Hydrostatic Pressure Distributions In Peri-pharyngeal Tissues : Impact On Upper Airway Patency
Funder
National Health and Medical Research Council
Funding Amount
$508,935.00
Summary
The obstructive sleep apnoea hypopnoea syndrome (OSAHS) refers to a condition in which throat blockage occurs during sleep leading to breathing difficulties, including cessation of breathing for short periods of time. OSAHS affects both men and women but is amongst the commonest of chronic disorders of adult males, occurring in ~4% of men over the age of 45 years. In the proposed studies we will develop a computer model of the function of the throat during breathing. A particular focus of our mo ....The obstructive sleep apnoea hypopnoea syndrome (OSAHS) refers to a condition in which throat blockage occurs during sleep leading to breathing difficulties, including cessation of breathing for short periods of time. OSAHS affects both men and women but is amongst the commonest of chronic disorders of adult males, occurring in ~4% of men over the age of 45 years. In the proposed studies we will develop a computer model of the function of the throat during breathing. A particular focus of our model will be the influence of the properties of the tissue that form the walls of the throat. Our goal is to construct a computer model that will be useful in identifying specific features of throat function that make people susceptble to the development of OSAHS. In this manner we hope to provide a tool that can be used to develop new approaches to the treatment and prevention of OSAHS.Read moreRead less
BioPolymer Fibres For Remodelling Mdx And Damaged Muscle
Funder
National Health and Medical Research Council
Funding Amount
$527,286.00
Summary
This project aims to generate new, smart polymers for use in re-building muscle that has degenerated due to disease and-or trauma damage. The merger of smart polymers with biologically based solutions and cells has great potential to improve outcomes of treatments of damaged muscle in diseases such as Muscular Dystrophy.
The Effects Of Tonic Muscle Pain On The Sympathetic And Somatic Motor Systems In Human Subjects
Funder
National Health and Medical Research Council
Funding Amount
$462,948.00
Summary
The main objective of this proposal is to reveal the effects of nociceptive reflexes in humans, and thus identify their functional and clinical implications. By performing invasive recordings from the nerves that control blood vessels and muscles in healthy volunteers subjected to long-lasting (~1 hour) experimental pain, this work will increase our understanding of the adaptive changes that pain induces and improve treatments to prevent pain from becoming chronic.
Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate model ....Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate models, which will be designed to allow the partner organisation to undertake further hemodynamic research.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101098
Funder
Australian Research Council
Funding Amount
$374,200.00
Summary
New mathematical theory for fluid motion on surfaces with holes. This project aims to develop new explicit mathematical results to enhance the understanding of potential theory – a fundamental area of mathematics - on surfaces with complicating geometrical properties. There are very few such fundamental results on complicated curved surfaces, such as those with holes. This project should provide a toolbox for solving many different mathematical problems on curved surfaces. The new results should ....New mathematical theory for fluid motion on surfaces with holes. This project aims to develop new explicit mathematical results to enhance the understanding of potential theory – a fundamental area of mathematics - on surfaces with complicating geometrical properties. There are very few such fundamental results on complicated curved surfaces, such as those with holes. This project should provide a toolbox for solving many different mathematical problems on curved surfaces. The new results should also have application to the analysis of fluid flows over porous media and practical engineering structures.Read moreRead less
Force Interactions in Packed and Fluidised Beds at Micro-Scale Operation. Industrial processing in the 20th century was about increasing size to gain benefit from economies of scale. This century, the focus is on micro devices like lab-on-a-chip and high speed computer processors that deliver their product directly to the consumer. There are significant obstacles facing this new technology. Mixing is reduced due to laminar flow, and a large amount of energy is needed to move the fluid through su ....Force Interactions in Packed and Fluidised Beds at Micro-Scale Operation. Industrial processing in the 20th century was about increasing size to gain benefit from economies of scale. This century, the focus is on micro devices like lab-on-a-chip and high speed computer processors that deliver their product directly to the consumer. There are significant obstacles facing this new technology. Mixing is reduced due to laminar flow, and a large amount of energy is needed to move the fluid through such small devices. Particles are often added to improve mixing and heat transfer, but their presence adds to the energy requirements. This study will help us overcome these challenges. Read moreRead less
Particle scale modelling of dense medium cyclones in coal preparation. Australia is the world's biggest coal exporter, and black coal is Australia's largest export, worth around $A13.5 billion annually. Dense medium cyclones process the vast majority of tonnes fed to Australian coal preparation plants, and hence play a critical economic role in coal production. This project aims at providing substantial design and operational improvements through the application of a novel combined continuum and ....Particle scale modelling of dense medium cyclones in coal preparation. Australia is the world's biggest coal exporter, and black coal is Australia's largest export, worth around $A13.5 billion annually. Dense medium cyclones process the vast majority of tonnes fed to Australian coal preparation plants, and hence play a critical economic role in coal production. This project aims at providing substantial design and operational improvements through the application of a novel combined continuum and discrete modelling method. Specifically, the improvements targeted relate to better process and product control, a decrease in unit energy consumption and improvements in productivity, which, together with the research training offered, will further enhance Australia's leading position in global coal industry.Read moreRead less
Microdynamic modelling and analysis of gas fluidization of particle mixtures. The project aims to develop a comprehensive understanding of the mechanisms governing the particle-fluid flow in gas fluidization of mixtures of particles of different sizes. This will be achieved through detailed analysis of the particle-particle and particle-fluid interactions on the basis of the microdynamic or particle scale results generated by the newly developed discrete simulation technique. The microscopic fin ....Microdynamic modelling and analysis of gas fluidization of particle mixtures. The project aims to develop a comprehensive understanding of the mechanisms governing the particle-fluid flow in gas fluidization of mixtures of particles of different sizes. This will be achieved through detailed analysis of the particle-particle and particle-fluid interactions on the basis of the microdynamic or particle scale results generated by the newly developed discrete simulation technique. The microscopic findings will be implemented in the macroscopic, continuum-based modelling and tested by comparing numerical and experimental results. It will significantly enhance the present capability of modelling particle-fluid flow in gas fluidization which is widely used in mineral/chemical industries.Read moreRead less