Amplifying Indigenous news: a digital intervention. This project aims to road-test, document and analyse an innovative strategy for amplifying Indigenous voices in news media. The project will deploy and assess the impact of a new digital application designed to enable access to a diverse range of Indigenous voices, stories and agendas. The anticipated outcomes will assist the project’s industry partners meet their strategic goals of increasing the level of Indigenous media representation in Aus ....Amplifying Indigenous news: a digital intervention. This project aims to road-test, document and analyse an innovative strategy for amplifying Indigenous voices in news media. The project will deploy and assess the impact of a new digital application designed to enable access to a diverse range of Indigenous voices, stories and agendas. The anticipated outcomes will assist the project’s industry partners meet their strategic goals of increasing the level of Indigenous media representation in Australia, and consolidate their roles as leading outlets for Indigenous content and coverage. These outcomes are also expected to improve public understanding of issues affecting Indigenous Australians and contribute to more informed and inclusive policy discussions.Read moreRead less
Mobile Indonesians: social differentiation and digital literacies in the twenty first century. This is the first dedicated study of the social implications of mobile telephony's recent and rapid popularisation throughout the country. This project will study metropolitan, urban and rural users to understand how mobile phones create the new and unexpected social networks which will shape tomorrow's Indonesians.
Valuing News: Aligning Individual, Institutional and Societal Perspectives. This project aims to identify the links between the preparedness of individuals to pay for news, the value of news brands and organisational cultures of news publishers, and the social value of news in promoting a democratic public sphere. Its significance arises with the ongoing crisis of news media business models, which is raising new questions about the future of journalism, and the changing role of governments worl ....Valuing News: Aligning Individual, Institutional and Societal Perspectives. This project aims to identify the links between the preparedness of individuals to pay for news, the value of news brands and organisational cultures of news publishers, and the social value of news in promoting a democratic public sphere. Its significance arises with the ongoing crisis of news media business models, which is raising new questions about the future of journalism, and the changing role of governments worldwide in financing news production. Its expected outcomes include advancing debates about how to support public interest journalism, and the value of news as both a commodity and a public good. It will be of benefit to industry, policymakers and the community in addressing the prospects for Australian journalism. Read moreRead less
Intercultural inquiry in a trans-national context: Exploring the legacy of the 1948 American-Australian Scientific Expedition to Arnhem Land. In terms of National Research Priorities, the project will encourage cultural health and cohesiveness in Arnhem Land by providing access to cultural property held until now in remote archives. It will enhance understanding of our region and the world by studying cross-cultural interactions within Australia. Furthermore, it will illuminate how Aboriginal te ....Intercultural inquiry in a trans-national context: Exploring the legacy of the 1948 American-Australian Scientific Expedition to Arnhem Land. In terms of National Research Priorities, the project will encourage cultural health and cohesiveness in Arnhem Land by providing access to cultural property held until now in remote archives. It will enhance understanding of our region and the world by studying cross-cultural interactions within Australia. Furthermore, it will illuminate how Aboriginal territory and knowledge were used to shore up the Australia-US relationship at a formative historical moment.Read moreRead less
Expedition to Arnhem Land: Intercultural inquiry in a trans-national context. In terms of National Research Priorities, the project will encourage cultural health and cohesiveness in Arnhem Land by providing access to cultural property held until now in remote archives. It will enhance understanding of our region and the world by studying cross-cultural interactions within Australia. Furthermore, it will illuminate how Aboriginal territory and knowledge were used to shore up the Australia-US rel ....Expedition to Arnhem Land: Intercultural inquiry in a trans-national context. In terms of National Research Priorities, the project will encourage cultural health and cohesiveness in Arnhem Land by providing access to cultural property held until now in remote archives. It will enhance understanding of our region and the world by studying cross-cultural interactions within Australia. Furthermore, it will illuminate how Aboriginal territory and knowledge were used to shore up the Australia-US relationship at a formative historical moment.Read moreRead less
Breaking silences: media and the Child Abuse Royal Commission. This project aims to analyse the role of media, journalism and social media activism in the Royal Commission into Institutional Responses to Child Sexual Abuse (2013-17) (RCIRCSA). By focusing on the nexus between media and commissions of inquiry in the digital era, the project will investigate the impacts of a rapidly changing media environment on this national 'listening' exercise. The project will use a case study approach to crit ....Breaking silences: media and the Child Abuse Royal Commission. This project aims to analyse the role of media, journalism and social media activism in the Royal Commission into Institutional Responses to Child Sexual Abuse (2013-17) (RCIRCSA). By focusing on the nexus between media and commissions of inquiry in the digital era, the project will investigate the impacts of a rapidly changing media environment on this national 'listening' exercise. The project will use a case study approach to critically analyse the role of a transitioning local, national and social media in triggering, reporting on and keeping alive the findings of the royal commission, ensuring victims of institutional child sexual abuse are heard, and justice is upheld.Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. Inte ....Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. International attention has already resulted in genome characterization of Australian icons (wallaby, Tasmanian devil and platypus), more research on these, and other Australian animals, will further highlight the importance of Australian fauna and impact positively on our scientific profile.Read moreRead less
Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a mo ....Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a model for epigenetic change, and sex chromosomes, which has engaged some of the greatest genetic minds over nearly a century. Therefore my results will attract wide international interest and impact positively on Australia's scientific profile, and further highlight the importance of Australian mammals.Read moreRead less