Role Of SPPL2A On B Cell Survival And Antibody Production In Mice And Humans
Funder
National Health and Medical Research Council
Funding Amount
$592,989.00
Summary
B lymphocytes are a specialised type of blood cells that produce antibodies in response to a pathogen or a vaccine. We have recently discovered that all mature B cells depend for their survival on a previously unknown protein called SPPL2A. This application will investigate the molecular mechanism through which SPPL2A contributes to the survival of B cells. We will also investigate if humans with currently unexplained B cell deficiency have mutations in SPPL2A.
Designing Gender Equality into the Future of Work. This project aims to investigate how women and men understand and experience the changing nature of work and their hopes and fears for the future. This project expects to generate new knowledge about the gendered dimensions of workplace change using an innovative and engaged research design that focuses on retail and the law, two areas where women are increasingly dominant, but which are located at distinct ends of the labour market. Expected ....Designing Gender Equality into the Future of Work. This project aims to investigate how women and men understand and experience the changing nature of work and their hopes and fears for the future. This project expects to generate new knowledge about the gendered dimensions of workplace change using an innovative and engaged research design that focuses on retail and the law, two areas where women are increasingly dominant, but which are located at distinct ends of the labour market. Expected outcomes of this project include an enhanced and coordinated capacity to build gender equality into the future of work. This should provide significant benefits such as better living standards for individuals and families and improved profitability and productivity for businesses. Read moreRead less
Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income familie ....Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income families. The direct involvement of child care providers in the research will strengthen its relevance and impact. This research will place Australia at the forefront of international research on local child care markets, and resulting improvements in ECEC policy and services will generate substantial economic and social benefits.Read moreRead less
Inequality in first family formation in contemporary Australia. The timing and context of Australians' entry into parenthood differs across the socio-economic spectrum. This project investigates the socio-economic disparities in entering parenthood, particularly focusing on education and employment differentials as well as socio-demographic factors such as ethnic and religious background, and experience of family dissolution. Using longitudinal panel data, this project aims to: determine the soc ....Inequality in first family formation in contemporary Australia. The timing and context of Australians' entry into parenthood differs across the socio-economic spectrum. This project investigates the socio-economic disparities in entering parenthood, particularly focusing on education and employment differentials as well as socio-demographic factors such as ethnic and religious background, and experience of family dissolution. Using longitudinal panel data, this project aims to: determine the socio-economic and demographic differentials of inequality in first family formation in Australia; discover how inequality in first family formation has changed since the middle of the 20th Century; and, assess how family-policy regime mediates or exacerbates this inequality.Read moreRead less
Women in Local Government: Understanding their Political Trajectories. This project aims to investigate the chronic under representation of women in Australian politics through a local government lens. It expects to generate new knowledge about barriers to female political representation, their political performance and pathways to higher tiers of elected office. By following men and women councillors across an election cycle, this research seeks to robustly compare and measure women's experienc ....Women in Local Government: Understanding their Political Trajectories. This project aims to investigate the chronic under representation of women in Australian politics through a local government lens. It expects to generate new knowledge about barriers to female political representation, their political performance and pathways to higher tiers of elected office. By following men and women councillors across an election cycle, this research seeks to robustly compare and measure women's experiences of local politics to develop a new framework to map and address obstacles preventing political equity. Expected outcomes include theoretical advances and a 'best practice' guide for achieving parity.This should provide significant public benefits by advancing female participation across all levels of governments.
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Challenging the neoliberal critique of deficit spending and public debt. This project aims to analyse the rhetoric of balanced budgets by examining its intellectual and political history and revisiting counterarguments. Expected outcomes from the project will include insights into the development of rhetoric based on analysis of archival, textual and interview-based data . Findings from the project will be published in online fora with wide readership in national and international policy circle ....Challenging the neoliberal critique of deficit spending and public debt. This project aims to analyse the rhetoric of balanced budgets by examining its intellectual and political history and revisiting counterarguments. Expected outcomes from the project will include insights into the development of rhetoric based on analysis of archival, textual and interview-based data . Findings from the project will be published in online fora with wide readership in national and international policy circles. The project has the capacity to provide insights into and benefits for policy discourse on government deficit-spending and public debt.Read moreRead less
Special Research Initiatives - Grant ID: SR0354580
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible ....Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible responses to the challenge of creating sustainable societies in a changing world. Through a greater understanding of past societies' reactions to rapid environmental change, the Network will build on existing leading edge research and create a more informed guide to a sustainable future.Read moreRead less
Tracking 3000 years of agricultural adaptation to the resource poor, climate sensitive and remote Solomon Islands using biomarkers and palaeoecology. Establishing research programs with Pacific neighbours benefits Australia's relations with Pacific Island countries generally. This project applies novel research methods to understanding human adaptations to long-term environmental and climatic fluctuations. It will address the National Research Priority goal of responding to climate variability b ....Tracking 3000 years of agricultural adaptation to the resource poor, climate sensitive and remote Solomon Islands using biomarkers and palaeoecology. Establishing research programs with Pacific neighbours benefits Australia's relations with Pacific Island countries generally. This project applies novel research methods to understanding human adaptations to long-term environmental and climatic fluctuations. It will address the National Research Priority goal of responding to climate variability by advancing our understanding of recent climate change in the Australia/Pacific region. It will show that Australian researchers can play a significant role in understanding the spread of humans across the Pacific, and the environmental adaptations required by populations in resource depleted environments. It will increase collaboration between research institutions focusing on the Australia/Pacific region.Read moreRead less
Improving the Well-Being of Low Socioeconomic Status Students at University. This project aims to investigate a new approach to improving the mental well-being of university students from low socioeconomic status (SES) backgrounds. University students have a high risk of experiencing mental health problems, and students from low SES backgrounds have a particularly high risk. This project aims to investigate university-relevant Facebook groups as a method of improving the mental well-being of low ....Improving the Well-Being of Low Socioeconomic Status Students at University. This project aims to investigate a new approach to improving the mental well-being of university students from low socioeconomic status (SES) backgrounds. University students have a high risk of experiencing mental health problems, and students from low SES backgrounds have a particularly high risk. This project aims to investigate university-relevant Facebook groups as a method of improving the mental well-being of low SES students by improving their online social integration at university. Expected outcomes and benefits include a scalable, low-cost approach to reducing an SES inequality that costs Australia billions of dollars each year.Read moreRead less
Using fossil insects and plants to recognise past human impacts on Pacific island biodiversity. This project will enhance our ability to characterise human impact on island biodiversity. It will develop novel research methods that can be applied in the Australian context to understand changes in biodiversity that come with human impact. The contemporary emphasis on biosecurity in the protection of Australia's unique environment against human-introduced exotic pests and diseases can be better und ....Using fossil insects and plants to recognise past human impacts on Pacific island biodiversity. This project will enhance our ability to characterise human impact on island biodiversity. It will develop novel research methods that can be applied in the Australian context to understand changes in biodiversity that come with human impact. The contemporary emphasis on biosecurity in the protection of Australia's unique environment against human-introduced exotic pests and diseases can be better understood in the context of past introductions. Our project will demonstrate the role Australian archaeologists and natural scientists can play in understanding the spread of humans across the Pacific and the environmental consequences of colonisation. It will increase collaboration between research institutions in the Australia/Pacific region.Read moreRead less