coronary balloon angioplasty? Second, in patients identified as being at some risk - but low risk - are drugs sufficiently effective to avoid the need for further testing to quantify risk? As the population continues to age, the numbers of at risk patients undergoing major surgery will increase, and answers to these questions will provide important information to guide their management.Read moreRead less
The time of our lives: Time equity and the balancing of market and non-market production in the modern Australian population. This project will yield new information relevant to the national social inclusion agenda and the research priority goal of understanding and strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, fulfilling lives. Through a multilayered analysis of gender, class, life course stage, time allocation and the connection ....The time of our lives: Time equity and the balancing of market and non-market production in the modern Australian population. This project will yield new information relevant to the national social inclusion agenda and the research priority goal of understanding and strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, fulfilling lives. Through a multilayered analysis of gender, class, life course stage, time allocation and the connections between them, it will demonstrate links between various forms of social and economic participation and identify how they could be distributed more evenly. This knowledge is important to inform policy to better enable young people to become independent, families to both earn a living and care well for their children, and older people to be productive and socially engaged.Read moreRead less
Designing Gender Equality into the Future of Work. This project aims to investigate how women and men understand and experience the changing nature of work and their hopes and fears for the future. This project expects to generate new knowledge about the gendered dimensions of workplace change using an innovative and engaged research design that focuses on retail and the law, two areas where women are increasingly dominant, but which are located at distinct ends of the labour market. Expected ....Designing Gender Equality into the Future of Work. This project aims to investigate how women and men understand and experience the changing nature of work and their hopes and fears for the future. This project expects to generate new knowledge about the gendered dimensions of workplace change using an innovative and engaged research design that focuses on retail and the law, two areas where women are increasingly dominant, but which are located at distinct ends of the labour market. Expected outcomes of this project include an enhanced and coordinated capacity to build gender equality into the future of work. This should provide significant benefits such as better living standards for individuals and families and improved profitability and productivity for businesses. Read moreRead less
Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income familie ....Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income families. The direct involvement of child care providers in the research will strengthen its relevance and impact. This research will place Australia at the forefront of international research on local child care markets, and resulting improvements in ECEC policy and services will generate substantial economic and social benefits.Read moreRead less
Social transformation and international migration in the 21st century. Understanding the factors that shape international migration is crucial for Australia, because planned immigration remains a cornerstone of policy, yet traditional assumptions on the predominance of permanent settlement and the geographical controllability of movement are losing their validity. This project will help create the social scientific tools for new approaches to understanding migration and diversity at the global, ....Social transformation and international migration in the 21st century. Understanding the factors that shape international migration is crucial for Australia, because planned immigration remains a cornerstone of policy, yet traditional assumptions on the predominance of permanent settlement and the geographical controllability of movement are losing their validity. This project will help create the social scientific tools for new approaches to understanding migration and diversity at the global, regional and national levels. It will help Australian governments and civil society address new challenges in this field. It will also contribute to developing a highly-trained workforce for fundamental research on migration and social transformation. Read moreRead less
Social exclusion in adolescence: risks, assets, experiences and policy action. This project aims to investigate social exclusion among young people aged 8 to 17 including the risks of exclusion they face, the assets mobilised to support their inclusion and their life experiences in the context of these risks and assets. The project intends to investigate which risks, assets and experiences are most closely related to outcomes, and how these vary by age and gender. Expected outcomes include a new ....Social exclusion in adolescence: risks, assets, experiences and policy action. This project aims to investigate social exclusion among young people aged 8 to 17 including the risks of exclusion they face, the assets mobilised to support their inclusion and their life experiences in the context of these risks and assets. The project intends to investigate which risks, assets and experiences are most closely related to outcomes, and how these vary by age and gender. Expected outcomes include a new understanding of the relationship between social exclusion and outcomes in adolescence as well as entry points for policy intervention. Addressing social exclusion in adolescence will lead to improved outcomes in health, education and productivity, and a more socially-cohesive society.Read moreRead less