Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to a ....Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.Read moreRead less
Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineerin ....Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineering.Read moreRead less
Meta-microscopy of insect tissue: How nature grows bicontinuous nanosolids. Several butterfly species grow a complex nano-sculptured matrix whose chiral network structure confers remarkable optical properties, including jewel-like reflections. The formation process remains mysterious and a spectacular case of bottom-up self-assembly at far larger scales than accessible in the lab. The project aims to decipher this process, by (a) tomography of a species where arrested growth sites represent time ....Meta-microscopy of insect tissue: How nature grows bicontinuous nanosolids. Several butterfly species grow a complex nano-sculptured matrix whose chiral network structure confers remarkable optical properties, including jewel-like reflections. The formation process remains mysterious and a spectacular case of bottom-up self-assembly at far larger scales than accessible in the lab. The project aims to decipher this process, by (a) tomography of a species where arrested growth sites represent time-frozen snapshots of the development, and (b) by a combination of micron-resolved in-vivo microscopy of a developing butterfly wing with a growth model to infer nanometer-scale information. This insight will lead to blueprints for self-assembly strategies and shed light on function and form of inner-cellular membranes. Read moreRead less
Improving transient performance for systems with multiple inputs/outputs. This project aims to develop and test new mathematical techniques for the improvement of transient performance in tracking control systems. The fundamental problem to be addressed will be the design of controllers to rapidly track constant and time varying target reference signals without overshooting or undershooting for multiple-input multiple-output systems/plants. These new methods aim to offer improved accuracy and sp ....Improving transient performance for systems with multiple inputs/outputs. This project aims to develop and test new mathematical techniques for the improvement of transient performance in tracking control systems. The fundamental problem to be addressed will be the design of controllers to rapidly track constant and time varying target reference signals without overshooting or undershooting for multiple-input multiple-output systems/plants. These new methods aim to offer improved accuracy and speed in many engineering applications.Read moreRead less
Pressure waves on the mechanics of earthquakes and faulting. This project aims to decipher the physics of faulting and earthquakes from damage zones around seismogenic faults. It will examine a mechanism for instability in solids: volumetric collapse due to a dissipative pressure wave. This pressure wave may control damage-zone geometry and relate to earthquake stress and rock material properties. The project will research the instability through theoretical, laboratory and field studies. Antici ....Pressure waves on the mechanics of earthquakes and faulting. This project aims to decipher the physics of faulting and earthquakes from damage zones around seismogenic faults. It will examine a mechanism for instability in solids: volumetric collapse due to a dissipative pressure wave. This pressure wave may control damage-zone geometry and relate to earthquake stress and rock material properties. The project will research the instability through theoretical, laboratory and field studies. Anticipated outcomes include advances in earthquake and fault prediction, tools to determine the stress state and material properties of Earth’s crust, and knowledge of a class of solid instabilities.Read moreRead less
Lunar crustal structure from high-res gravity, topography, and seismic data. This project aims to improve our knowledge of the Moon, including its surface processes, interior structure, modification by geological processes and creation and evolution. The Moon preserves the longest and cleanest records of surface geology in the Solar System’s history, unlike the Earth. The lunar crust should exhibit strong heterogeneity in density (both porosity and composition) given its complex history of impac ....Lunar crustal structure from high-res gravity, topography, and seismic data. This project aims to improve our knowledge of the Moon, including its surface processes, interior structure, modification by geological processes and creation and evolution. The Moon preserves the longest and cleanest records of surface geology in the Solar System’s history, unlike the Earth. The lunar crust should exhibit strong heterogeneity in density (both porosity and composition) given its complex history of impact bombardment and volcanism. This project aims to determine radial and lateral heterogeneity in density and porosity within the Moon's crust, by analysing Gravity Recovery And Interior Laboratory gravity and spacecraft tracking data, Lunar Orbiter Laser Altimeter topography and in situ Apollo seismological data.Read moreRead less
Understanding graphitization: developing a model for activated carbons. For over 60 years it has remained a puzzle why some carbons graphitise under heating while others do not. The question is of practical importance as oxidation of non-graphitising carbons produces activated carbon, a product of high value with industrial, medical and environmental applications. Using computational and experimental techniques the project will study the graphitisation process and pinpoint the structural element ....Understanding graphitization: developing a model for activated carbons. For over 60 years it has remained a puzzle why some carbons graphitise under heating while others do not. The question is of practical importance as oxidation of non-graphitising carbons produces activated carbon, a product of high value with industrial, medical and environmental applications. Using computational and experimental techniques the project will study the graphitisation process and pinpoint the structural elements which inhibit it. Based on these findings the project aims to develop a nanoscale atomistic model for activated carbons. This is expected to be an important contribution to the field of chemical engineering in which current models of activated carbon neglect either curvature in the network or the presence of oxygen.Read moreRead less
Fleshing out the fossil record: using organically preserved soft tissues and bone to explore the evolution of unique vertebrate characters. This study integrates developmental, molecular and morphological data in both fossil and living species to provide insights into the evolutionary mechanisms which formed the musculo/skeletal system. Uncovering these evolutionary pathways has the potential to describe mechanisms common to all vertebrate and informs us about our own evolution.
Nanoscale liquid interfaces: properties and molecular sensitivity. Challenges facing society in health and environment need new molecular measurements that are accurate, sensitive and fast. By use of nanoscale oil-water junctions, the project will develop new chemical and biological sensors that hold great promise for solving molecular measurement problems, including the ability to detect single molecules.