Ischaemic Stroke And Atrial Fibrillation: Development Of A Novel Artificial Intelligence System Using Magnetic Resonance Imaging
Funder
National Health and Medical Research Council
Funding Amount
$92,335.00
Summary
Atrial fibrillation (AF) is an abnormal heart rhythm which is a common cause of stroke. AF can often go unrecognized as patients may have no symptoms. This project aims to develop computer software which can automatically detect underlying AF based on MRI brain scan pattern, in patients who have had an acute stroke. This project has the potential to offer several benefits, including reduced need for costly investigations, improved AF detection and a larger pool of patients being treated for AF.
Pain has a detrimental impact on ones quality of life and a significant financial impact on the community. Although some of the pathways that code pain in the brain have been defined, it was recently proposed that there also exists a pain-specific pathway in humans. Using human brain imaging, we aim to determine if such a pathway exists and if it is altered in subjects with chronic pain. The existence of such a pathway would significantly aid in the development of better treatment regimes.
Structural And Functional Networks In The Human Brain: Disturbance In Disease And Influence Of Genes.
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
Professor Graeme Jackson is a Neurologist at the Austin Hospital whose research is dedicated to the problem of understanding how epilepsy occurs and devising strategies for successful treatment. He is Deputy Director and head of the epilepsy division of the Florey Neuroscience Institutes which has research dedicated advanced MR imaging systems and physics support largely dedicated to solving these problems in epilepsy. He has 170 plus papers, 10 cited over 200 times. Career citations exceed 6000 ....Professor Graeme Jackson is a Neurologist at the Austin Hospital whose research is dedicated to the problem of understanding how epilepsy occurs and devising strategies for successful treatment. He is Deputy Director and head of the epilepsy division of the Florey Neuroscience Institutes which has research dedicated advanced MR imaging systems and physics support largely dedicated to solving these problems in epilepsy. He has 170 plus papers, 10 cited over 200 times. Career citations exceed 6000.Read moreRead less
We have previously made the most widely used animal brain atlas in the world. This atlas based on stained histological sections of the rat brain. In recent years, advances in MRI have made it possible to generate images of the rat brain at very high resolution. We have obtained a very high quality MRI image set from colleagues in Duke University in the USA, and we have begun to map these images in great detail, using our histological atlas as a guide.
Novel Nanomaterial Solutions Based On Metal And Metal Oxide For Advanced Diagnosis Of Cardiovascular Diseases
Funder
National Health and Medical Research Council
Funding Amount
$581,037.00
Summary
Cardiovascular disease accounts of over one third of all deaths in Australia and is forecasted to become the leading cause of death in Australia and worldwide. Currently, atherosclerosis and thrombosis in coronary arteries are diagnosed by X-ray angiography, an invasive and risk-associated procedure. Our project will explore new contrast agents for the fast, reliable and safe diagnosis of cardiovascular diseases and thrombotic events, which is beneficial to many patients.
Imaging Of Acute Ischemic Stroke – Improving Patient Selection For Thrombolysis
Funder
National Health and Medical Research Council
Funding Amount
$367,946.00
Summary
Stroke is a major cause of death and disability in our community and is most often due to a blocked blood vessel. Powerful treatments are available to open blocked blood vessels but there are restrictions on eligibility and some risks. This research aims to improve doctors' understanding of stroke in the individual patient to aid treatment decisions by identifying those with potentially salvageable brain tissue and avoiding those with high risk of bleeding complications.
Improving Human FMRI Through Modeling And Imaging Microvascular Dynamics
Funder
National Health and Medical Research Council
Funding Amount
$486,144.00
Summary
In this project we aim to establish a reliable vascular baseline to improve mapping of both small-scale functional architecture and large-scale brain networks in functional human brain mapping using MRI. By mapping the grey matter vasculature with high detail in both humans and animals, and by computing and matching of these atlases across species we will be able to validate this approach in vivo to confirm the better spatial specificity of the newly developed approach.
The Australian MRI-Linac Program: Transforming The Science And Clinical Practice Of Cancer Radiotherapy
Funder
National Health and Medical Research Council
Funding Amount
$7,001,475.00
Summary
Radiotherapy is indicated for 48% of cancer patients. The Australian MRI-Linac Program will change the science and clinical practice of radiotherapy by explicitly targeting the dynamic anatomy and physiology of cancer, increasing cancer control and decreasing treatment side effects. Successful completion of this program will have a direct impact on the treatment and lives of Australian cancer patients in the foreseeable future.
Structural Connectomes In Traumatic Brain Injury: Can Secondary Disease Progression Be Stopped And Cognitive Deficits Be Reversed?
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Many people with traumatic brain injury (TBI) experience cognitive problems, including poor memory and concentration. TBI is often referred to as a ‘hidden disability’ because the overwhelming majority of patients with TBI show no abnormalities on standard MRI or CT scans. In my project, I will delineate the mechanisms of secondary injury in finer detail through enhanced neuroimaging techniques, resulting in new assessment and treatment modalities for individuals with TBI.