Establishing Australian Health Based Targets For Microbial Water Quality
Funder
National Health and Medical Research Council
Funding Amount
$174,799.00
Summary
It is of great public health importance to ensure that our drinking water supplies are safe. This is true both for conventional drinking water supplies and for supplies derived from alternative water sources, including water derived from recycled sewage. National guidelines exist for management of drinking water and recycled water supplies, but currently there are no targets for determining whether water has an acceptably low level of infectious agents. This project involves a number of steps to ....It is of great public health importance to ensure that our drinking water supplies are safe. This is true both for conventional drinking water supplies and for supplies derived from alternative water sources, including water derived from recycled sewage. National guidelines exist for management of drinking water and recycled water supplies, but currently there are no targets for determining whether water has an acceptably low level of infectious agents. This project involves a number of steps to develop national consensus on health targets for microbial water qualityRead moreRead less
Men, Women And Ageing: Predictors Of Ageing Well In The Australian Longitudinal Study On Womens Health And The Perth He
Funder
National Health and Medical Research Council
Funding Amount
$1,935,634.00
Summary
Maintaining health and independent living are high priorities for Australia’s rapidly expanding older population. This project capitalizes on two existing large-scale studies, to increase our scientific understanding of strategies for maintaining the health and wellbeing of older people living in the community. Two separate longitudinal research projects, the Australian Longitudinal Study on Women’s Health involving over 12,000 older women selected from every part of Australia, and the Health in ....Maintaining health and independent living are high priorities for Australia’s rapidly expanding older population. This project capitalizes on two existing large-scale studies, to increase our scientific understanding of strategies for maintaining the health and wellbeing of older people living in the community. Two separate longitudinal research projects, the Australian Longitudinal Study on Women’s Health involving over 12,000 older women selected from every part of Australia, and the Health in Men Study involving over 12,000 older men from Perth, Western Australia, have been following older Australians in order to determine what contributes to older people’s health and quality of life. The new project will combine data from these two studies. The two projects contain a breadth of data and can address the following questions: What health-related, personal, lifestyle and social factors predict survival and healthy non-disabled life in men and women aged 70-90 years? Do changes in lifestyle in older age (eg smoking cessation) affect length and quality of life? Who makes greatest use of health services, and who least, and how does this relate to health outcomes?How are health and lifestyle factors related to social connectedness and independent living in older age? What health and lifestyle factors predict positive mental health in older age? How are older men’s and women’s lifestyles and health status different, and how are they the same? Should health promotion programs in old age target men and women separately, or not?Read moreRead less
Metabolic Syndrome, Inflammation And Non-alcoholic Fatty Liver Disease In Busselton
Funder
National Health and Medical Research Council
Funding Amount
$351,300.00
Summary
The metabolic syndrome is a clustering of obesity, insulin resistance, high cholesterol and high blood pressure. It could affect up to 30% of the population and often leads to diabetes and heart disease. Fatty liver disease is a chronic liver condition that often has no symptoms but can lead to serious liver damage. It could affect up to 25% of the population and is common even in people who drink very little alcohol. The rising prevalence of obesity in Australia suggests that the metabolic synd ....The metabolic syndrome is a clustering of obesity, insulin resistance, high cholesterol and high blood pressure. It could affect up to 30% of the population and often leads to diabetes and heart disease. Fatty liver disease is a chronic liver condition that often has no symptoms but can lead to serious liver damage. It could affect up to 25% of the population and is common even in people who drink very little alcohol. The rising prevalence of obesity in Australia suggests that the metabolic syndrome and fatty liver disease may be on the increase and therefore so too could diabetes and heart disease which already consume significant health resources. Using the unique health data collection of the Busselton Health Study in Western Australia, this project will help to determine how common these conditions are in Australia and lead to a better understanding of the nature and causes of these conditions including the possible role of chronic inflammation. This important information will be used to provide opportunities for better risk assessment, disease prevention, and earlier intervention.Read moreRead less
Maternal Health After Childbirth: A Prospective Cohort Study Of 1900 Nulliparous Women Recruited In Early Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$697,150.00
Summary
Recent research highlights a concerning burden of ill health in recent mothers. Common health problems in the year after birth are chronic exhaustion, persisting pain, urinary incontinence, bowel problems, sexual problems and depression. This study will investigate the incidence, onset, severity and duration of health problems in the first 18 months after childbirth. A major focus of the study will be on the extent to which common health problems affecting women after childbirth occur as new pro ....Recent research highlights a concerning burden of ill health in recent mothers. Common health problems in the year after birth are chronic exhaustion, persisting pain, urinary incontinence, bowel problems, sexual problems and depression. This study will investigate the incidence, onset, severity and duration of health problems in the first 18 months after childbirth. A major focus of the study will be on the extent to which common health problems affecting women after childbirth occur as new problems in pregnancy, or after childbirth. This involves following women having a first child and measuring their health in pregnancy and the first year after birth. 1900 women having a first birth will be recruited to the study in early pregnancy, and followed up until 18 months after the birth. A major aim of the study is to provide stronger evidence about the role of pregnancy and birth factors in physical health problems after birth. In particular, the study will examine the contribution of method of delivery to pelvic floor disorders (urinary and anal incontinence, perineal pain and sexual problems). The study will also examine reasons why many women choose not to discuss physical and emotional health problems with health professionals in the postnatal period. The influence of cultural, social and economic factors on health service use and disclosure of maternal health problems will be explored. The study will provide the first Australian data on new health problems experienced for the first time after childbirth, and the extent to which pregnancy, labour and birth contribute to subsequent ill-health. The findings will provide stronger evidence on which to base the care of women during childbirth,development and evaluation of primary and secondary prevention strategies, and information to women and their families regarding the risks of obstetric procedures, such as caesarean section and vaginal birth assisted with forceps.Read moreRead less
Chronic Gastrointestinal Symptoms And Diabetes Mellitus: Risk Factors And Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$271,527.00
Summary
Why many people with diabetes mellitus are afflicted by gastrointestinal (GI) symptoms remains uncertain. Irreversible damage to the nerves controlling the gut (autonomic neuropathy) is often considered to be important. An alternative cause of increased GI symptomatology in diabetics is poor glucose control. Some studies have shown that acute shifts in glucose levels induce changes in the gut relevant to the onset of GI symptoms. For example, high glucose levels acutely cause slower stomach empt ....Why many people with diabetes mellitus are afflicted by gastrointestinal (GI) symptoms remains uncertain. Irreversible damage to the nerves controlling the gut (autonomic neuropathy) is often considered to be important. An alternative cause of increased GI symptomatology in diabetics is poor glucose control. Some studies have shown that acute shifts in glucose levels induce changes in the gut relevant to the onset of GI symptoms. For example, high glucose levels acutely cause slower stomach emptying times, leading to feelings of fullness. Though the effects of chronic glucose levels are yet to be properly explored, population data show that poor control in the long-term is related to an increase in symptoms. The aim of this prospective study is to determine the roles played by both autonomic neuropathy and glucose control in the development of GI symptoms among diabetics. All past research has been cross-sectional, and so cannot tell us if one or both of these factors cause GI problems in diabetes. For example, it is possible that autonomic neuropathy causes an increase in GI symptoms such as nausea and fullness, which in turn induces poor glucose control though lack of appetite or inadequate stomach emptying. Upon study inclusion, all study participants will undergo a series of autonomic tests. At 3 month intervals for a period of 30 months, they will be asked to complete a 2-week diary card detailing their GI symptoms and glucose readings, and also supply blood and urine samples for analysis twice each year. Two years from the study outset, participants will again complete the autonomic test series. Psychiatric co-morbidity will be investigated using the Composite Diagnostic Interview (CIDI-Auto) at the autonomic testing time points. The study will be undertaken at the Gastroenterology Research Unit at Nepean Hospital, in collaboration with the Royal Adelaide Hospital, centres with proven track records in diabetes investigation.Read moreRead less
Collaborative Overview Of Cohort Studies Of Cardiovascular Diseases In The Asia Pacific Region
Funder
National Health and Medical Research Council
Funding Amount
$230,388.00
Summary
Throughout Asia and the Pacific, cardiovascular diseases are now a leading cause of death and disability. However, most information about the causes of these diseases comes from studies conducted in North America and Europe, and there are few data available from the Asia Pacific region. Because patterns of cardiovascular diseases and levels of risk factors are very different in the West and East, it is possible that important differences exist in the relative contribution of different factors to ....Throughout Asia and the Pacific, cardiovascular diseases are now a leading cause of death and disability. However, most information about the causes of these diseases comes from studies conducted in North America and Europe, and there are few data available from the Asia Pacific region. Because patterns of cardiovascular diseases and levels of risk factors are very different in the West and East, it is possible that important differences exist in the relative contribution of different factors to disease occurrence in different regions. For example, an earlier project, from which the current study evolved, demonstrated that the association of blood pressure with stroke was about two times steeper in China and Japan than in the West. The present project has been initiated to further investigate the causes of common cardiovascular diseases in populations of the Asia Pacific region. It will involve more than 40 studies conducted in at least 9 countries from the region. These studies include more than 500,000 individuals followed for an average of 8-9 years. Data from 30 studies involving 450,000 individuals has already been provided to the applicants. Analyses will be conducted to provide region-, age-and sex-specific estimates of the effects various risk factors on several types of cardiovascular diseases. The risk factors of interest include: blood pressure, total cholesterol and its subfractions, triglycerides, diabetes, obesity, alcohol consumption, occupation and education. In addition to providing more precise estimates of the effects of established risk factors such as blood pressure, this project will, provide new data on several other risk factors not well investigated in this region. The results should be of importance in determining priorities for cardiovascular disease prevention. They should also be of relevance for predicting changes in the extent of the cardiovascular disease epidemics facing countries in the region.Read moreRead less
Case-control Studies Of Completed And Attempted Suicide In Young People In NSW
Funder
National Health and Medical Research Council
Funding Amount
$819,000.00
Summary
Youth suicide rates have been increasing dramatically over the last three to four decades. The causes and determinants of these suicide rate changes remain unclear, as do the causes and determinants of the suicides themselves. Despite a range of risk factors being identified by researchers, predicting an individual suicide is difficult due to the range of factors involved and the complex interactions between them. This study will investigate associations between individual and environmental fact ....Youth suicide rates have been increasing dramatically over the last three to four decades. The causes and determinants of these suicide rate changes remain unclear, as do the causes and determinants of the suicides themselves. Despite a range of risk factors being identified by researchers, predicting an individual suicide is difficult due to the range of factors involved and the complex interactions between them. This study will investigate associations between individual and environmental factors for both completed suicides and suicide attempts in young people aged 18-34 years living in NSW. The study will be undertaken in Sydney, Newcastle and in identified rural areas. The study is embedded in existing treatment, counselling and support services and will aid their improvement and augmentation. Cases of suicide and attempted suicide will be compared with community controls, and also completed suicides with attempted suicides, to identify potentially modifiable risk factors associated with suicidal behaviour. This will provide more comprehensive information relating to how various risk factors interact and influence suicidal behaviour, including in rural areas with significant Aboriginal and Torres Strait Islander communities. Information from this study will improve prevention initiatives and assist with community strategic development and provide evidence to enhance current health service and coronial interventions.Read moreRead less