Discovery Early Career Researcher Award - Grant ID: DE130101350
Funder
Australian Research Council
Funding Amount
$373,038.00
Summary
A synthetic biology approach for mining the secondary metabolomes of fungal phytopathogens. Synthetic biology approaches will be employed to identify the secondary metabolites produced by the two important wheat pathogens, Stagonospora nodorum and Mycosphaerella graminicola. This will lead to the discovery of novel chemicals and facilitate our understanding of the roles of secondary metabolites in wheat diseases.
Field and quasi-field phenotyping for the quantitative characterisation of wheat yield under stress. The project aims to develop state-of-the-art monitoring and profiling capabilities for the quantitative assessment of plant growth performance in field and quasi-field environments under the abiotic stress conditions of drought and nutrient deficiency. This project involves the design and use of high resolution but low budget imaging stations to capture the growth of cereal plants in competitive ....Field and quasi-field phenotyping for the quantitative characterisation of wheat yield under stress. The project aims to develop state-of-the-art monitoring and profiling capabilities for the quantitative assessment of plant growth performance in field and quasi-field environments under the abiotic stress conditions of drought and nutrient deficiency. This project involves the design and use of high resolution but low budget imaging stations to capture the growth of cereal plants in competitive environments. Novel computer vision and image processing techniques will be applied to the image data to quantitatively characterise the success of genetic varieties to tolerate abiotic stress environments under actual field conditions.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100179
Funder
Australian Research Council
Funding Amount
$2,800,000.00
Summary
Controlling gene expression with synthetic RNA-binding proteins. Controlling gene expression with synthetic RNA-binding proteins. The growth and development of living organisms is largely determined by the genes they contain, but converting the genetic information into biological activity requires intermediary processes involving RNA and proteins that bind to and process RNA. This project aims to understand how the largest class of RNA-binding protein in plants recognise their target RNAs and ai ....Controlling gene expression with synthetic RNA-binding proteins. Controlling gene expression with synthetic RNA-binding proteins. The growth and development of living organisms is largely determined by the genes they contain, but converting the genetic information into biological activity requires intermediary processes involving RNA and proteins that bind to and process RNA. This project aims to understand how the largest class of RNA-binding protein in plants recognise their target RNAs and aims to develop custom-designed proteins for switching genes on or off. This technology will be used to create new hybrid cereal varieties and will also be valuable for applications in human health, such as the correction of genetic mutations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100024
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
Melbourne and Monash integrated proteomics facility. This project will provide two Victorian proteomic core facilities with cutting edge technology that will address a major gap in our mass spectrometry and protein interaction capabilitiy. These core facilities support a vast array of basic/applied research that depends on the characterisation of proteins and small molecules at a molecular level.
Decoding germination defects that threaten global wheat production. Wheat is a major commodity in Australia. Sprouting damage represents a major global threat to wheat production and food security. This project will explore the genetic and molecular mechanisms underpinning pre-harvest sprouting (PHS) and late-maturity amylase (LMA). This project will apply transcriptomics and proteomics to measure the expression of the biomolecules associated with PHS and LMA, generating fundamental knowledge of ....Decoding germination defects that threaten global wheat production. Wheat is a major commodity in Australia. Sprouting damage represents a major global threat to wheat production and food security. This project will explore the genetic and molecular mechanisms underpinning pre-harvest sprouting (PHS) and late-maturity amylase (LMA). This project will apply transcriptomics and proteomics to measure the expression of the biomolecules associated with PHS and LMA, generating fundamental knowledge of grain molecular physiology that addresses a significant knowledge gap. The project will deliver tools capable of differentiating these conditions, thereby minimising economic losses. A better understanding of the genetic basis of PHS and LMA will lay the foundation for advanced breeding aiming to eliminate these. Read moreRead less
Developing strong restorer-of-fertility genes for hybrid wheat breeding. Hybrid wheat varieties yield 10-15% more than conventional lines but a cost-effective system to produce hybrid seeds on a commercial scale is missing. This project aims to deliver such a system for use in hybrid wheat breeding programmes. The outcome will be ultimately higher wheat yield gains in Australia and worldwide. Higher and more stable yields will contribute to higher food security for the growing human population.
Australian Laureate Fellowships - Grant ID: FL200100057
Funder
Australian Research Council
Funding Amount
$3,311,491.00
Summary
Dynamic Proteins for Nutritious Future Crops. This project aims to understand the processes and genes that regulate synthesis and degradation of proteins in wheat and barley plants. This project will develop methodologies and a new field of research for optimising protein stability in crops. Its significance lies in defining new ways to control protein abundance to increase crop performance and quality and increase the value of recombinant proteins for biotech industries. Expected outcomes will ....Dynamic Proteins for Nutritious Future Crops. This project aims to understand the processes and genes that regulate synthesis and degradation of proteins in wheat and barley plants. This project will develop methodologies and a new field of research for optimising protein stability in crops. Its significance lies in defining new ways to control protein abundance to increase crop performance and quality and increase the value of recombinant proteins for biotech industries. Expected outcomes will enable the protein abundance in plant cells to be designed and control selective protein degradation in plants for the first time. Benefits will include building biotechnology capacity in WA, brokering new collaborations and providing an ideal training environment for students and postdocs.Read moreRead less
ARC Centre of Excellence in Plant Energy Biology. We propose a novel approach to improve sustainable yield by optimising the overall efficiency of energy capture, conversion and use by plants. Efficiency gains in metabolism, transport, and development will be more effective than optimising single nutrient inputs or product outputs. Improving multiple parameters simultaneously is a necessary solution to the increasing demand for more crop yield from finite land, water, and nutrient resources. Unp ....ARC Centre of Excellence in Plant Energy Biology. We propose a novel approach to improve sustainable yield by optimising the overall efficiency of energy capture, conversion and use by plants. Efficiency gains in metabolism, transport, and development will be more effective than optimising single nutrient inputs or product outputs. Improving multiple parameters simultaneously is a necessary solution to the increasing demand for more crop yield from finite land, water, and nutrient resources. Unpredictable environmental challenges adversely affect plant growth and further perturb plant energy balance, limiting yield. The epigenetic controls, gene variants and signals discovered will provide a new basis for sustainable productivity of crops and will future-proof plants in changing climates.Read moreRead less
Unlocking secrets of fertility restoration for hybrid breeding in crops. Hybrid varieties give higher and more stable yields than conventional lines, but a cost-effective system to make hybrid seed on a commercial scale is still missing for economically important crops like wheat or barley. By elucidating the mode of action of a new type of restorer gene plus exploiting ancient or exotic wheat and barley collections this project will reveal aspects of largely understudied mechanisms underlying f ....Unlocking secrets of fertility restoration for hybrid breeding in crops. Hybrid varieties give higher and more stable yields than conventional lines, but a cost-effective system to make hybrid seed on a commercial scale is still missing for economically important crops like wheat or barley. By elucidating the mode of action of a new type of restorer gene plus exploiting ancient or exotic wheat and barley collections this project will reveal aspects of largely understudied mechanisms underlying fertility restoration in wheat and barley. The expected outcomes of the proposed research have the potential to deliver new tools for hybrid seed production programs in wheat and barley. Higher and more stable yields from hybrids will ensure food security in the face of an uncertain climate and growing human population.Read moreRead less
Biosynthesis and functions of two phytotoxins in Septoria nodorum blotch. This project aims to investigate how a fungal plant pathogen makes and uses small bioactive molecules to facilitate infection. It will characterise the function of the genes and enzymes involved in the biosynthesis of a light-activated phytotoxic molecule and a potential anti-plant defence molecule found in the pathogenic wheat fungus Parastagonospora nodorum, and investigate their contribution to disease development. Expe ....Biosynthesis and functions of two phytotoxins in Septoria nodorum blotch. This project aims to investigate how a fungal plant pathogen makes and uses small bioactive molecules to facilitate infection. It will characterise the function of the genes and enzymes involved in the biosynthesis of a light-activated phytotoxic molecule and a potential anti-plant defence molecule found in the pathogenic wheat fungus Parastagonospora nodorum, and investigate their contribution to disease development. Expected outcomes include better understanding of plant-microbe interactions, disease management strategies, technologies for identifying biosynthetic pathways in other fungi, and enzyme technology for synthesising molecules. This could lead to new herbicides, biopesticides and drugs.Read moreRead less