Dopamine-2 Receptor Antibody In Movement And Psychiatric Disorders
Funder
National Health and Medical Research Council
Funding Amount
$415,783.00
Summary
Autoimmune movement and psychiatric disorders are a common cause of neurological disability young adults and adolescents. We have identified a subgroup of patients whose disease is associated with an autoimmune reaction. Our study will identify the earliest immune responses against the brain in children with autoimmune movement and psychiatric disorders. Identifying these early immune responses will allow early and directed treatments to prevent disability and death in the future.
Lipophilic Iron Chelators As Potential Therapeutic Agents In Parkinson's Disease
Funder
National Health and Medical Research Council
Funding Amount
$616,537.00
Summary
The impaired coordination and tremors experienced by the 64,000 Australians with Parkinson’s disease make managing life at work and home difficult. With 240,000 Australians projected to be living with Parkinson’s disease by 2033, the discovery of agents that slow or stop disease progression is urgent. Iron in the brain has been implicated in Parkinson’s disease. In this project, the performance of new low toxicity agents in altering brain iron distribution will be studied as potential drugs for ....The impaired coordination and tremors experienced by the 64,000 Australians with Parkinson’s disease make managing life at work and home difficult. With 240,000 Australians projected to be living with Parkinson’s disease by 2033, the discovery of agents that slow or stop disease progression is urgent. Iron in the brain has been implicated in Parkinson’s disease. In this project, the performance of new low toxicity agents in altering brain iron distribution will be studied as potential drugs for Parkinson’s disease.Read moreRead less
Calpeptin, And Related Candidates, For The Treatment Of Machado Joseph Disease
Funder
National Health and Medical Research Council
Funding Amount
$888,040.00
Summary
Machado Joseph Disease (MJD) is a neurodegenerative disease that causes impaired movement and progressive paralysis, leading to patient death. MJD is inherited within families, including a high number of Indigenous families of northeast Arnhem Land. We have identified a possible treatment for MJD that has positive effects on a small animal model of the disease (zebrafish carrying the human MJD gene). We plan to test this treatment further with the aim of developing a treatment for MJD patients.
Sensory Cortex Processing Changes Underlying Brain And Behaviour Deficits Caused By Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$576,795.00
Summary
Traumatic brain injury (TBI) from physical head trauma causes behavior and cognitive deficits. The burden for victims, families and the community is enormous: total life-time expenses in moderate-to-severe TBI are estimated to be $8.6 billion in Australia. We aim to elucidate whether changes in how the brain processes sensory information could underlie TBI-induced deficits in complex behaviour and whether these changes will be ameliorated by the three currently-most-promising treatments for TBI.
RESTORE - Individualised Movement Rehabilitation And Movement Sensor Biofeedback For Chronic, Disabling Low Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$1,214,385.00
Summary
Low back pain is the leading cause of disability in Australia, with an enormous cost burden for society. Available treatments have resulted in only moderate improvements that typically do not last. We propose to investigate the clinical- and cost-effectiveness of two new treatments that have shown promising early results: i) an individualised movement and cognitive rehabilitation approach (‘Cognitive Functional Therapy’) and ii) biofeedback from wireless movement sensors worn on the spine