Meta-microscopy of insect tissue: How nature grows bicontinuous nanosolids. Several butterfly species grow a complex nano-sculptured matrix whose chiral network structure confers remarkable optical properties, including jewel-like reflections. The formation process remains mysterious and a spectacular case of bottom-up self-assembly at far larger scales than accessible in the lab. The project aims to decipher this process, by (a) tomography of a species where arrested growth sites represent time ....Meta-microscopy of insect tissue: How nature grows bicontinuous nanosolids. Several butterfly species grow a complex nano-sculptured matrix whose chiral network structure confers remarkable optical properties, including jewel-like reflections. The formation process remains mysterious and a spectacular case of bottom-up self-assembly at far larger scales than accessible in the lab. The project aims to decipher this process, by (a) tomography of a species where arrested growth sites represent time-frozen snapshots of the development, and (b) by a combination of micron-resolved in-vivo microscopy of a developing butterfly wing with a growth model to infer nanometer-scale information. This insight will lead to blueprints for self-assembly strategies and shed light on function and form of inner-cellular membranes. Read moreRead less
Novel statistical methods for data with non-Euclidean geometric structure. This project aims to develop new flexible regression models and classification algorithms, along with robust and efficient inference methods, applicable to a wide range of non-Euclidean data types which arise in many fields of science, business and technology. There are serious flaws with currently available methods of analysis for non-Euclidean data. This project expects to transform such analyses by providing new quanti ....Novel statistical methods for data with non-Euclidean geometric structure. This project aims to develop new flexible regression models and classification algorithms, along with robust and efficient inference methods, applicable to a wide range of non-Euclidean data types which arise in many fields of science, business and technology. There are serious flaws with currently available methods of analysis for non-Euclidean data. This project expects to transform such analyses by providing new quantitative tools within a unifying framework. The anticipated project outcomes will be of mathematical interest and valuable in applications such as finance (predicting Australian stock returns); modelling electroencephalography data; Australian geochemical data, relating to sediments; and Australian X-ray tumour image data. Read moreRead less
Laser-free on-chip super-resolution microscopy. The project aims to develop a compact, cost-effective on-chip super-resolution microscope through an innovative combination of imaging algorithms, optics and integrated photonics. This project addresses limitations in imaging algorithms that increase laser system complexity and constrain imaging speed and applications, as well as nanostructure fabrication issues. Expected outcomes include the discovery of emitter self-interference microscopy, new k ....Laser-free on-chip super-resolution microscopy. The project aims to develop a compact, cost-effective on-chip super-resolution microscope through an innovative combination of imaging algorithms, optics and integrated photonics. This project addresses limitations in imaging algorithms that increase laser system complexity and constrain imaging speed and applications, as well as nanostructure fabrication issues. Expected outcomes include the discovery of emitter self-interference microscopy, new knowledge in imaging, photonics and biophysics, the world’s fastest super-resolution technology, compact on-chip nanoscopy that can be added to existing technology and proof of concept in three areas. Benefits are anticipated in commercialisation, improved photonics devices and usage in biophysics.Read moreRead less
Ultra-reliable and low-latency mission critical communications. This project aims to develop enabling technologies for ultra-reliable and low-latency communications. While the evolution of wireless communication technologies to date has focused on data rate improvement, very little is known on how to achieve ultra-reliability and almost-zero latency which is urgently required for mission critical applications such as smart manufacturing and intelligent vehicles. The outcomes of the project will ....Ultra-reliable and low-latency mission critical communications. This project aims to develop enabling technologies for ultra-reliable and low-latency communications. While the evolution of wireless communication technologies to date has focused on data rate improvement, very little is known on how to achieve ultra-reliability and almost-zero latency which is urgently required for mission critical applications such as smart manufacturing and intelligent vehicles. The outcomes of the project will be new analytical tools and practical guidelines for designing trusted communication platforms to realise these applications, with benefits ranging from improved safety in intelligent transportation systems to digital transformation of the manufacturing industry.Read moreRead less
Optical frequency conversion in nonlinear dielectric metasurfaces. This project aims to investigate the mixing of light colours in semiconductor nanocrystals arranged in an ultra-thin transparent film, called a nonlinear metasurface. Understanding of the resonant nonlinear interactions in such metasurfaces will allow for the up and down frequency conversion of light beams and images with efficiencies well beyond current capabilities. The outcomes of the project will form the basis for novel cost ....Optical frequency conversion in nonlinear dielectric metasurfaces. This project aims to investigate the mixing of light colours in semiconductor nanocrystals arranged in an ultra-thin transparent film, called a nonlinear metasurface. Understanding of the resonant nonlinear interactions in such metasurfaces will allow for the up and down frequency conversion of light beams and images with efficiencies well beyond current capabilities. The outcomes of the project will form the basis for novel cost-effective and compact devices for infrared imaging, and will also enable ultra-fast sources of quantum light with tailored spatial and spectral correlations. These will benefit important applications in defence and security, including night vision, security holograms, quantum cryptography and communications.Read moreRead less
Nanowire infrared avalanche photodetectors towards single photon detection. This project aims to demonstrate semiconductor nanowire based infrared avalanche photodetectors (APDs) with ultra-high sensitivity towards single photon detection. By employing the advantages of their unique one-dimensional nanoscale geometry, the nanowire APDs can be engineered to different device architectures to achieve performance superior to their conventional counterparts. It is expected that this project will mak ....Nanowire infrared avalanche photodetectors towards single photon detection. This project aims to demonstrate semiconductor nanowire based infrared avalanche photodetectors (APDs) with ultra-high sensitivity towards single photon detection. By employing the advantages of their unique one-dimensional nanoscale geometry, the nanowire APDs can be engineered to different device architectures to achieve performance superior to their conventional counterparts. It is expected that this project will make significant contributions to the development of next generation high performance, fast speed, small size and low cost infrared photodetector technology platform enabling numerous emerging fields in modern transportation, communication, quantum computation and information processing to revolutionise our life and society.Read moreRead less
Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovativ ....Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovative and broadly-applicable neuroscience methods and an understanding of receptors involved in plant growth and defense. Benefits of this project include an enhanced capacity to generate knowledge, multidisciplinary training opportunities and patentable synthetic biology technologies.Read moreRead less
Metaphotonics and metasurfaces for disruptive sensing technologies. This project aims to address a big challenge in nanophotonics by developing revolutionary methods for efficient chiral sensing of molecules without the need for spectrometry, frequency scanning, or moving mechanical parts, and to enhance chiroptical signals a hundredfold with the help of metasurface structures. Resonant metasurfaces are arrays of engineered dielectric nanoparticles with extraordinary characteristics, and they wo ....Metaphotonics and metasurfaces for disruptive sensing technologies. This project aims to address a big challenge in nanophotonics by developing revolutionary methods for efficient chiral sensing of molecules without the need for spectrometry, frequency scanning, or moving mechanical parts, and to enhance chiroptical signals a hundredfold with the help of metasurface structures. Resonant metasurfaces are arrays of engineered dielectric nanoparticles with extraordinary characteristics, and they would allow to overcome current limitations of chiral sensing analytical tools. Detecting chiral molecules in low concentrations is crucially important to many fields of biology, chemistry, and pharmacy, as well as to the food and cosmetics industries, constituting a market of tens of billions of dollars.Read moreRead less
Synthetic multi-dimensional integrated photonics. This project aims to develop and realise experimentally integrated circuits where light propagation mimics dynamics in arbitrarily complex imaginary photonic lattices. The project puts forward a universal and mass-fabrication compatible design concept of planar optical structures featuring unconventional synthetic multi-dimensional properties, which can also be reconfigured in real time. This underpins expected outcomes in optical detection with ....Synthetic multi-dimensional integrated photonics. This project aims to develop and realise experimentally integrated circuits where light propagation mimics dynamics in arbitrarily complex imaginary photonic lattices. The project puts forward a universal and mass-fabrication compatible design concept of planar optical structures featuring unconventional synthetic multi-dimensional properties, which can also be reconfigured in real time. This underpins expected outcomes in optical detection with fundamentally enhanced sensitivity and optical signal switching with ultra-low threshold. The benefits of such breakthrough improvements can have broad applications spanning from future optical communication networks to optical sensors for monitoring and health applications.Read moreRead less
Guiding principles and guardrails for genetic association studies. This project aims to investigate deep connections between genetic structure (population genetic processes, linkage disequilibrium and population structure) and the ability to statistically detect genetic variants responsible for variation in traits. The project expects to generate new knowledge in the areas of statistics, mathematics and biology through an innovative, multidisciplinary approach that synthesises and extends founda ....Guiding principles and guardrails for genetic association studies. This project aims to investigate deep connections between genetic structure (population genetic processes, linkage disequilibrium and population structure) and the ability to statistically detect genetic variants responsible for variation in traits. The project expects to generate new knowledge in the areas of statistics, mathematics and biology through an innovative, multidisciplinary approach that synthesises and extends foundational disciplinary results. Expected outcomes of this project include principles and methodology that underpin future genetic association studies by supplying a framework for interpreting results. This should provide significant benefits by reducing false conclusions and their associated costs.Read moreRead less