Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100114
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as ....High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as well as validation of next generation sequencing data. The information generated is crucial to advancing knowledge in important research fields including infection and immunity, regenerative medicine, immune responses, biomarker discovery, drug discovery, biotechnology and agriculture.Read moreRead less
Characterisation of tumour variants of Devil Facial Tumour Disease. This project will take a new approach to cancer research by studying the evolution of Devil Facial Tumour Disease. The results will directly contribute to the conservation management of the Tasmanian devil, as well as generating new information on tumour growth, metastasis and emergence of resistance.
Evolution and function of mammalian sex chromosomes. Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understandin ....Evolution and function of mammalian sex chromosomes. Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understanding of mammalian reproduction. The knowledge gained will have application in captive breeding and conservation of these extraordinary Australian mammals. The project also provides opportunity to train research students in cutting edge molecular biology and informatics.Read moreRead less
Spatio-temporal activation of genes in cells and mice. This project aims to develop novel genetic methods and instrumentation for the local, rapid and reversible activation of genes in cells and mice. This project expects to generate highly innovative light- and sound-based technologies that will permit to study living systems on the gene-level with unprecedented precision. Expected outcomes include new research and technology capacity to broadly address fundamental biological questions and to c ....Spatio-temporal activation of genes in cells and mice. This project aims to develop novel genetic methods and instrumentation for the local, rapid and reversible activation of genes in cells and mice. This project expects to generate highly innovative light- and sound-based technologies that will permit to study living systems on the gene-level with unprecedented precision. Expected outcomes include new research and technology capacity to broadly address fundamental biological questions and to create new applied processes. This project intends to provide significant benefits, such as enhanced knowledge generation, multidisciplinary training opportunities and patentable technologies.Read moreRead less
Uncovering vertebrate lifespan biodiversity with whole genome sequencing. This project aims to integrate existing data on the genetic mechanisms of lifespan evolution in model systems with a novel combination of whole genome sequencing and comparative phylogenomics to reveal the common genomic signatures of lifespan evolution in vertebrates. Expected outcomes include a perspective on the evolution of lifespan, a topic of major health interest for Australia and the rest of the developed world. Th ....Uncovering vertebrate lifespan biodiversity with whole genome sequencing. This project aims to integrate existing data on the genetic mechanisms of lifespan evolution in model systems with a novel combination of whole genome sequencing and comparative phylogenomics to reveal the common genomic signatures of lifespan evolution in vertebrates. Expected outcomes include a perspective on the evolution of lifespan, a topic of major health interest for Australia and the rest of the developed world. This will provide significant benefits, such as long-term implications for aging research, with possible business applications. It will also increase Australia’s visibility and competitiveness in the developing field of bioinformatics.Read moreRead less
3'UTR switching in eukaryotic cells. The project aims to uncover conserved features fundamental to the mechanism and function of post-transcriptional gene-expression control. RNA systems interface the executive functions of DNA and the worker functions of proteins. mRNA often dictates the level, timing and location of protein synthesis. This project will use RNA-sequencing and bespoke bioinformatics to probe global RNA-dynamics. Mixing yeast-genetics with RNA-technologies, it focuses on 3’ untra ....3'UTR switching in eukaryotic cells. The project aims to uncover conserved features fundamental to the mechanism and function of post-transcriptional gene-expression control. RNA systems interface the executive functions of DNA and the worker functions of proteins. mRNA often dictates the level, timing and location of protein synthesis. This project will use RNA-sequencing and bespoke bioinformatics to probe global RNA-dynamics. Mixing yeast-genetics with RNA-technologies, it focuses on 3’ untranslated region (UTR) dynamics in eukaryotic cell biology. This project expects to significantly advance the understanding of eukaryotic gene function and gene regulation, critical in an age of personalised genomic medicine.Read moreRead less
From the pouch to the grave: age and sex related changes in immunity in the Tasmanian devil. Tasmanian devils face extinction in the wild due to the emergence of a contagious cancer: Devil Facial Tumour Disease (DFTD). A comprehensive understanding of the devil immune system is necessary to better understand the disease and develop a vaccine against it. This project will characterise immune responses of healthy devils throughout life, from the pouch, to onset of puberty, to old age. This project ....From the pouch to the grave: age and sex related changes in immunity in the Tasmanian devil. Tasmanian devils face extinction in the wild due to the emergence of a contagious cancer: Devil Facial Tumour Disease (DFTD). A comprehensive understanding of the devil immune system is necessary to better understand the disease and develop a vaccine against it. This project will characterise immune responses of healthy devils throughout life, from the pouch, to onset of puberty, to old age. This project will then compare these responses in DFTD-affected devils to determine why DFTD affects older animals first and does not affect sexually-immature devils. Additional outcomes will include the development of novel antibiotics against human and animal diseases and an atlas of devil development using the latest imaging technologies.Read moreRead less
Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to disco ....Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to discover epigenetic and genomic markers in skeletal muscle predictive of exercise adaptations. This will contribute to the development and future delivery of targeted and personalised exercise programs for the general population. This has important implications for improving health in the Australian population.Read moreRead less
Genetic regulation of developmental competence: molecular mechanisms that establish a competent state. Development is a key biological process for multicellular life. This project will study development using a simple, established experimental organism, a fungus, as a model for development in other organisms, including humans. Moreover, fungi directly impact on life at many levels and understanding their biology has direct benefits for society.
Can exercise slow down the epigenetic ageing clock? The aged population accounts for a significant amount of Australia’s health budget. This project aims to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. This project aims to use innovative epigenetic analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This is expected to lead to a better understanding of how humans re ....Can exercise slow down the epigenetic ageing clock? The aged population accounts for a significant amount of Australia’s health budget. This project aims to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. This project aims to use innovative epigenetic analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This is expected to lead to a better understanding of how humans respond to changing environments during their lifetime, and will underpin the development of evidence-based personalised health interventions to keep Australians healthier for longer.
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