Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
Pressure waves on the mechanics of earthquakes and faulting. This project aims to decipher the physics of faulting and earthquakes from damage zones around seismogenic faults. It will examine a mechanism for instability in solids: volumetric collapse due to a dissipative pressure wave. This pressure wave may control damage-zone geometry and relate to earthquake stress and rock material properties. The project will research the instability through theoretical, laboratory and field studies. Antici ....Pressure waves on the mechanics of earthquakes and faulting. This project aims to decipher the physics of faulting and earthquakes from damage zones around seismogenic faults. It will examine a mechanism for instability in solids: volumetric collapse due to a dissipative pressure wave. This pressure wave may control damage-zone geometry and relate to earthquake stress and rock material properties. The project will research the instability through theoretical, laboratory and field studies. Anticipated outcomes include advances in earthquake and fault prediction, tools to determine the stress state and material properties of Earth’s crust, and knowledge of a class of solid instabilities.Read moreRead less
The social dynamics of language: a study of phonological variation and change in West Australian English. This project studies the role of pronunciation as a marker of individual and community identity. As the first systematic study of accent variability in Perth, it focusses on how, across different contexts, speakers from older and younger generations and different backgrounds deploy speech as a means of projecting social affiliation and difference.
Illuminating hidden processes in emissive lanthanoid complexes. This project aims to understand the antenna effect used to sensitise lanthanoid luminescence. Despite their use in modern high-tech applications, from optical fibre amplifiers (telecommunications) to luminescent probes and sensors (biological imaging), understanding is largely based on speculation or generalised 'rules-of-thumb', severely limiting progress in the field. This project will research these processes, using chemical synt ....Illuminating hidden processes in emissive lanthanoid complexes. This project aims to understand the antenna effect used to sensitise lanthanoid luminescence. Despite their use in modern high-tech applications, from optical fibre amplifiers (telecommunications) to luminescent probes and sensors (biological imaging), understanding is largely based on speculation or generalised 'rules-of-thumb', severely limiting progress in the field. This project will research these processes, using chemical synthesis, theory and spectroscopic techniques. This is expected to lead to new emissive lanthanoid-based compounds using 'a priori' approaches, with better performance than current gold standards and references. Intellectual property created will lead to new commercial products, and to creation of new Australian based spin-off/start-up companies.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less
Oxide-based high temperature proton exchange membrane fuel cells. Proton exchange membrane fuel cells (PEMFCs) are one of the most efficient energy conversion technologies for producing electricity from fuels such as hydrogen and methanol. Current PEMFCs use precious metal catalysts, and the performance of liquid methanol fuel is disappointingly low due to the inability of polymer or hybrid membranes to operate at temperatures above 160-180 degrees centigrade. This work aims to develop an all ox ....Oxide-based high temperature proton exchange membrane fuel cells. Proton exchange membrane fuel cells (PEMFCs) are one of the most efficient energy conversion technologies for producing electricity from fuels such as hydrogen and methanol. Current PEMFCs use precious metal catalysts, and the performance of liquid methanol fuel is disappointingly low due to the inability of polymer or hybrid membranes to operate at temperatures above 160-180 degrees centigrade. This work aims to develop an all oxide-based PEMFC technology using a recently developed sintered and heteropolyacid functionalised mesoporous silica membrane. The utilisation of all-oxide-PEMFCs using non-precious metal catalysts is expected to significantly enhance the power density, reduce costs, and enhance the commercial viability of PEMFC technologies.Read moreRead less
Finite Strain with large rotations: A new hybrid numerical/experimental approach. Deformation up to large strains and rotations is important in rocks, metals, polymers, and biomaterials. Computational mechanics is a standard tool for modelling such deformations. However, in earth sciences, mechanical theories use small-strain formulations or large-strain approaches with classical stress rates. Classical stress rates can lead to incorrect stored energies. This project proposes to test a new large ....Finite Strain with large rotations: A new hybrid numerical/experimental approach. Deformation up to large strains and rotations is important in rocks, metals, polymers, and biomaterials. Computational mechanics is a standard tool for modelling such deformations. However, in earth sciences, mechanical theories use small-strain formulations or large-strain approaches with classical stress rates. Classical stress rates can lead to incorrect stored energies. This project proposes to test a new large-strain theory tailored to rocks experimentally, and to apply it to a pivotal geological problem: shear zone formation. The project will advance our fundamental understanding of the mechanics and energetics of rock deformation and provide a novel tool for the modelling of large deformations.Read moreRead less
Porous beta-titanium bone implants optimised for strength and bio-compatibility: design and fabrication. The project aims to develop the scaffold-design and manufacturing techniques that will underpin the next generation of bone implants. The scaffolds will be specifically designed to match the key biomechanical properties of bone, and fabricated from novel titanium alloys using the latest generation of advanced manufacturing technologies.
New mesoporous materials for use in high temperature proton exchange fuel cell membranes. A novel high temperature proton exchange membrane based on heteropolyacid (HPA) functionalised mesoporous silica will be developed. This research into the fundamental materials science of novel proton exchange membranes is expected to impact significantly on the advancement and commercialisation of portable fuel cell devices.
Neurodevelopmental disorders and loneliness: School predictors & outcomes. This project aims to establish trajectories of loneliness across the 10-18 year developmental period in adolescents with neuro-developmental disorders (NDDs). This is significant because adolescence is the peak period for loneliness and the social communication difficulties experienced by adolescents with NDDs place them at greater risk of loneliness. Lower levels of school attendance, connectedness and mental well-being, ....Neurodevelopmental disorders and loneliness: School predictors & outcomes. This project aims to establish trajectories of loneliness across the 10-18 year developmental period in adolescents with neuro-developmental disorders (NDDs). This is significant because adolescence is the peak period for loneliness and the social communication difficulties experienced by adolescents with NDDs place them at greater risk of loneliness. Lower levels of school attendance, connectedness and mental well-being, and higher rates of disruptive behaviour, expulsion, drop-out, depression, social withdrawal, and suicide ideation are strongly linked to loneliness. Therefore predicting critical times in trajectories will enhance emotional, behavioural and school related outcomes and optimise economic, societal and quality of life benefits.Read moreRead less