Development Of A Magnetic Resonance Imaging (MRI) Platform To Evaluate Neuroprotective And Regenerative Therapies In MS
Funder
National Health and Medical Research Council
Funding Amount
$116,667.00
Summary
Multiple Sclerosis (MS) involves inflammation and damage to nerve cells. New therapies are needed to minimize and reverse nerve cell damage. Currently, ways to judge the benefit of these therapies are primitive. We propose that assessing the benefits of these treatments in optic neuritis (inflammation of the eye nerve) is the way forward but first, we need to develop reliable tests to measure these treatments. This application proposes to use magnetic resonance imaging (MRI) for this purpose.
Cognitive Dysfunction In Multiple Sclerosis And Its Relationship To Mood Disturbance And Fatigue
Funder
National Health and Medical Research Council
Funding Amount
$57,342.00
Summary
This research aims to test a hypothesized model addressing the interplay between cognitive dysfunction, mood disturbance, and fatigue in people with multiple sclerosis as well as determine the associated impact on daily functioning and quality of life. The importance of background factors, disease factors and psychosocial factors in predicting cognitive dysfunction will also be investigated. Recommendations for new rehabilitation approaches will be developed in light of our findings.
The Role Of BMP Signalling During Chronic Demyelination And Myelin Repair
Funder
National Health and Medical Research Council
Funding Amount
$67,381.00
Summary
Multiple sclerosis (MS) is the most common neurodegenerative disease affecting young adults. It is a disease that kills myelin cells, which are important support cells for neurons and critical for neuronal function. This research investigates the role of a specific signaling pathway with respect to myelin cell production and repair with the ultimate aim of identifying regenerative therapeutics for MS.
Monomeric C-reactive Protein As Pathogenic Factor And Therapeutic Target In Athero-thrombotic Disease.
Funder
National Health and Medical Research Council
Funding Amount
$86,570.00
Summary
Vascular disease of the heart, brain and limbs affects many people in Australia and throughout the world. Current treatments assist in slowing the development and progression of established disease, but new developments are required. This project will investigate the role of C-reactive protein in vascular disease and evaluate its potential as a new therapeutic target in the future.