Macrophages, Cytokines And The Inflammatory Response (Reappointment To Senior Principal Research Fellow)
Funder
National Health and Medical Research Council
Funding Amount
$898,008.00
Summary
The project will continue to explore how a type of white blood cell contributes to the pathology associated with chronic inflammatory diseases, such as rheumatoid arthritis, heart disease, atherosclerosis, multiple sclerosis and periodontal disease. Success already has been achieved in that clinical trials in rheumatoid arthritis have emanated from this project.
Translating Research Into HIV-related Health Outcomes In The Developing World
Funder
National Health and Medical Research Council
Funding Amount
$714,745.00
Summary
Professor Crowe's research addresses important health issues for HIV infected people living in resource limited countries. Her team validates low cost point of care tests to monitor HIV infection, including a test she co-developed to determine when to start anti-HIV treatment, and investigates how these low cost tests can improve clinical care of people with HIV and TB. In addition she will determine how changes in the immune system increase the risk of heart attacks in young HIV patients.
Mechanistic And Translational Studies Targeting Kidney Inflammation And Fibrosis.
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
The progression of kidney disease to end-stage renal failure requires support by dialysis or kidney transplantation, leading to reduced quality of life, loss of productivity, and the huge cost of renal replacement therapy in Australia ($1 billion in 2010). This research program focuses on two areas; advancing our understanding of the basic mechanisms of disease pathogenesis, and working with commercial partners to translate my current research effort towards new therapies for kidney disease.
I am a cellular immunologist interested in the study of cytokines and other regulatory molecules in inflammatory and immune responses. One key area relates to the effect on sunlight on cell-mediated immunity.
Toll-like Receptors And Innate Immunity: Genes And Pathways Regulating Infectious And Inflammatory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$138,367.00
Summary
The innate immune system is the first line of defence against infectious diseases, but also contributes to the pathology of inflammatory diseases (e.g. rheumatoid arthritis). I study specific genes and pathways used by the innate immune system to (1) understand how the innate immune system prevents infections and how microorganisms overcome these defences, and (2) develop approaches to block inflammation. Outcomes may include new therapies for inflammatory and infectious diseases.