Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principl ....Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principles as macroscopic machines. Comparing the artificial motor with biological motors will provide insight into the workings of natural motors. This project should lead to molecular motors for nanobiotechnology.Read moreRead less
Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to a ....Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101569
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
A novel graphene-based optical sensing platform. Graphene has extraordinary electronic and optical properties as well as large specific surface area which afford great potential for sensor applications. This project will develop an innovative sensing platform to bring graphene related materials and devices a step closer to practical applications, particularly in biochemical sensors.
Understanding the properties of layered nanostructures using in-situ TEM. This project aims to support the practical applications of layered nanostructure-based devices and systems. The development of layered chalcogenide nanostructures is a global research focus due to their potential applications in the energy sector. However, their structure–property link is unclear due to the lack of direct correlation between their structure and properties. This project aims to establish the intrinsic struc ....Understanding the properties of layered nanostructures using in-situ TEM. This project aims to support the practical applications of layered nanostructure-based devices and systems. The development of layered chalcogenide nanostructures is a global research focus due to their potential applications in the energy sector. However, their structure–property link is unclear due to the lack of direct correlation between their structure and properties. This project aims to establish the intrinsic structure–property link by closely correlating the structure (and structural variations) and properties (and varied properties) simultaneously determined from individual nanostructures inside a transmission electron microscope. Expected project outcomes may advance the knowledge base, and provide guidelines for the development of nanostructure-based devices for their high-performance applications, especially in the energy sector.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100163
Funder
Australian Research Council
Funding Amount
$639,369.00
Summary
Nano-bioscience imaging facility. This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge imaging technologies. The project will consist of an ImageStreamX Imaging Flow Cytometer and a Coherent Anti-Stokes Raman Scattering Microscope. Together these will allow high throughput and label-free imaging of cell-nanomaterial interactions, which will underpin research by leading researchers as well as promoting collabora ....Nano-bioscience imaging facility. This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge imaging technologies. The project will consist of an ImageStreamX Imaging Flow Cytometer and a Coherent Anti-Stokes Raman Scattering Microscope. Together these will allow high throughput and label-free imaging of cell-nanomaterial interactions, which will underpin research by leading researchers as well as promoting collaborations between researchers in the physical and life sciences. This will provide significant benefits, such as the development of new materials for potential applications in nano-bioscience.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101452
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Silk-based conformal pressure sensing devices. This project aims to develop silk biomaterials-based biocompatible and conformal pressure sensing devices and systems for sustainable wearable electronics. Biocompatible conformal sensing interfaces and sensor arrays will be developed for real-time highly sensitive measurement of pressure, critical for accurate and comprehensive health monitoring and electronic skins. It is believed that the wearable products will provide comfort, utility and accura ....Silk-based conformal pressure sensing devices. This project aims to develop silk biomaterials-based biocompatible and conformal pressure sensing devices and systems for sustainable wearable electronics. Biocompatible conformal sensing interfaces and sensor arrays will be developed for real-time highly sensitive measurement of pressure, critical for accurate and comprehensive health monitoring and electronic skins. It is believed that the wearable products will provide comfort, utility and accurate physical information to end users, and improve the performance of personnel working in demanding environments, such as in defence forces, athletics and outfield industrial operations, by continuously monitoring physiological parameters.Read moreRead less
Multifunctional particles for biological applications. This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biolog ....Multifunctional particles for biological applications. This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biological barriers. This project will develop a platform for the assemble of particles with tailored properties which are expected to provide insights on particle-biological interactions for particle-based therapeutic delivery.Read moreRead less
Three dimensional nano-lithography: combined electron and ion beam fabrication. By adding one more dimension to a planar (hence two dimensional - 2D) lithography, it will become possible to structure and texture materials in three dimensions (3D) by combining electron beam lithography (2D) and ion beam milling (3D) with the highest precision of several nanometres. This will open new applications in photonics and sensing.
Discovery Early Career Researcher Award - Grant ID: DE160100796
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Superior Adsorption Capability of Nanosheets for Surface Enhanced Raman. This project aims to create nanotechnologies to sense traces of chemical and biological molecules. Surface adsorption is vital to many scientific and industrial fields, but the intrinsic adsorption property of two-dimensional nanomaterials is largely unknown. This project aims to examine the adsorption capability of nanosheets, such as boron nitride, and understand the thickness effect on their adsorption at the molecular s ....Superior Adsorption Capability of Nanosheets for Surface Enhanced Raman. This project aims to create nanotechnologies to sense traces of chemical and biological molecules. Surface adsorption is vital to many scientific and industrial fields, but the intrinsic adsorption property of two-dimensional nanomaterials is largely unknown. This project aims to examine the adsorption capability of nanosheets, such as boron nitride, and understand the thickness effect on their adsorption at the molecular scale. It also aims to demonstrate the use of these nanosheets as substrates in surface-enhanced Raman spectroscopy. Their adsorption capability and other unique properties could improve the sensitivity, efficiency and affordability of this technique in chemical and biological sensing for applications such as air, water and food safety; and pharmaceutical and cosmetic industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100121
Funder
Australian Research Council
Funding Amount
$270,000.00
Summary
An integrated system for characterisation of mechanical behaviour of bio- and nanomaterials at micro and nano scales in Queensland. Australia's material sciences will benefit from a new integrated system capable of microforce and nanomechanical testing of biomaterials, polymers and thin films, medical devices and electronics at the micro and nano scales. This facility will support ground-breaking research. It will help promote strategic collaboration and ensure the competitiveness of related and ....An integrated system for characterisation of mechanical behaviour of bio- and nanomaterials at micro and nano scales in Queensland. Australia's material sciences will benefit from a new integrated system capable of microforce and nanomechanical testing of biomaterials, polymers and thin films, medical devices and electronics at the micro and nano scales. This facility will support ground-breaking research. It will help promote strategic collaboration and ensure the competitiveness of related and emerging industries.Read moreRead less