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Confinement of space based on association of water soluble container molecules. The proposed research addresses the use of water soluble bowl shaped molecules or ions (cavitands) in conjunction with metal ions and crown ether and related cryptand molecules to form molecular capsules, two or more of the components being pre-programmed to assemble thus. The new materials will be unique in supramolecular chemistry, with the associated architectures bearing on materials science, molecular electronic ....Confinement of space based on association of water soluble container molecules. The proposed research addresses the use of water soluble bowl shaped molecules or ions (cavitands) in conjunction with metal ions and crown ether and related cryptand molecules to form molecular capsules, two or more of the components being pre-programmed to assemble thus. The new materials will be unique in supramolecular chemistry, with the associated architectures bearing on materials science, molecular electronics, separation sciences, and drug delivery. The new range of water soluble container molecules that will become accessible as part of this proposal, promises new applications in these areas.Read moreRead less
Crowns, cages and cavities: Insights into host-guest chemistry from experimental charge density analysis of supramolecular crystals. Supramolecular systems - molecular aggregates - underpin the design and development of materials for a vast number of potential applications, in areas as diverse as catalysis, targeted drug delivery, gas storage, chemical separation, electro-optics and nonlinear optics. They also serve as models for complex phenomena such as self-assembly and ligand-receptor bindin ....Crowns, cages and cavities: Insights into host-guest chemistry from experimental charge density analysis of supramolecular crystals. Supramolecular systems - molecular aggregates - underpin the design and development of materials for a vast number of potential applications, in areas as diverse as catalysis, targeted drug delivery, gas storage, chemical separation, electro-optics and nonlinear optics. They also serve as models for complex phenomena such as self-assembly and ligand-receptor binding. Outcomes will impact on several of the nation's articulated research priorities and, through involvement of postdoctoral fellows and postgraduate students in an international collaboration of this nature, the project contributes directly to producing graduates and researchers familiar with state-of-the-art experimental facilities, both within Australia and overseas.Read moreRead less
Lowering the barriers to a hydrogen technology: What slows proton conductors? When hydrogen burns the only product is water, therefore making it the most attractive form of clean energy. Central to the technological use of hydrogen is the need for a material through which only this element can pass, both so that the energy can be extracted and for purification. At present high temperatures are needed to allow hydrogen to pass through solids that exhibit this sieving property. Through state of th ....Lowering the barriers to a hydrogen technology: What slows proton conductors? When hydrogen burns the only product is water, therefore making it the most attractive form of clean energy. Central to the technological use of hydrogen is the need for a material through which only this element can pass, both so that the energy can be extracted and for purification. At present high temperatures are needed to allow hydrogen to pass through solids that exhibit this sieving property. Through state of the art computational methods the movement through these materials can be observed so that the regions that slow the hydrogen down can be identified. From this understanding it will be possible to design more efficient ways of producing energy that can provide clean air for cities and reliable power for remote communities.Read moreRead less
Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression. RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The ....Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression. RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The current study will investigate the structural and biophysical properties of a recently discovered HuR/PCBP/mRNA complex implicated in the regulation of androgen receptor expression. This information has the potential to assist in the development of drugs to reduce AR expression in prostate cancer.Read moreRead less
Integrated approach to self assembled molecular capsules. Process intensification technologies in the form of spinning disc and rotating tube processing are new to Australia and present many opportunities for both carrying out the synthesis of organic compounds and in fabricating nanomaterials. The ensuing nanotechnological applications are more benign in approach then other fabrication techniques, minimising the generation of waste at the same time under continuous flow which is likely to be mo ....Integrated approach to self assembled molecular capsules. Process intensification technologies in the form of spinning disc and rotating tube processing are new to Australia and present many opportunities for both carrying out the synthesis of organic compounds and in fabricating nanomaterials. The ensuing nanotechnological applications are more benign in approach then other fabrication techniques, minimising the generation of waste at the same time under continuous flow which is likely to be more attractive to industry. Proposed applications such as drug delivery, catalysis, smart materials and device technology are expected to foster industrial collaborations. The project will provide first-rate research training and promote Australian science through the development of these new technologies.Read moreRead less
Advanced bio-inspired polymer assembly: tools for diagnostics, imaging and therapies. ‘Smart’ polymeric materials have the potential to make a significant impact in areas such as healthcare. However, to do this effectively the materials will need to respond intelligently to biological signals. This project will involve the synthesis and application of ‘smart’ polymer films and particles, which mimic biological behaviour.
Calcification of acrylic hydrogels in abiotic media: mechanism and control. Poly(2-hydroxyethyl methacrylate (PHEMA) and other acrylic hydrogels are extensively used as biomaterials, yet conclusive evidence exists that they have a propensity to calcify following implantation. This process has undesirable consequences on the functionality of various prostheses. Based on preliminary observations that PHEMA can promote the deposition of calcium minerals from media devoid of biological factors, whic ....Calcification of acrylic hydrogels in abiotic media: mechanism and control. Poly(2-hydroxyethyl methacrylate (PHEMA) and other acrylic hydrogels are extensively used as biomaterials, yet conclusive evidence exists that they have a propensity to calcify following implantation. This process has undesirable consequences on the functionality of various prostheses. Based on preliminary observations that PHEMA can promote the deposition of calcium minerals from media devoid of biological factors, which appears thus to be an inherent property of the polymer, the project aims at formulating new hypotheses to explain this phenomenon, and to confirm them experimentally. The "chelation" hypothesis will be validated by modifying the structure of polymers, and the "spontaneous precipitation" hypothesis by assessing the effect of solutes on the equilibrium water content of polymers. NMR and FTIR spectrometric techniques will be used to gain further insight into the mechanism of calcification. Methods to prevent the calcification will potentially result from these experiments, however, anticalcification agents will also be incorporated into hydrogels and their effect evaluated in calcification assays.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100112
Funder
Australian Research Council
Funding Amount
$348,575.00
Summary
Design and synthesis of new radical and heterometallic magnetic molecules. This project aims to build upon recent advances in developing magnetic molecules for use in electronic devices. The development of new electronic devices based on quantum systems will lead to the development of faster more efficient computers. Magnetic molecules are promising candidates for the data storage components in these systems. Despite the potential of these materials, the temperature at which they operate needs t ....Design and synthesis of new radical and heterometallic magnetic molecules. This project aims to build upon recent advances in developing magnetic molecules for use in electronic devices. The development of new electronic devices based on quantum systems will lead to the development of faster more efficient computers. Magnetic molecules are promising candidates for the data storage components in these systems. Despite the potential of these materials, the temperature at which they operate needs to be increased above that of liquid helium. This project is focused on the development of new magnetic lanthanide molecules with higher working temperatures. The outcomes will provide a greater understanding of how structure impacts on the magnetic properties of the molecule.Read moreRead less
Controlling the organisation of matter using vortex fluidics. Vortex fluidic devices will be developed and used to construct functional complex molecules and materials, and probe the structure of self assembled systems. The scalable processing will be assessed for application in advanced materials production, the chemical industry and in developing complex molecules for drug discovery.