Optimizing Implanted Cell Survival Using A Tissue Engineering Model
Funder
National Health and Medical Research Council
Funding Amount
$589,175.00
Summary
Cell therapy and tissue engineering involve the insertion of specific cells into damaged tissues or into a bioraector in a patient's body to generate new replacement tissues. This project seeks to improve two factors associated with inserting cells : 1. The innate survival characteristics of the cells being inserted, and 2. The blood vessel supply at the site of insertion. These techniques will greatly improve the survival of inserted cells.
Characterization Of The FHL Protein Family In Striated Muscle
Funder
National Health and Medical Research Council
Funding Amount
$500,750.00
Summary
This grant examines the role of a family of muscle proteins, called FHL proteins, in skeletal and heart muscle. Inherited muscular disorders such as muscular dystrophy and myopathies, cause muscle weakness, which may be profound and lead to premature death due to respiratory muscle failure, or cause mild weakness later in life. The proteins which are defective in these muscular dystrophies are structural muscle proteins, which link and stabilize the contractile fibres in muscle and protect the m ....This grant examines the role of a family of muscle proteins, called FHL proteins, in skeletal and heart muscle. Inherited muscular disorders such as muscular dystrophy and myopathies, cause muscle weakness, which may be profound and lead to premature death due to respiratory muscle failure, or cause mild weakness later in life. The proteins which are defective in these muscular dystrophies are structural muscle proteins, which link and stabilize the contractile fibres in muscle and protect the muscle from the stresses and damage resulting from repeated muscular contraction. We have identified that the FHL proteins, which are the focus of this grant application, bind to and potentially regulate muscle proteins, which have been shown to cause forms of muscular dystrophy and cardiomyopathy. Examination of these interactions will provide insights into the biological mechanism of these muscle disorders. Furthermore, one of these proteins, FHL1 is significantly increased in hypertrophic cardiomyopathy, heart muscle thickening, a major cause of sudden cardiac death in young adults. We are creating transgenic mice, which make increased levels of FHL1 protein in their heart muscle, to determine whether increased FHL1, by itself is sufficient to promote heart muscle thickening. These studies should lead to further understanding of the development of diseases of heart and skeletal muscle, which may lead to novel treatments in the future.Read moreRead less
Maintenance of skeletal muscle integrity is critical for normal locomotor function. During adulthood skeletal muscle mass and strength is progressively lost which leads to locomotor impairment common in the elderly. Loss of skeletal muscle may also contribute to functional impairment in patients with inherited disorders of the scaffolding connective tissue that hold muscle fibres together, such as Duchenne's dystrophy. Understanding the biology of muscle cell growth and responses to environmenta ....Maintenance of skeletal muscle integrity is critical for normal locomotor function. During adulthood skeletal muscle mass and strength is progressively lost which leads to locomotor impairment common in the elderly. Loss of skeletal muscle may also contribute to functional impairment in patients with inherited disorders of the scaffolding connective tissue that hold muscle fibres together, such as Duchenne's dystrophy. Understanding the biology of muscle cell growth and responses to environmental stresses such as exercise and ageing is, therefore, critical to healthy daily functioning. In preliminary studies we have defined a novel biochemical pathway which we believe underlies the ability of muscle to grow larger and stronger. In this application, we propose to rigorously evaluate the role of this pathway in muscle growth by experiments performed both with cell culture models and in animals. The findings of this study would have direct therapeutic benefit for a large number of major clinical conditions, such as heart failure, age-related muscular weakness and muscle diseases.Read moreRead less
Australian Council Of Prawn Fishers Industry Partnership Agreement - Environment RD&E Program
Funder
Fisheries Research and Development Corporation
Funding Amount
$1,103,000.00
Summary
Australia's commitment to 30% of marine protected area by 2030 in response to global concern about ocean health has focussed scrutiny directly on Australia's commercial net fishing sector. The handling of the Macquarie Island Marine Park announcement followed by the closure of gill net fishing in Qld in 2023 and marine protection proposals in WA have all challenged the commercial fishing sector's reliance on objective, risk based, scientific fisheries management and resource allocation. The fo ....Australia's commitment to 30% of marine protected area by 2030 in response to global concern about ocean health has focussed scrutiny directly on Australia's commercial net fishing sector. The handling of the Macquarie Island Marine Park announcement followed by the closure of gill net fishing in Qld in 2023 and marine protection proposals in WA have all challenged the commercial fishing sector's reliance on objective, risk based, scientific fisheries management and resource allocation. The focus on the commercial fishing sector appears incongruous to Australia’s effectiveness addressing greater impacts on coastal and marine health as identified in the five yearly Statement of Environment reports.
Australia's prawn trawl sector must continue its front-footed environmental stewardship actions to address Net Zero targets and the proposed Nature Positive Act. The ACPF must now build on its transparent community engagement activity with further investment as evidence of the sector's priorities. The ACPF's concerted community engagement activity commenced under FRDC Project 2018/172 and continued under the ACPF's 2021-2026 Community Engagement Plan. The sector must continue to actively reduce trawl impact at the same time as demonstrate its outstanding sustainability credentials as a food supplier.
The project invests within the scope of the FRDC's Environment Program with delivery into Communities, People, Adoption and Industry Programs. The project delivers on the following ACPF RD&E strategic activities against ACPF's Strategic Goals:
Strategic activity: Reduce impacts of fishing on bycatch and the marine environment (and continue to identify environmental risks to natural resource access). ACPF + cross-jurisdiction. (Delivering against Goal 1: Sustainability; Ecological. Goal 2: Stewardship marine resources. Goal 5: Society and Consumers trust, respect and value.)
Strategic activity: Co-investment opportunities in ecosystem health, climate change, carbon footprint. (Delivering against Goal 2: Stewardship of marine and aquatic environments)
Strategic activity: Best practice/Responsible fishing practices communication. (Delivering against Goal 2: Stewardship of marine and aquatic environments)
Strategic activity: Profile RD&E addressing social licence risks. (Delivering against Goal 1: Sustainability; Social. Goal 2: Stewardship marine resources and aquatic environments. Goal 3. A culture that is inclusive and forward thinking. Goal 4. Fair, equitable and secure access. Goal 5: Society and Consumers trust, respect and value.)
The project proposes to collate baseline data, invests in trawl impact RD&E, invests in nature positive initiatives across the environment metrics of the ESG framework and communicates all in a way that engages identified audiences.
The project will contain subprojects which will be identified and scoped in line with the overarching project strategy. Applications for subprojects will be sought using a range of mechanisms - competitive applications, direct or select tender as recommended by the project's steering committee (industry representatives, FRDC, an eNGO and a technical expert). Subprojects seeking national funding must demonstrate Return on Investment to a significant proportion of the sector. Subprojects will be contracted by the ACPF and report deliverables to the FRDC.
Co-investment will be sought from stakeholder partners and/or made by the project into externally managed projects. Objectives: 1. Australian wild prawn sector is Ecologically, Economically and Socially sustainable through pursuing low impact, fuel efficient and financially viable prawn trawl gear technology 2. Australian wild prawn sector plays a critical lead role in the stewardship of our marine resources seeking partnership with stakeholders 3. Through strategic co-investment to address threats on the horizon, the Australian wild prawn sector invests in new innovation that enables fair, equitable and secure access to marine resources 4. Australian society and consumers trust, respect and value the Australian wild prawn sector and its product achieved via its stewardship 5. The Australian wild prawn sector's people are equipped to adapt to climate challenges and the environmental performance standards required of all marine users Read moreRead less
On the mechanism of boiling instability in microchannels. This project will enable designers to create highly efficient miniaturised devices based on the boiling of fluids such as water or organics. These devices include micro-power generation systems, coolers for computer chips and solar collectors, and micro-chemical process systems. Such devices provide environmental, safety and economic benefits.