Complex Multiscale Systems: Modeling, Analysis and Scientific Computation. This project aims to develop and implement a systematic approach, both analytic and computational, to extract compact, accurate, system level models of complex physical and engineering systems. The wide ranging methodology is to construct computationally efficient "wrappers" around fine scale, microscopic, detailed descriptions of dynamical systems (particle or molecular simulation, or partial differential equations or la ....Complex Multiscale Systems: Modeling, Analysis and Scientific Computation. This project aims to develop and implement a systematic approach, both analytic and computational, to extract compact, accurate, system level models of complex physical and engineering systems. The wide ranging methodology is to construct computationally efficient "wrappers" around fine scale, microscopic, detailed descriptions of dynamical systems (particle or molecular simulation, or partial differential equations or lattice equations). Comprehensively accounting for multiscale interactions between subgrid processes among macroscale variations ensures stability and accuracy. Based on dynamical systems theory and analysis, this approach is expected to empower systematic analysis and understanding for optimal macroscopic simulation for forthcoming exascale computing.Read moreRead less
Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Accurate modelling of large multiscale dynamical systems for engineering and scientific simulation and analysis. In current modelling the underlying microscopic mechanisms are known, but the closures to translate microscale knowledge to a system level macroscopic description are rarely available. The project's computational methodologies will circumvent this stumbling block to radically change the modelling, exploration and understanding of complex systems.
Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a vi ....Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a visually cluttered world, from insects to humans or autonomous vehicles.Read moreRead less
New bar-encoded polymer microbeads for multiplexed bioanalysis-a quick and high-throughput approach for complex disease diagnosis. Distinguishable new bar-encoded (element-encoded) polymer microbeads associated with a mass spectroscopy-flow cytometer detector provide a novel platform for highly multiplexed biological analysis. Such an approach can simultaneously identify many non-self-agents at low concentrations, which facilitates early-stage complex disease diagnosis.
Multiscale modelling of systems with complex microscale detail. This project aims to develop systematic mathematical and computational methods for the compact and accurate macroscale modelling of systems with microscopic irregular details. The methodology, justified with mathematical analysis and computation, uses small bursts of particle/agent simulations, partial differential equation (PDEs), or difference equations, to efficiently predict macroscale behaviour. This project’s mathematical meth ....Multiscale modelling of systems with complex microscale detail. This project aims to develop systematic mathematical and computational methods for the compact and accurate macroscale modelling of systems with microscopic irregular details. The methodology, justified with mathematical analysis and computation, uses small bursts of particle/agent simulations, partial differential equation (PDEs), or difference equations, to efficiently predict macroscale behaviour. This project’s mathematical methodology aims to efficiently and accurately extract and simulate the collective dynamics which emerge on macroscales, leading to improved prediction and understanding of the significant features of these complex systems at the scale relevant to engineers and scientists.Read moreRead less
Organically-Capped Copper Nanowires for Soft Electronic Skin Sensors. Soft skin-like electronics can enable applications that are impossible to achieve with today's rigid circuit board technologies. However, it is difficult to realise such future soft electronics with traditional materials and conventional manufacturing methodologies. This project aims to synthesise novel organically-capped copper nanowires as electronic inks (e-inks) for developing cost-effective, soft, stretchable conductor (e ....Organically-Capped Copper Nanowires for Soft Electronic Skin Sensors. Soft skin-like electronics can enable applications that are impossible to achieve with today's rigid circuit board technologies. However, it is difficult to realise such future soft electronics with traditional materials and conventional manufacturing methodologies. This project aims to synthesise novel organically-capped copper nanowires as electronic inks (e-inks) for developing cost-effective, soft, stretchable conductor (e-skin) sensors, which are wearable for monitoring blood pulses, body motions and hand gestures in real-time and in situ. This is expected to advance our knowledge in nanotechnology and generate patentable technologies in soft e-skin sensors, and to bring significant scientific and economic gains to Australia.Read moreRead less
Fuzzy modelling and design of complex networked systems. This project aims to develop analysis and synthesis approaches for non-linear networked control systems, including modelling, stability analysis and design problems. The non-linear effects and analysis of networked control systems have received considerable attention because of the universal existence of nonlinearities in practice. Network-based non-linear systems are widely used but face problems from non-linearities and networks. This pr ....Fuzzy modelling and design of complex networked systems. This project aims to develop analysis and synthesis approaches for non-linear networked control systems, including modelling, stability analysis and design problems. The non-linear effects and analysis of networked control systems have received considerable attention because of the universal existence of nonlinearities in practice. Network-based non-linear systems are widely used but face problems from non-linearities and networks. This project will establish a software-based nonlinear networked control system platform to test the presented algorithms and strengthen the scenarios in applications. This project is expected to increase Australian excellence in cyber-security and advanced manufacturing.Read moreRead less
Nanostructured Electrocatalysts for Clean Fuels Production. This project aims to develop single-component and hybrid transition-metal and metal-free electrocatalysts with controllable nanostructures to efficiently and selectively catalyse carbon dioxide reduction and hydrogen evolution reactions for clean fuels production including hydrogen and low-carbon organic molecules. By combining experimental and theoretical modelling, this project plans to reveal the origins, mechanism and pathway of the ....Nanostructured Electrocatalysts for Clean Fuels Production. This project aims to develop single-component and hybrid transition-metal and metal-free electrocatalysts with controllable nanostructures to efficiently and selectively catalyse carbon dioxide reduction and hydrogen evolution reactions for clean fuels production including hydrogen and low-carbon organic molecules. By combining experimental and theoretical modelling, this project plans to reveal the origins, mechanism and pathway of these reactions, and the effect of catalyst composition and morphology on their performance. The resulting nanostructured catalysts are of great importance for feasible clean fuel generation and carbon dioxide reduction.Read moreRead less
Surface Engineered Biomaterials to Control Inflammation. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Experimental evidence demonstrates that engineered surface nanotopography in combination with surface chemistry downregulates the expression of proinflammatory cytokines from primary macrophages. The significance of these findings is that it may be possible to engineer the nanotopography of a biomedica ....Surface Engineered Biomaterials to Control Inflammation. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Experimental evidence demonstrates that engineered surface nanotopography in combination with surface chemistry downregulates the expression of proinflammatory cytokines from primary macrophages. The significance of these findings is that it may be possible to engineer the nanotopography of a biomedical device surface in a manner which leads to a desired and predictable level of inflammation and subsequent foreign body reaction (FBR) medical implants and tissue engineering constructs.Read moreRead less