Emotional Behaviour in England, 1930-1980. My aim is produce a study of emotional behaviour in England. This will be a contribution to the expanding history of gender and of the self. The project will demonstrate the importance, in terms of insights into cultural change, of recovery of previous emotional standards. Additionally it will test the claims that have been made about governmentality in the twentieth century.
Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principl ....Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principles as macroscopic machines. Comparing the artificial motor with biological motors will provide insight into the workings of natural motors. This project should lead to molecular motors for nanobiotechnology.Read moreRead less
Encoding Interactions and Printability into Hairy Colloidal Biomaterials. Printing mixtures of live cells and biomaterials (or 'BioInks') to make bespoke engineered tissues has the potential to enable personalised platforms for therapeutic discovery and organ replacement. Using a novel high throughput approach to materials synthesis, BioInk design and process optimisation, this project aims to discover new biomaterials and printing nozzles to help realise this potential. It will produce new insi ....Encoding Interactions and Printability into Hairy Colloidal Biomaterials. Printing mixtures of live cells and biomaterials (or 'BioInks') to make bespoke engineered tissues has the potential to enable personalised platforms for therapeutic discovery and organ replacement. Using a novel high throughput approach to materials synthesis, BioInk design and process optimisation, this project aims to discover new biomaterials and printing nozzles to help realise this potential. It will produce new insights in colloid science, cell-laden biomaterials design, and BioInk processing. Structure-property-function guides for colloid-based BioInks and quality-assured bioprinting as outcomes represent significant benefits for researchers and industries alike engaged in biofabrication, cell therapy and biotherapeutics.Read moreRead less
Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to a ....Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.Read moreRead less
Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
System identification of microstructure in the brain using magnetic resonance. Magnetic Resonance Imaging technologies will be exploited to probe the microstructure of the brain, using powerful Bayesian optimisation techniques and innovative uses of magnetic resonance. The project will in particular develop non-invasive imaging methods to quantify iron content in the brain, important for research on dementia and Alzheimer's disease.
Stability of nanoscale structures at the surface of metallic glasses. This project aims to develop advanced electrodes and catalysts for batteries and hydrogen generation. These technologies are crucial components in the efficient use of alternative energy supplies. The outcome of this project will be an accurate computer modelling tool for predicting nanoporous structures of metallic glass generated by de-alloying, and for establishing the role of various factors in determining the stability of ....Stability of nanoscale structures at the surface of metallic glasses. This project aims to develop advanced electrodes and catalysts for batteries and hydrogen generation. These technologies are crucial components in the efficient use of alternative energy supplies. The outcome of this project will be an accurate computer modelling tool for predicting nanoporous structures of metallic glass generated by de-alloying, and for establishing the role of various factors in determining the stability of metallic glass nanostructures. This work will include fundamental insights into glass surfaces and dissolution.Read moreRead less
Unpacking the immune system with applied mathematics. This project aims to model immune interactions across cells and structures spanning scales of nanometres to millimetres. It expects to develop innovative mathematical insights, improve our understanding of immunology, and consolidate collaborations with top American and European laboratories and groups. Expected outcomes include cutting-edge techniques for multiscale biological modelling and improved prediction and analysis of immune dynami ....Unpacking the immune system with applied mathematics. This project aims to model immune interactions across cells and structures spanning scales of nanometres to millimetres. It expects to develop innovative mathematical insights, improve our understanding of immunology, and consolidate collaborations with top American and European laboratories and groups. Expected outcomes include cutting-edge techniques for multiscale biological modelling and improved prediction and analysis of immune dynamics. The project should provide benefits to industries where highly organised behaviours are important, for example those interested in robot swarming, optimal transportation, and epidemic management. It should also benefit Australian students and researchers with novel overseas training opportunities.Read moreRead less
Understanding the properties of layered nanostructures using in-situ TEM. This project aims to support the practical applications of layered nanostructure-based devices and systems. The development of layered chalcogenide nanostructures is a global research focus due to their potential applications in the energy sector. However, their structure–property link is unclear due to the lack of direct correlation between their structure and properties. This project aims to establish the intrinsic struc ....Understanding the properties of layered nanostructures using in-situ TEM. This project aims to support the practical applications of layered nanostructure-based devices and systems. The development of layered chalcogenide nanostructures is a global research focus due to their potential applications in the energy sector. However, their structure–property link is unclear due to the lack of direct correlation between their structure and properties. This project aims to establish the intrinsic structure–property link by closely correlating the structure (and structural variations) and properties (and varied properties) simultaneously determined from individual nanostructures inside a transmission electron microscope. Expected project outcomes may advance the knowledge base, and provide guidelines for the development of nanostructure-based devices for their high-performance applications, especially in the energy sector.Read moreRead less
Strengthening urban slum upgrading and urban governance in cities in Southeast Asia. 1. Improve the approach to evaluating the impact of slum upgrading in building institutional capacity, and thereby, on the longer-term continuity of poverty reduction for poor communities. These lessons can be applied in impoverished settlements in developed and developing countries;
2. Enhance best practice in planning upgrading projects and design of governance frameworks. These lessons can be applied throu ....Strengthening urban slum upgrading and urban governance in cities in Southeast Asia. 1. Improve the approach to evaluating the impact of slum upgrading in building institutional capacity, and thereby, on the longer-term continuity of poverty reduction for poor communities. These lessons can be applied in impoverished settlements in developed and developing countries;
2. Enhance best practice in planning upgrading projects and design of governance frameworks. These lessons can be applied throughout Asia - a region to which Australia is closely linked;
3. Make a substantial contribution to scholarly literature on urban upgrading and governance;
4. Strengthen international linkages between Australian researchers and key scholars in the USA, Canada, Philippines, Vietnam and Indonesia.
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