Deregulated Cytokine Signalling As A Molecular Bridge Linking The Pathogenesis Of Emphysema To Lung Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$524,820.00
Summary
Lung cancer is the most lethal form of cancer in Australia and worldwide. Although smokers with emphysema are at an increased risk of developing lung cancer, it is becoming apparent that emphysema can predispose to lung cancer independently of cigarette smoking, albeit by unknown mechanisms. Our aim is to combine smoke carcinogen and genetic mouse models of lung cancer with novel mouse strains displaying emphysema to identify the processes which link the pathogenesis of emphysema to lung cancer.
Identification Of New Therapeutic Targets In Neuroblastoma Through ABCC Transporter Associated Pathways.
Funder
National Health and Medical Research Council
Funding Amount
$591,436.00
Summary
Neuroblastoma accounts for 15% of childhood cancer deaths. Children diagnosed over 1 year have survival rates below 40%. New research shows that certain genes previously implicated in drug resistance contribute to neuroblastoma development. We will investigate their role using a new neuroblastoma model and a range of biochemical and cell biology techniques. This research will improve our understanding of neuroblastoma biology and identify new therapeutic targets in this and other cancers.