An Integrated Approach Towards Development of Highly Specific Chemotherapeutics. Many diseases are caused or can be treated by modifying the activities of particular enzymes. Molecules that affect enzymatic activities have potential as therapeutic agents. A successful approach to the discovery of new drug molecules is to design them based on very detailed knowledge of how the target enzyme works. In this project, a highly motivated team of scientists will use state of the art instruments and the ....An Integrated Approach Towards Development of Highly Specific Chemotherapeutics. Many diseases are caused or can be treated by modifying the activities of particular enzymes. Molecules that affect enzymatic activities have potential as therapeutic agents. A successful approach to the discovery of new drug molecules is to design them based on very detailed knowledge of how the target enzyme works. In this project, a highly motivated team of scientists will use state of the art instruments and their combined creativity to understand the intimate details of how one large group of enzymes work. The enzymes selected are the bimetallic hydrolases, many of which are associated with disorders including osteoporosis, mental illnesses, cystic fibrosis and various types of cancer.Read moreRead less
Emergent Behaviours in Spin Crossover Materials. This project aims to develop new molecular materials in which the incorporation of electronic switching leads to the emergence of fundamentally new chemical and physical phenomena. Through an innovative interdisciplinary approach that targets interesting new forms of interplay at the nanoscale this project expects to generate step-change advances in the understanding of spin-switching materials. Significant anticipated outcomes and benefits includ ....Emergent Behaviours in Spin Crossover Materials. This project aims to develop new molecular materials in which the incorporation of electronic switching leads to the emergence of fundamentally new chemical and physical phenomena. Through an innovative interdisciplinary approach that targets interesting new forms of interplay at the nanoscale this project expects to generate step-change advances in the understanding of spin-switching materials. Significant anticipated outcomes and benefits include identification and development of several new classes of materials function, each of major fundamental interest, and to the generation of advanced new materials worthy of commercial development in electronic device, actuator, sensor and gas separations technologies.Read moreRead less