Bodies in space. By investigating how a change in shape of the human body can produce a change in spatial orientation, the project will bring a fundamental advance of knowledge in the intersection of applied mathematics, sports science and mechanical engineering. These knowledge advances will lead to a novel theory regarding the control of the aerial dynamics of athletes, specifically springboard and platform divers. When applied in collaboration with world class Australian athletes, this theory ....Bodies in space. By investigating how a change in shape of the human body can produce a change in spatial orientation, the project will bring a fundamental advance of knowledge in the intersection of applied mathematics, sports science and mechanical engineering. These knowledge advances will lead to a novel theory regarding the control of the aerial dynamics of athletes, specifically springboard and platform divers. When applied in collaboration with world class Australian athletes, this theory will result in innovative platform and springboard diving techniques and improved performance. The reach of new insights generated by this work extends to many other fields, including robotics, spacecraft dynamics and nano technology.Read moreRead less
Investigating a novel, physical adjuvant for improving immune responses of vaccines. This project will explore a new way to significantly improve vaccine immune responses: with practical devices that apply pressure on the skin - for the body to create its own, localised adjuvant. This is novel - completely different to today's adjuvants, which are chemicals put into our bodies.
A Nano-platform for affordable and ultra-sensitive bio-marker detection. This project aims to develop a next-generation nano-platform and lateral flow assays (LFA) device for ultra-sensitive detection of biomarkers. LFA’s are used for the rapid detection of biomarkers; however, their sensitivity is relatively low. The preparation of innovative porous silica nanoparticles with uniform particle size and controllable structures (pore size, pore structure, internal surface functionality and density ....A Nano-platform for affordable and ultra-sensitive bio-marker detection. This project aims to develop a next-generation nano-platform and lateral flow assays (LFA) device for ultra-sensitive detection of biomarkers. LFA’s are used for the rapid detection of biomarkers; however, their sensitivity is relatively low. The preparation of innovative porous silica nanoparticles with uniform particle size and controllable structures (pore size, pore structure, internal surface functionality and density) will enable higher loading of quantum dots and enhanced detection sensitivity. Improving the detection sensitivity of the inexpensive and disposable LFA diagnostic technology will open up new applications for rapid and accurate biomarker detection. The resulting technology will advance Australian industrial capability and competiveness in the global lateral flow assays market, which is estimated to be valued at US$ 6.78 billion by 2020.Read moreRead less
Development of a market relevant DNA nano-vaccine platform. DNA vaccine technology can potentially provide a rapid response to existing or new pathogens, but its market success has been limited. By addressing key scientific and technical challenges, this project aims to develop a new and cost-effective DNA nanovaccine platform using a multiscale engineering approach. It is anticipated that novel nanoparticles for DNA delivery and an end-user-driven DNA vaccine technology with enhanced immunogeni ....Development of a market relevant DNA nano-vaccine platform. DNA vaccine technology can potentially provide a rapid response to existing or new pathogens, but its market success has been limited. By addressing key scientific and technical challenges, this project aims to develop a new and cost-effective DNA nanovaccine platform using a multiscale engineering approach. It is anticipated that novel nanoparticles for DNA delivery and an end-user-driven DNA vaccine technology with enhanced immunogenicity, stability and safety will be generated. Expected outcomes include new knowledge in nanomaterial science and a market ready technology platform, improving Australia’s capabilities in nanobiotechnology and vaccine development, as well as delivering a new value-added product for the Industry Partner. Read moreRead less
Deadly Futures:Enabling Indigenous Children’s Literacy, Numeracy, Wellbeing. This project aims to test the effectiveness of new literacy, numeracy and wellbeing interventions using powerful interdisciplinary approaches. The project expects to generate new knowledge about enabling Indigenous students to have deadly futures by enhancing literacy, numeracy and wellbeing, capitalising on research-derived interventions and the wisdom of Indigenous communities. Expected outcomes include salient interv ....Deadly Futures:Enabling Indigenous Children’s Literacy, Numeracy, Wellbeing. This project aims to test the effectiveness of new literacy, numeracy and wellbeing interventions using powerful interdisciplinary approaches. The project expects to generate new knowledge about enabling Indigenous students to have deadly futures by enhancing literacy, numeracy and wellbeing, capitalising on research-derived interventions and the wisdom of Indigenous communities. Expected outcomes include salient intervention and advances in Indigenous education. Benefits encompass identifying effective intervention and drivers that enhance Indigenous students’ literacy, numeracy, wellbeing, and adaptive motivation, and working effectively in genuine partnership with Indigenous community to address a community-identified need.Read moreRead less
Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by ....Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by implementing innovative approaches.
Expected Outcomes: Expected outcomes include significant new knowledge and a new multi-disciplinary platform for measuring peptide absorption.
Benefits: This should provide significant benefits by informing the future design of peptides for supplements, therapeutics and carriers. Read moreRead less
Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation o ....Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation of nanomaterials with antibodies. This project has the potential to rapidly improve the ligation process between synthetic nanomaterials and biologics, leading to more efficient synthesis of targeted diagnostics. This would provide a significant commercial advantage for any nanomaterials developed for the field, and specifically for this project, expedite translation of MIL38.Read moreRead less
Next generation lasers for short-reach optical fibre communication. This project aims to develop next-generation laser systems for multimode fibre-optic communication systems, by leveraging recently developed techniques for measuring and controlling the spatial properties of light. These techniques will provide new insights into the physics of the lasers themselves, as well as overcoming fundamental limitations which have traditionally hindered their operation at high speed. The expected outcome ....Next generation lasers for short-reach optical fibre communication. This project aims to develop next-generation laser systems for multimode fibre-optic communication systems, by leveraging recently developed techniques for measuring and controlling the spatial properties of light. These techniques will provide new insights into the physics of the lasers themselves, as well as overcoming fundamental limitations which have traditionally hindered their operation at high speed. The expected outcome of this project is the inclusion of these techniques in the development and operation of future generations of fibre communication systems. Creating new classes of laser systems, which can scale to large bit rates, will enable the growth in this area to be sustained into the future.Read moreRead less
Developing next-generation mass spectrometry imaging with isomer resolution. Mass spectrometry imaging (MSI) is a rapidly emerging technology for mapping molecular distributions within biological samples. This project will bring together market-leading MSI instrumentation from the industry partner Waters Corporation with unique technologies developed at QUT and UOW to develop an integrated MSI-platform capable of achieving high mass- and spatial-resolution, as well as discrimination of lipid iso ....Developing next-generation mass spectrometry imaging with isomer resolution. Mass spectrometry imaging (MSI) is a rapidly emerging technology for mapping molecular distributions within biological samples. This project will bring together market-leading MSI instrumentation from the industry partner Waters Corporation with unique technologies developed at QUT and UOW to develop an integrated MSI-platform capable of achieving high mass- and spatial-resolution, as well as discrimination of lipid isomers. Resolution of lipid isomers using this instrumentation will afford researchers a first glimpse of isomer-resolved images that will be used to visualise tissue-specific changes resulting from underlying chemical, physical or metabolic processes; changes that are currently invisible to contemporary imaging technologies.Read moreRead less
The worlds next door: terrestrial exoplanets with the TOLIMAN space mission. This project aims to to explore our nearest neighbour star system, Alpha Centauri, for the first time probing for exoplanets with physical characteristics that resemble those of Earth. The finding of any such world, with the potential to support a biosphere like our own and lying only 4 light-years away, would profoundly alter our view of our place in the universe. The primary outcome of this project will be the design, ....The worlds next door: terrestrial exoplanets with the TOLIMAN space mission. This project aims to to explore our nearest neighbour star system, Alpha Centauri, for the first time probing for exoplanets with physical characteristics that resemble those of Earth. The finding of any such world, with the potential to support a biosphere like our own and lying only 4 light-years away, would profoundly alter our view of our place in the universe. The primary outcome of this project will be the design, construction, launch and operation of a novel and innovative space telescope: the TOLIMAN mission. This profoundly benefits the Australian space and university sectors, partnering them with international agencies to deliver marquee science with global impact: the search for our first stepping stone to interstellar space.Read moreRead less