Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
Rebuilding fiscal federalism in Australia: reforming the financial relationship between the Commonwealth and the States. The finances of the Australian States in the modern day face serious structural challenges. The aim of this project is to analyse and develop appropriate alternatives for reform of fiscal federalism in Australia, which would allow the States to gain access to income tax revenue as a secure source of funding in the future.
Identification And Characterisation Of Novel Genes For Congenital Cataract
Funder
National Health and Medical Research Council
Funding Amount
$432,750.00
Summary
Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Au ....Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Australia over the past 5 years to determine the causative genes. A large number of families have been involved in the study and solid progress has been made in identifying mutations in cataract genes and understanding what effect these may have on the patient's prognosis. We have recently identified a new gene in a large Australian family with a syndrome of cataract, mental retardation and teeth problems. This syndrome, known as Nance-Horan syndrome was originally described in Australia 30 years ago and we have worked with the original family to find the exact gene responsible. We already know that this gene causes the same syndrome in other families and in this project we will examine whether it can cause cataract without the other features or mental retardation without cataract. We will perform a series of experiments to learn what this gene does and how it causes the disease. We have also selected 3 other very interesting families with congenital cataracts for further study as we either know already or strongly suspect that they will enable us to identify further new genes for cataract, and in one case mental retardation. Our work in other diseases indicates that understanding the genes in severe young onset cases can give valuable clues to the causes of age-related forms and may in the future enable new ways to prevent and treat the commonest cause of worldwide blindness.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100074
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
Data Co-operative Platform for Social Impact and Wellbeing. The Data Cooperative (Co-Op) Platform for Social Impact and Wellbeing aims to make data-driven research and decision-making in the social sciences more effective and efficient by developing infrastructure to support data integration and harmonisation of diverse data resources. Social research relies on a vast array of data types and sources, both open and confidential, making data analysis complex and time-consuming. This project will d ....Data Co-operative Platform for Social Impact and Wellbeing. The Data Cooperative (Co-Op) Platform for Social Impact and Wellbeing aims to make data-driven research and decision-making in the social sciences more effective and efficient by developing infrastructure to support data integration and harmonisation of diverse data resources. Social research relies on a vast array of data types and sources, both open and confidential, making data analysis complex and time-consuming. This project will drive innovation across a range of critical social issues that require integrated data for research and social innovation including healthcare, better outcomes for disadvantaged and vulnerable groups, resilient urban, rural and regional communities, and increasing our capacity to respond to climate change. Read moreRead less
An investigation of the impacts of increased power supply to the national grid by wind generators on the Australian electricity industry. The aim of this project is to discover the most economical and effective way to accommodate large increases in wind power into the national grid and to understand the effects on the national electricity market. This is crucial to ensure stability of electricity supply and affordable prices in the transition towards a low carbon economy.