Marine sponge–microbe interactions and the origin of animal innate immunity. This project aims to address how the animal innate immune system evolved to discriminate between potential pathogens versus beneficial symbionts by studying a marine sponge holobiont. Using advanced genomic and cellular approaches, the project will uncover deeply conserved regulatory pathways used by the cells of sponges, humans and other animals, and thereby identify cardinal rules governing animal innate immunity and ....Marine sponge–microbe interactions and the origin of animal innate immunity. This project aims to address how the animal innate immune system evolved to discriminate between potential pathogens versus beneficial symbionts by studying a marine sponge holobiont. Using advanced genomic and cellular approaches, the project will uncover deeply conserved regulatory pathways used by the cells of sponges, humans and other animals, and thereby identify cardinal rules governing animal innate immunity and its evolutionary origin. The project will provide an understanding of how beneficial microbial symbionts are recruited and maintained by animals, and are instrumental to the health of our environment and all its inhabitants.Read moreRead less
Evolutionary genetics of the immune system in social insects. Insects possess efficient innate immunity against pathogens, but social insects are suggested to be vulnerable due to their packed colonies of related individuals. We predict that pathogen pressure varies with life history and microhabitat details, and that this variation will be reflected in the molecular evolutionary rates of immune system genes. Sequence information will be obtained to test these predictions. The results should ....Evolutionary genetics of the immune system in social insects. Insects possess efficient innate immunity against pathogens, but social insects are suggested to be vulnerable due to their packed colonies of related individuals. We predict that pathogen pressure varies with life history and microhabitat details, and that this variation will be reflected in the molecular evolutionary rates of immune system genes. Sequence information will be obtained to test these predictions. The results should be of widespread interest as reflecting the importance of pathogens and life pattern, and increase our knowledge of insect immune systems, potentially enabling circumvention of pest defenses and better protection of beneficial species.Read moreRead less
Evolutionary immunology of social insects. Social insects are particularly abundant in Australia. They live in a wide range of habitats with social systems differing greatly in size and structure. They are both ecologically and economically important because they form a large part of terrestrial ecosystems and control much of the energy flow. Their immune system resembles the immune system of humans. Finding how the social insect immune system evolves will have the potential to help us manag ....Evolutionary immunology of social insects. Social insects are particularly abundant in Australia. They live in a wide range of habitats with social systems differing greatly in size and structure. They are both ecologically and economically important because they form a large part of terrestrial ecosystems and control much of the energy flow. Their immune system resembles the immune system of humans. Finding how the social insect immune system evolves will have the potential to help us manage them better, and yield functional insights into the human innate immune system. Placing the observed patterns in context also involves study of the associated microbes, finds how social insects interact with this important part of the environment, and may assist in land management.Read moreRead less