Emotional Behaviour in England, 1930-1980. My aim is produce a study of emotional behaviour in England. This will be a contribution to the expanding history of gender and of the self. The project will demonstrate the importance, in terms of insights into cultural change, of recovery of previous emotional standards. Additionally it will test the claims that have been made about governmentality in the twentieth century.
Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principl ....Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principles as macroscopic machines. Comparing the artificial motor with biological motors will provide insight into the workings of natural motors. This project should lead to molecular motors for nanobiotechnology.Read moreRead less
Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to a ....Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.Read moreRead less
System identification of microstructure in the brain using magnetic resonance. Magnetic Resonance Imaging technologies will be exploited to probe the microstructure of the brain, using powerful Bayesian optimisation techniques and innovative uses of magnetic resonance. The project will in particular develop non-invasive imaging methods to quantify iron content in the brain, important for research on dementia and Alzheimer's disease.
Stability of nanoscale structures at the surface of metallic glasses. This project aims to develop advanced electrodes and catalysts for batteries and hydrogen generation. These technologies are crucial components in the efficient use of alternative energy supplies. The outcome of this project will be an accurate computer modelling tool for predicting nanoporous structures of metallic glass generated by de-alloying, and for establishing the role of various factors in determining the stability of ....Stability of nanoscale structures at the surface of metallic glasses. This project aims to develop advanced electrodes and catalysts for batteries and hydrogen generation. These technologies are crucial components in the efficient use of alternative energy supplies. The outcome of this project will be an accurate computer modelling tool for predicting nanoporous structures of metallic glass generated by de-alloying, and for establishing the role of various factors in determining the stability of metallic glass nanostructures. This work will include fundamental insights into glass surfaces and dissolution.Read moreRead less
Understanding the properties of layered nanostructures using in-situ TEM. This project aims to support the practical applications of layered nanostructure-based devices and systems. The development of layered chalcogenide nanostructures is a global research focus due to their potential applications in the energy sector. However, their structure–property link is unclear due to the lack of direct correlation between their structure and properties. This project aims to establish the intrinsic struc ....Understanding the properties of layered nanostructures using in-situ TEM. This project aims to support the practical applications of layered nanostructure-based devices and systems. The development of layered chalcogenide nanostructures is a global research focus due to their potential applications in the energy sector. However, their structure–property link is unclear due to the lack of direct correlation between their structure and properties. This project aims to establish the intrinsic structure–property link by closely correlating the structure (and structural variations) and properties (and varied properties) simultaneously determined from individual nanostructures inside a transmission electron microscope. Expected project outcomes may advance the knowledge base, and provide guidelines for the development of nanostructure-based devices for their high-performance applications, especially in the energy sector.Read moreRead less
Strengthening urban slum upgrading and urban governance in cities in Southeast Asia. 1. Improve the approach to evaluating the impact of slum upgrading in building institutional capacity, and thereby, on the longer-term continuity of poverty reduction for poor communities. These lessons can be applied in impoverished settlements in developed and developing countries;
2. Enhance best practice in planning upgrading projects and design of governance frameworks. These lessons can be applied throu ....Strengthening urban slum upgrading and urban governance in cities in Southeast Asia. 1. Improve the approach to evaluating the impact of slum upgrading in building institutional capacity, and thereby, on the longer-term continuity of poverty reduction for poor communities. These lessons can be applied in impoverished settlements in developed and developing countries;
2. Enhance best practice in planning upgrading projects and design of governance frameworks. These lessons can be applied throughout Asia - a region to which Australia is closely linked;
3. Make a substantial contribution to scholarly literature on urban upgrading and governance;
4. Strengthen international linkages between Australian researchers and key scholars in the USA, Canada, Philippines, Vietnam and Indonesia.
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Soft Modes, Amorphous Defects and the Mechanical Properties of Metallic Glasses. Accounting for the material properties of glassy solids in terms of the atomic configurations and processes remains a profound challenge, largely due to the complexity and heterogeneity of amorphous structure. This project uses computer simulations to explore the proposition that localised soft vibrational modes in metallic glasses play a role analogous to that of crystal defects and can provide a valuable microscop ....Soft Modes, Amorphous Defects and the Mechanical Properties of Metallic Glasses. Accounting for the material properties of glassy solids in terms of the atomic configurations and processes remains a profound challenge, largely due to the complexity and heterogeneity of amorphous structure. This project uses computer simulations to explore the proposition that localised soft vibrational modes in metallic glasses play a role analogous to that of crystal defects and can provide a valuable microscopic account of the material properties and their dependence on composition and preparation. This research will lead to a significant improvement in our capacity to tune the properties of amorphous alloys by fabrication methods.Read moreRead less
Kinetics of Fast Crystal Growth in Inorganic Alloys and Molecular Liquids. The aim of this project is to identify the physical origins of fast crystal growth in three important classes of materials: metallic alloys, chalcogenide alloys and organic molecules. Fast crystal growth is crucial to the development of solid state memory based on phase change. In metallic glasses and many pharmaceuticals, fast growth is a problem, destabilising the desired glassy state. The anticipated outcomes of the pr ....Kinetics of Fast Crystal Growth in Inorganic Alloys and Molecular Liquids. The aim of this project is to identify the physical origins of fast crystal growth in three important classes of materials: metallic alloys, chalcogenide alloys and organic molecules. Fast crystal growth is crucial to the development of solid state memory based on phase change. In metallic glasses and many pharmaceuticals, fast growth is a problem, destabilising the desired glassy state. The anticipated outcomes of the project will include the capability to chemically manipulate the crystal growth rate to design new functional phase changes devices, to identify new types of glass forming materials and to replace the 80-year-old theory of crystal growth with one that accurately reflects the microscopic mechanisms of ordering at the growing interface.Read moreRead less
Multifunctional particles for biological applications. This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biolog ....Multifunctional particles for biological applications. This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biological barriers. This project will develop a platform for the assemble of particles with tailored properties which are expected to provide insights on particle-biological interactions for particle-based therapeutic delivery.Read moreRead less