Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability t ....Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability through the convergence of expertise and innovation in analytical chemistry, materials science and cellular biology, ultilising the latest technology and understanding of 3D micro/electrofluidics, to enable the study and stimulation of advanced biological models, sustained within precisely controlled 3D micro-environments.Read moreRead less
The Inception of Criminal Deportation in Colonial Australia . This project aims to undertake the first comprehensive study of criminal deportation in colonial Australia. Expected outcomes include new knowledge on freely arrived colonists who were tried, sentenced to transportation, and criminally deported within the Australian colonies. The project spans the disciplines of history and criminology, developing a new methodological framework that aims to facilitate important insights on the societa ....The Inception of Criminal Deportation in Colonial Australia . This project aims to undertake the first comprehensive study of criminal deportation in colonial Australia. Expected outcomes include new knowledge on freely arrived colonists who were tried, sentenced to transportation, and criminally deported within the Australian colonies. The project spans the disciplines of history and criminology, developing a new methodological framework that aims to facilitate important insights on the societal attitudes, systems, and circumstances that led to criminal deportation. This should provide significant benefits by articulating the unexplored deep history of Australian criminal deportation practices. The project also aims to preserve fragile colonial documents foundational to the nation’s history.Read moreRead less
Understanding the mechanisms underpinning complex sociality. This project aims to investigate the mechanisms underlying the formation of complex social systems in vertebrates. Our understanding of these mechanisms is strongly biased towards a few model systems. We have identified a novel Australian model system with a wide range of sociality for this purpose. This project expects to generate new knowledge on how the social environment interacts with the brain during social organisation. Expected ....Understanding the mechanisms underpinning complex sociality. This project aims to investigate the mechanisms underlying the formation of complex social systems in vertebrates. Our understanding of these mechanisms is strongly biased towards a few model systems. We have identified a novel Australian model system with a wide range of sociality for this purpose. This project expects to generate new knowledge on how the social environment interacts with the brain during social organisation. Expected outcomes include the refinement of social theory and capacity building via international collaboration and postgraduate training. This work will provide significant benefits by increasing our understanding of how the brain and social environment interact to moderate aggression and enhance social associations.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100201
Funder
Australian Research Council
Funding Amount
$460,806.00
Summary
Learning how we learn: linking inhibitory brain circuits to motor learning. Understanding the relationship between brain activity and human behaviour is a fundamental question in neuroscience. This project aims to contribute to this question by using cutting-edge brain stimulation techniques to demonstrate causal relationships between inhibitory brain circuit activity and motor learning. This project expects to generate fundamental knowledge about the relationship between the brain and behaviour ....Learning how we learn: linking inhibitory brain circuits to motor learning. Understanding the relationship between brain activity and human behaviour is a fundamental question in neuroscience. This project aims to contribute to this question by using cutting-edge brain stimulation techniques to demonstrate causal relationships between inhibitory brain circuit activity and motor learning. This project expects to generate fundamental knowledge about the relationship between the brain and behaviours. Eventually, this may contribute to the development of optimised training protocols in healthy populations such as school children, recreational and elite athletes, medical and military personnel, and ageing adults, as well as the development of brain stimulation interventions to improve motor learning.Read moreRead less
Tools for manipulating neuronal activity for behavioural studies. This project aims to develop optogenetic tools neuroscientists can use to better understand brain circuitry and the functional effects of specific neurons on behaviour. Linking the activity of individual neurons in the brain to specific behaviours is a major challenge in neuroscience. Optogenetics achieve this by using light to control the activity of neurons. This has advanced understanding of behaviour and neurocircuitry. This p ....Tools for manipulating neuronal activity for behavioural studies. This project aims to develop optogenetic tools neuroscientists can use to better understand brain circuitry and the functional effects of specific neurons on behaviour. Linking the activity of individual neurons in the brain to specific behaviours is a major challenge in neuroscience. Optogenetics achieve this by using light to control the activity of neurons. This has advanced understanding of behaviour and neurocircuitry. This project is expected to increase understanding of brain function at the cellular and system levels, and advance Australia’s multidisciplinary research capacity in neuroscience, cognitive sciences and nanobiotechnology to ultimately treat neurological disorders.Read moreRead less
Creating new stochastic models to understand the evolution of gene families. This project aims to extend stochastic modelling techniques in order to develop mathematically rigorous and biologically relevant models for the evolution of gene families. The project expects to model evolutionary processes such as gene retention, duplication and loss, and the generation of new gene functions. The duplication and subsequent re-purposing of genes is thought to be a key mechanism for generating evolution ....Creating new stochastic models to understand the evolution of gene families. This project aims to extend stochastic modelling techniques in order to develop mathematically rigorous and biologically relevant models for the evolution of gene families. The project expects to model evolutionary processes such as gene retention, duplication and loss, and the generation of new gene functions. The duplication and subsequent re-purposing of genes is thought to be a key mechanism for generating evolutionary novelty. By applying these models to genome data, the project expects to be able to quantify the importance of these different evolutionary mechanisms. The project will strengthen collaborative links between researchers in stochastic modelling and molecular evolutionary biology.Read moreRead less
A Buddhist Debate and Its Contemporary Relevance. The aim of this project is to engage with one of the central debates in Tibetan philosophy concerning truth, realism and epistemic justification. It plans to explore the implications of this debate for subsequent Tibetan thought and for contemporary Western analytic philosophy. The project plans to analyse previously unstudied texts and demonstrate the fecundity of a traditional method of collaborative cross-cultural philosophy today in which Tib ....A Buddhist Debate and Its Contemporary Relevance. The aim of this project is to engage with one of the central debates in Tibetan philosophy concerning truth, realism and epistemic justification. It plans to explore the implications of this debate for subsequent Tibetan thought and for contemporary Western analytic philosophy. The project plans to analyse previously unstudied texts and demonstrate the fecundity of a traditional method of collaborative cross-cultural philosophy today in which Tibetan and Western scholars work together to develop joint analyses. It may also demonstrate that the metaphysical and epistemological ideas and arguments developed in these debates can contribute to Western philosophy.Read moreRead less
Dust to the ocean: Does it really increase productivity? This project aims to investigate the relationship between dust deposition and marine productivity. This project will quantify dust deposition to the ocean and its chemical and ecological impact by using new geochemical techniques and novel approaches with autonomous ocean sensors. Expected outcomes of this project include improved estimates of dust deposition to the ocean and the development of globally-applicable methods for quantifying t ....Dust to the ocean: Does it really increase productivity? This project aims to investigate the relationship between dust deposition and marine productivity. This project will quantify dust deposition to the ocean and its chemical and ecological impact by using new geochemical techniques and novel approaches with autonomous ocean sensors. Expected outcomes of this project include improved estimates of dust deposition to the ocean and the development of globally-applicable methods for quantifying the link between dust and biology using profiling floats. This should provide significant benefits such as improved dust models used to predict future changes in nutrient deposition, with implications for predicting future ocean fish production and carbon uptake.Read moreRead less
ARC Centre of Excellence for Plant Success in Nature and Agriculture. The ARC CoE for Plant Success in Nature and Agriculture will discover the adaptive strategies underpinning productivity and resilience in diverse plants and deepen knowledge of the genetic and physiological networks driving key traits. Using novel quantitative and computational approaches, the Centre will link gene networks with traits across biological levels, giving breeders an unparalleled predictive capacity. The Centre wi ....ARC Centre of Excellence for Plant Success in Nature and Agriculture. The ARC CoE for Plant Success in Nature and Agriculture will discover the adaptive strategies underpinning productivity and resilience in diverse plants and deepen knowledge of the genetic and physiological networks driving key traits. Using novel quantitative and computational approaches, the Centre will link gene networks with traits across biological levels, giving breeders an unparalleled predictive capacity. The Centre will accelerate technologies to transfer successful networks into crops and build legal frameworks to secure this knowledge. With a uniquely multidisciplinary team, the Centre will deliver new strategies to address the problems of food security and climate change, establishing Australia as a global leader in these areas.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less