Double Exposure Photoresists for the 32 and 22 nm Lithographic Nodes. The semiconductor industry is one of the largest world-wide, with annual revenue of $220B and employing over 1.5M people around the world. This project provides a unique opportunity for development within Australia of significant expertise in the field of double exposure lithography. The novel photoactive polymeric films to be developed are expected to support the next generation of microchips. A major outcome of this project ....Double Exposure Photoresists for the 32 and 22 nm Lithographic Nodes. The semiconductor industry is one of the largest world-wide, with annual revenue of $220B and employing over 1.5M people around the world. This project provides a unique opportunity for development within Australia of significant expertise in the field of double exposure lithography. The novel photoactive polymeric films to be developed are expected to support the next generation of microchips. A major outcome of this project will be establishment of Australia as a world-leader in this rapidly expanding field. Furthermore the technology can be applied broadly to many printing technologies.Read moreRead less
Advanced Lithographic Solutions using Block Copolymers: Integrating Self Assembly and Lithography. The semiconductor industry is one of the largest world-wide, with annual revenue of $220B and employing over 1.5M people around the world. This project provides a unique opportunity for development within Australia of significant expertise in the field of self assembly in photolithography. Plastics with tailored properties will be made and used to develop novel processes to reduce the defectivity i ....Advanced Lithographic Solutions using Block Copolymers: Integrating Self Assembly and Lithography. The semiconductor industry is one of the largest world-wide, with annual revenue of $220B and employing over 1.5M people around the world. This project provides a unique opportunity for development within Australia of significant expertise in the field of self assembly in photolithography. Plastics with tailored properties will be made and used to develop novel processes to reduce the defectivity in integrated circuit manufacture. The ultimate benefit will be faster and more energy efficient microprocessors. A major outcome of this project will be establishment of Australia as a world-leader in this rapidly expanding field. Furthermore, the technology can be applied broadly to many other applications such as high density data storage.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775481
Funder
Australian Research Council
Funding Amount
$304,000.00
Summary
X-ray Molecular Structure Elucidation Facility (MSEF). X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-the-art re ....X-ray Molecular Structure Elucidation Facility (MSEF). X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-the-art research and training facilities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882576
Funder
Australian Research Council
Funding Amount
$588,000.00
Summary
Polymer Characterization Facility (PCF). Future development of macromolecular and biotechnologies have the potential to revolutionize everyday life. Current applications include plastics for engineering, diagnostic devices for biochemical analysis, polymer therapeutics for drug delivery and prosthesis with specific functions. The proposed facility will provide the analytical tools required to probe and develop advanced materials with application in medicine, agriculture, composites, cosmetics, ....Polymer Characterization Facility (PCF). Future development of macromolecular and biotechnologies have the potential to revolutionize everyday life. Current applications include plastics for engineering, diagnostic devices for biochemical analysis, polymer therapeutics for drug delivery and prosthesis with specific functions. The proposed facility will provide the analytical tools required to probe and develop advanced materials with application in medicine, agriculture, composites, cosmetics, communications and electronics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237664
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT- ....High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT-ICR-MS will provide key structural information on a wide range of synthetic and natural chemical substances, including sequence (e.g. peptides) and fragmentation patterns, while the MALDI-TOF instrument will be used primarily for high through-put proteomic analyses.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989336
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are ....The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are critical for the competitiveness of Australian industry, national productivity and economic growth. This application seeks to provide a facility for multidisciplinary scientific development that will enhance academic-industrial collaboration. This will position SA research community for scientific breakthroughs that benefit the Australian community.Read moreRead less
Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal w ....Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal will receive international recognition and will encourage more research in this field, attracting international funding, and create new research opportunities. Read moreRead less
Membrane-associated structure and the effect of metals on Abeta peptide from Alzheimer's disease. Alzheimer's disease currently affects 5% of Australians over 65, and will triple by year 2050 without an effective therapy. Much research to understand the causes of the disease has focused on the distinctive amyloid deposits found in patients' cerebral tissue. Recent evidence suggests that nerve cell death is actually directly caused by soluble forms of the protein fragments and metals that form th ....Membrane-associated structure and the effect of metals on Abeta peptide from Alzheimer's disease. Alzheimer's disease currently affects 5% of Australians over 65, and will triple by year 2050 without an effective therapy. Much research to understand the causes of the disease has focused on the distinctive amyloid deposits found in patients' cerebral tissue. Recent evidence suggests that nerve cell death is actually directly caused by soluble forms of the protein fragments and metals that form these deposits. We will investigate the specific molecular structure of these fragments with metals in relation to vesicles which mimic the nerve cell surface. This information may facilitate future biomedical efforts work to develop therapies, as well as develop general techniques to study similar structural problems.Read moreRead less
Molecular grafting methods for design of peptide therapeutics. This project has the potential to lead to major economic benefits to Australia via royalty returns from novel drugs. Extra economic benefits derive from a reduction in the cost of treatment of diseases. The development of a new Australian developed peptide drug thus has the potential to lead to multimillion dollar savings to the Australian economy. Finally the project will provide training in state-of-the-art drug design that will e ....Molecular grafting methods for design of peptide therapeutics. This project has the potential to lead to major economic benefits to Australia via royalty returns from novel drugs. Extra economic benefits derive from a reduction in the cost of treatment of diseases. The development of a new Australian developed peptide drug thus has the potential to lead to multimillion dollar savings to the Australian economy. Finally the project will provide training in state-of-the-art drug design that will enhance Australia's pharmaceutical industry generally.Read moreRead less
New approaches to functional and structural genomics. Genome sequencing has revealed complete sets of macromolecules that make up our cells. We now need to learn how these macromolecules work together in a coordinated fashion. The proposed research will lead to the discovery of new biological molecules, interactions and processes essential for the function of cells, identify new therapeutic targets and strategies to combat disease, identify new concepts in bio- and nanotechnology, and train new ....New approaches to functional and structural genomics. Genome sequencing has revealed complete sets of macromolecules that make up our cells. We now need to learn how these macromolecules work together in a coordinated fashion. The proposed research will lead to the discovery of new biological molecules, interactions and processes essential for the function of cells, identify new therapeutic targets and strategies to combat disease, identify new concepts in bio- and nanotechnology, and train new interdisciplinary researchers. It will underpin the National Research Priorities (Frontier Technologies for Building and Transforming Australian Industries, and Promoting and Maintaining Good Health) and help Australia capitalise on a plethora of opportunities for future economic and health benefits.Read moreRead less