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Targeting The Canonical Wnt Signalling Pathway To Promote Central Nervous System Remyelination In Vivo
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Multiple Sclerosis (MS) occurs when immune cells attack the sheaths, called myelin, that cover and protect nerve connections. If myelin is damaged nerve cells cannot function properly, leading to severe disability. The brain has a group of cells that could potentially replace damaged myelin, but as MS worsens these cells are blocked in a state where they cannot help in repair. I will remove a signal specifically from these cells and determine if this unblocks them resulting myelin repair.
Multiple sclerosis is a particularly devastating disease that affects people early in their lives. This chronic disabling condition is characterized by inflammation and loss or damage to the myelin sheath that surrounds axons. There is preliminary evidence suggesting that certain cell signals may prevent the cells that produce myelin from death in multiple sclerosis. This study will seek to determine how and which signals prevent cell death and whether this may be a potential therapeutic interve ....Multiple sclerosis is a particularly devastating disease that affects people early in their lives. This chronic disabling condition is characterized by inflammation and loss or damage to the myelin sheath that surrounds axons. There is preliminary evidence suggesting that certain cell signals may prevent the cells that produce myelin from death in multiple sclerosis. This study will seek to determine how and which signals prevent cell death and whether this may be a potential therapeutic intervention.Read moreRead less
Tremor And Cognition In Multiple Sclerosis: Implementing Novel Treatments And Computerized Monitoring Strategies.
Funder
National Health and Medical Research Council
Funding Amount
$303,014.00
Summary
This research program aims to study two disabling symptoms of multiple sclerosis namely upper limb shaking, or tremor, and memory dysfunction. The first project will develop a new treatment for MS arm tremor, Botulinum toxin injections, into routine clinical practice. The second project aims to make available a computerised test of memory that can be done in clinic waiting rooms or at home. This will help neurologists to rapidly pick up changes in memory in a person with MS and improve care.
Is Kainate Receptor Dysfunction At The Core Of Multiple Sclerosis Neuropathology?
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Multiple Sclerosis (MS) is a devastating disease. The current treatments for MS are not able to prevent the death of cells in the brain and are not able to prevent disability in MS patients. I have identified a family of genes that I predict are responsible for cell death in MS. I will determine what these genes do in the brain. My aim is to identify a target for new treatments to prevent cell death in MS.
Causes Of Multiple Sclerosis: A Functional Genomics Approach
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Multiple sclerosis (MS) is a chronic disease that damages the brain and spinal cord and can cause, numbness, muscle weakness, difficulties with coordination and balance, problems with speech and swallowing, visual problems, fatigue and bladder and bowel difficulties. After a world-wide effort, a large number of multiple sclerosis genes have been localized in the human genome. This project examines three of these in detail aiming to identify exactly how they contribute to the risk of developing M ....Multiple sclerosis (MS) is a chronic disease that damages the brain and spinal cord and can cause, numbness, muscle weakness, difficulties with coordination and balance, problems with speech and swallowing, visual problems, fatigue and bladder and bowel difficulties. After a world-wide effort, a large number of multiple sclerosis genes have been localized in the human genome. This project examines three of these in detail aiming to identify exactly how they contribute to the risk of developing MSRead moreRead less
IDENTIFYING AND MODIFYING LIFESTYLE RISK FACTORS TO IMPROVE HEALTH OUTCOMES IN MULTIPLE SCLEROSIS
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Multiple Sclerosis (MS) is a neurological disorder affecting ~25000 Australians. Promising evidence is emerging that modifying lifestyle factors such as smoking, diet, exercise, stress and vitamin D can affect the disease and health outcomes. I propose to study the effects of these factors over time, and to design an online intervention targeting these risk factors. The intervention, if found effective, can be incorporated into MS management to help people with MS live healthier for longer.
Investigating The Neural Mechanisms Of Visual Recovery After Acute Optic Neuritis
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Patients with multiple sclerosis experience relapses followed by disease remission. Recently, neuroplasticity, or the brain's innate ability to reorganise itself to maintain function after injury, has been thought to play a significant role in remission. We study patients with optic neuritis, which causes loss of vision, to understand visual parts of the brain change during recovery to enable patients to see again despite ongoing brain injury.
Towards Improved Maternal And Childhood Vaccine Uptake: Managing The Challenge And Opportunity Of Complementary Medicine Practitioners
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Certain geographical areas with lower rates of vaccination pose considerable concern. Complementary medicine practitioners are often visited by vaccine-hesitant parents and are influential in their decisions about vaccination. This research provides the first examination of complementary medicine practitioner beliefs and practices regarding vaccination. Resources will be developed to help manage conversations between complementary medicine practitioners and vaccine-hesitant parents.