Discovery Early Career Researcher Award - Grant ID: DE210100065
Funder
Australian Research Council
Funding Amount
$423,808.00
Summary
Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body ....Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body - even water - into visible tracers. The expected outcomes of this project include the synthesis and understanding of these catalysts which will be chemically fine-tuned to maximise their effectiveness. Potential benefits include translation to MRI applications to improve diagnosis and treatment, or chemical monitoring.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100057
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A diffractometer for small molecule structural elucidation by crystallographic analysis. X-ray diffractometry provides an unambiguous means of identifying the three-dimensional spatial arrangement of atoms within molecules affording important insights into the origins of chemical properties. A modern diffractometer will provide information to help develop new functional materials, therapeutic agents and environmentally sustainable processes.
Tags and algorithms for studies of protein structures and interactions. This project aims to develop a new set of tools to structurally characterise protein-protein and protein-ligand interactions that are difficult or impossible to analyse by other means, facilitate tracking of proteins in biological material and identify interaction partners. The project seeks to focus on the synthesis of new unnatural amino acids and tags for site-specific protein labelling, and a range of techniques for 3D s ....Tags and algorithms for studies of protein structures and interactions. This project aims to develop a new set of tools to structurally characterise protein-protein and protein-ligand interactions that are difficult or impossible to analyse by other means, facilitate tracking of proteins in biological material and identify interaction partners. The project seeks to focus on the synthesis of new unnatural amino acids and tags for site-specific protein labelling, and a range of techniques for 3D structure analysis in solution, in particular NMR spectroscopy. New algorithms are expected to be developed for optimizing NMR spectroscopy and structure calculations from sparse data. The integrated set of tools is expected to deliver better and faster structure analysis and target characterisation to accelerate early stages of drug discovery.Read moreRead less