Magnetic Resonance Imaging Of Structural And Functional Connectivity In Lesion-negative Temporal Lobe Epilepsy Compared To Hippocampal Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$99,883.00
Summary
Epileptic seizures in the temporal lobe of the brain can affect how the temporal lobe connects to other brain regions. We are using new MRI techniques to investigate these altered connections, in patients who have no other abnormality on their brain scans. Our aim is to find distinctive patterns of altered connectivity, which will help us better understand this type of epilepsy.
Ischaemic Stroke And Atrial Fibrillation: Development Of A Novel Artificial Intelligence System Using Magnetic Resonance Imaging
Funder
National Health and Medical Research Council
Funding Amount
$92,335.00
Summary
Atrial fibrillation (AF) is an abnormal heart rhythm which is a common cause of stroke. AF can often go unrecognized as patients may have no symptoms. This project aims to develop computer software which can automatically detect underlying AF based on MRI brain scan pattern, in patients who have had an acute stroke. This project has the potential to offer several benefits, including reduced need for costly investigations, improved AF detection and a larger pool of patients being treated for AF.
Using Diffusion MRI For Understanding The Relationship Between Memory Decline And Corticothalamic Tracts
Funder
National Health and Medical Research Council
Funding Amount
$57,578.00
Summary
Stroke populations are at a risk of dementia. Structural changes have been demonstrated to precede cognitive changes, providing a potential for early diagnosis and intervention. Magnetic resonance imaging markers of structural connectivity are powerful predictors of dementia. As a longitudinal study, this proposal has the unique advantage that I will be able to detect changes in post-stroke brain networks in the 3 years after stroke. This raises the potential for future clinical application.
Novel Cardiac Imaging Modalities And Biomarkers In Acute Decompensated Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$100,926.00
Summary
Heart failure (an inability of the heart to meet the bodyÍs metabolic requirements) is a major public health burden with high rates of death, hospitalisation, and reduced quality of life. Further research is required to investigate the underlying mechanisms. This project will analyse abnormalities in heart structure and function using new techniques in heart ultrasound and magnetic resonance imaging, and blood tests. Findings in this study may help to guide the development of future therapies to ....Heart failure (an inability of the heart to meet the bodyÍs metabolic requirements) is a major public health burden with high rates of death, hospitalisation, and reduced quality of life. Further research is required to investigate the underlying mechanisms. This project will analyse abnormalities in heart structure and function using new techniques in heart ultrasound and magnetic resonance imaging, and blood tests. Findings in this study may help to guide the development of future therapies to improve outcomes in patients with heart failure.Read moreRead less
Stroke is a major cause of death and disability in adult across the world. Understanding how exactly brain cells are affected in stroke and how they are injured, and how they response to treatment is important in order to develop new treatment to maximize recovery and minimize brain injury after stroke. This project uses advanced MRI being performed at several time points after a stroke to study how the brain tissues recovers or dies after a stroke.
Overcoming Radiation Resistance In Glioblastoma With Novel Metabolic Modulations
Funder
National Health and Medical Research Council
Funding Amount
$62,554.00
Summary
Aim 1 is to document the pathological, surgical, radiotherapy and chemotherapy patterns of care in the Australian setting using the AGOG (Australian Genomics and Clinical Outcomes of Glioma) database. The second aim to develop non-invasive imaging biomarkers which can be used to monitor treatment efficacy. The third aim is to improve outcomes using drug and radiation combination therapy. in the treatment of high grade gliomas.
Altered Sense Of Identity In Dementia: Cognitive And Neurobiological Underpinnings
Funder
National Health and Medical Research Council
Funding Amount
$108,902.00
Summary
People with dementia commonly experience changes in their sense of identity, causing significant distress for the individual and their families. This project will investigate these changes comprehensively, determining their contributing factors and how they relate to dementia’s effect on the brain. Outcomes from this project will improve understanding of the experience of the person with dementia, informing personalised care and enhancing the quality of patient-carer relationships.
The Haemodynamic Effects Of Cardiac Compression By Large Hiatal Hernia And The Relationship To Exercise Impairment.
Funder
National Health and Medical Research Council
Funding Amount
$117,270.00
Summary
Large hiatal herniae (HH) often cause debilitating exercise intolerance - the mechanism of which is unknown. This project will define the functional and haemodynamic significance of cardiac compression in patients with large HH, providing new insights into the mechanism of exercise impairment in these patients as well as clinical tools for pre-operative selection of patients likely to benefit most from surgical repair.
Structural And Functional Correlates In Adult Congenital Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$89,699.00
Summary
Survival in congenital heart disease patients has improved. Despite long-term sequelae, evidence is scarce. We aim to correlate structural cardiac features on MRI in adults with exercise capacity to determine predictors of poor outcome. Non-compaction cardiomyopathy ("spongy" heart) is a rare, unclassified form of heart failure. The incidence is much higher in patients with congenital heart disease. We aim to examine the causes, mechanical consequences and its effects on cardiac electrical condu ....Survival in congenital heart disease patients has improved. Despite long-term sequelae, evidence is scarce. We aim to correlate structural cardiac features on MRI in adults with exercise capacity to determine predictors of poor outcome. Non-compaction cardiomyopathy ("spongy" heart) is a rare, unclassified form of heart failure. The incidence is much higher in patients with congenital heart disease. We aim to examine the causes, mechanical consequences and its effects on cardiac electrical conduction to understand this undefined entity.Read moreRead less
Catheter Ablation For AF In Heart Failure: Can MRI Predict Benefit?
Funder
National Health and Medical Research Council
Funding Amount
$143,676.00
Summary
This proposal aims to evaluate the role of catheter ablation for atrial fibrillation in patients with heart failure. We hyopthesise that cardiac MRI will be a useful stratification tool in identifying which patients are likely to benefit from catheter ablation, namely by the absence of significant fibrosis. We propose a randomised cardiac MRI guided multi-centre trial to ascertain the benefit of catheter ablation as an effective treatment of heart failure in such patients.