Controlling the organisation of matter using vortex fluidics. Vortex fluidic devices will be developed and used to construct functional complex molecules and materials, and probe the structure of self assembled systems. The scalable processing will be assessed for application in advanced materials production, the chemical industry and in developing complex molecules for drug discovery.
Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lip ....Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lipid biology at the cellular and sub-cellular level across a wide range of in vitro and in vivo models. The outcomes of this project should provide significant knowledge to tackle modern societal challenges in healthy ageing, brain pathologies and neurodegenerative diseases.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less
State-trace analysis: theory and application. A fundamental question for the science of psychology is: how can we identify the functional components of the human mind from observed behaviour and bodily states? This project explores this question through a new methodology called state-trace analysis and apply it to a basic cognitive ability - the capacity to learn to classify different objects.
Microbially induced calcium carbonate precipitation in different substrates. Carbonates in the form of limestone represent an important reservoir of carbon on earth. They are recorded in several natural geological formations as corals, stromatolites, beach rocks. Microbes play an important role in the formation as well as dissolution of carbonates during microbially induced calcium carbonate precipitation (MICP) reactions on different substrates in natural and built environments. Much of our kno ....Microbially induced calcium carbonate precipitation in different substrates. Carbonates in the form of limestone represent an important reservoir of carbon on earth. They are recorded in several natural geological formations as corals, stromatolites, beach rocks. Microbes play an important role in the formation as well as dissolution of carbonates during microbially induced calcium carbonate precipitation (MICP) reactions on different substrates in natural and built environments. Much of our knowledge on MICP is limited due to poor understanding of the reaction kinetics at a molecular level. This project will develop new methods to enable and advance the knowledge of MICP process with profound implications for understanding natural geological formations as well as widen the scope of current engineering applications.Read moreRead less
Physiology of oxygen transport in the mammalian kidney. This project aims to improve understanding of oxygen regulation in renal tissue and knowledge of the physiology of the kidney. The mammalian kidney receives more oxygen than it uses or needs, and yet renal tissue is commonly found to be hypoxic. This project proposes that oxygen transport to the renal tissue is limited by blood vessel surface area. The project expects to generate anatomical data currently missing from the renal physiology c ....Physiology of oxygen transport in the mammalian kidney. This project aims to improve understanding of oxygen regulation in renal tissue and knowledge of the physiology of the kidney. The mammalian kidney receives more oxygen than it uses or needs, and yet renal tissue is commonly found to be hypoxic. This project proposes that oxygen transport to the renal tissue is limited by blood vessel surface area. The project expects to generate anatomical data currently missing from the renal physiology community, and potentially change the accepted story of oxygen homeostasis in the kidney. This will provide significant benefits, such as the provision of the foundational physiological science behind a determinant of kidney health and its flow-on impact to quality of life.Read moreRead less
Building Central Asia: Linking the Growth of Asia to its Exhumation. The consumption of the Tethys Ocean and the associated collision of Gondwana-derived terranes with Eurasia resulted in the uplift of the highest mountain belt on Earth: the Himalayas. However, stresses from this collision zone propagated far into the Eurasian interior by reactivating faults and creating mountain belts along these fault zones. This project aims to map and model how and when fault (re)activation occurred by integ ....Building Central Asia: Linking the Growth of Asia to its Exhumation. The consumption of the Tethys Ocean and the associated collision of Gondwana-derived terranes with Eurasia resulted in the uplift of the highest mountain belt on Earth: the Himalayas. However, stresses from this collision zone propagated far into the Eurasian interior by reactivating faults and creating mountain belts along these fault zones. This project aims to map and model how and when fault (re)activation occurred by integrating multi-method thermochronological and structural data on major Meso-Cenozoic Central Asian fault systems. The resulting time-integrated tectonic model will aid in the understanding of the India-Eurasia collision, the building of the mountainous Central Asian landscape and its influence on the Asian climate.Read moreRead less
What drives parasite spread through social networks: lessons from lizards. Australia's biodiversity is continually threatened by new epidemics of local and foreign diseases and parasites. This project will enhance our understanding of how these diseases spread, allowing more effective controls to be developed to protect wildlife species, animal populations and, ultimately, Australian ecosystems.
Understanding vibratory piles in sand: installation and lateral response. This project aims to address uncertainties in the design of vibro-driven piles. This promising alternative to impact-driven piles offers faster installation and requires no noise mitigation. The project expects to generate new knowledge of the effect of the installation process in sand on in-service pile response by integrating findings from innovative experiments and numerical modelling. This is particularly important for ....Understanding vibratory piles in sand: installation and lateral response. This project aims to address uncertainties in the design of vibro-driven piles. This promising alternative to impact-driven piles offers faster installation and requires no noise mitigation. The project expects to generate new knowledge of the effect of the installation process in sand on in-service pile response by integrating findings from innovative experiments and numerical modelling. This is particularly important for highly sensitive structures such as offshore wind turbines, which provide a rapidly increasing share of global energy supply. Expected outcomes include practical recommendations for vibro-piles in sand. This should provide sizeable benefits by unlocking vibro-piles as a viable method to reduce offshore wind farm costs.Read moreRead less
A detrital apatite archive to track crustal growth. This project will establish apatite as a new tool to study the evolution of the continental crust. The crust shaped the composition of the atmosphere and the oceans with consequences for the evolution of life through the availability of oxygen and nutrients. However, when and how the continental crust was generated remains a core question. Current models for continental crust development rely on the mineral zircon. However, zircons only record ....A detrital apatite archive to track crustal growth. This project will establish apatite as a new tool to study the evolution of the continental crust. The crust shaped the composition of the atmosphere and the oceans with consequences for the evolution of life through the availability of oxygen and nutrients. However, when and how the continental crust was generated remains a core question. Current models for continental crust development rely on the mineral zircon. However, zircons only record the history of evolved rocks. To address this bias we will use the mineral apatite which forms in less evolved rocks. We will develop a detrital apatite database of Pb-Nd (model) ages and integrate this with the zircon record to provide a more holistic description for how our planet developed.Read moreRead less