Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineerin ....Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineering.Read moreRead less
Fleshing out the fossil record: using organically preserved soft tissues and bone to explore the evolution of unique vertebrate characters. This study integrates developmental, molecular and morphological data in both fossil and living species to provide insights into the evolutionary mechanisms which formed the musculo/skeletal system. Uncovering these evolutionary pathways has the potential to describe mechanisms common to all vertebrate and informs us about our own evolution.
Understanding and Addressing Everyday Sexisms in Australian Universities. This project aims to improve the ways in which gender-based discrimination is understood and addressed in Australian universities by employing a situated, intersectional, and creative approach to researching everyday sexisms. This project expects to use an innovative approach to generate new knowledge about everyday sexisms at the individual level and across disciplinary and university contexts. Expected outcomes include n ....Understanding and Addressing Everyday Sexisms in Australian Universities. This project aims to improve the ways in which gender-based discrimination is understood and addressed in Australian universities by employing a situated, intersectional, and creative approach to researching everyday sexisms. This project expects to use an innovative approach to generate new knowledge about everyday sexisms at the individual level and across disciplinary and university contexts. Expected outcomes include new gender equity practices that will assist universities to refine current programs, strategies, and policies capable of eliminating gender-based discrimination. This should provide significant benefits for Australian society, including women and gender diverse people working in universities.
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Interaction between consolidation and lubrication of biological joints. This project aims to develop a computational model to be used in conjunction with experimental studies to understand complex lubrication systems in biological joints. Nature has equipped biological joints with a remarkable ability to achieve ultralow friction even at relatively high contact force, however the mechanisms used remain uncertain. This project intends to provide a deeper, fundamental understanding of the friction ....Interaction between consolidation and lubrication of biological joints. This project aims to develop a computational model to be used in conjunction with experimental studies to understand complex lubrication systems in biological joints. Nature has equipped biological joints with a remarkable ability to achieve ultralow friction even at relatively high contact force, however the mechanisms used remain uncertain. This project intends to provide a deeper, fundamental understanding of the friction and contact mechanisms occurring in biological joints. The project outcomes could lead to bioinspired innovation in future engineering design and advancements in materials science that have the potential to significantly benefit Australian society.Read moreRead less
Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lip ....Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lipid biology at the cellular and sub-cellular level across a wide range of in vitro and in vivo models. The outcomes of this project should provide significant knowledge to tackle modern societal challenges in healthy ageing, brain pathologies and neurodegenerative diseases.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less
School autonomy and parent engagement in disadvantaged communities. This project aims to examine public secondary schools’ engagements with parents in disadvantaged communities. Through policy analysis and case studies, the project seeks to advance knowledge about how school autonomy reforms are potentially reshaping meanings and practices associated with public schooling. Expected outcomes include enhanced knowledge about the shifting nature of schooling reform in Australia and insights into ev ....School autonomy and parent engagement in disadvantaged communities. This project aims to examine public secondary schools’ engagements with parents in disadvantaged communities. Through policy analysis and case studies, the project seeks to advance knowledge about how school autonomy reforms are potentially reshaping meanings and practices associated with public schooling. Expected outcomes include enhanced knowledge about the shifting nature of schooling reform in Australia and insights into evolving relationships between governments and citizens in public service delivery. Intended benefits include insights to inform future policy design and implementation at school and system levels.Read moreRead less
“Beacons in the Night” unveiling how galaxies light up dark matter. How dark matter influences the formation and evolution of galaxies is to this day an outstanding question in astrophysics. To answer it, world-class facilities and a unique combination of observations and theory are required. This DP team, a world-class team of observers and theorists, will tackle this question by leveraging on two multi-million dollar projects: the MAGPI galaxy survey and the hydrodynamical simulations suite EA ....“Beacons in the Night” unveiling how galaxies light up dark matter. How dark matter influences the formation and evolution of galaxies is to this day an outstanding question in astrophysics. To answer it, world-class facilities and a unique combination of observations and theory are required. This DP team, a world-class team of observers and theorists, will tackle this question by leveraging on two multi-million dollar projects: the MAGPI galaxy survey and the hydrodynamical simulations suite EAGLE-XL. MAGPI will deliver exquisite kinematics for hundreds of galaxies in the middle ages of the Universe, providing a view to the effect of dark matter on galaxies at this critical time, while EAGLE-XL represents the technological frontier in simulations and provides the best interpretative framework for MAGPI.Read moreRead less
Intergenerational Prediction of Social and Early Emotional Development. This project aims to investigate multi-generational influences on child psychosocial development. It plans to take advantage of a not-to-be-repeated opportunity to follow offspring born to one of Australia’s oldest longitudinal studies of social and emotional development. The Australian Temperament Project has followed around 2000 parents and offspring across 30 years from birth in 1983. Third-generation babies have been fol ....Intergenerational Prediction of Social and Early Emotional Development. This project aims to investigate multi-generational influences on child psychosocial development. It plans to take advantage of a not-to-be-repeated opportunity to follow offspring born to one of Australia’s oldest longitudinal studies of social and emotional development. The Australian Temperament Project has followed around 2000 parents and offspring across 30 years from birth in 1983. Third-generation babies have been followed across the peak period of first births to females. This project plans to continue recruitment across the peak period of first births for males in 2016–18. This would create one of the most extensive and well-powered three-generation resources worldwide, yielding unique data on intergenerational pathways through mother and father lines. It expects to inform targeting of interventions and psychosocial resources to promote wellbeing within and across generations.Read moreRead less