Understanding disease resistance gene evolution across the Brassicaceae. Pan genomes represent the diversity of a species, including structural and sequence variation, which cannot be provided by a reference genome alone. In this project we will characterise resistance gene diversity across the Brassicaceae pan genomes. Through comparison with resistance gene diversity in cultivated Brassica species we will understand selection underlying resistance gene evolution in wild species and subsequent ....Understanding disease resistance gene evolution across the Brassicaceae. Pan genomes represent the diversity of a species, including structural and sequence variation, which cannot be provided by a reference genome alone. In this project we will characterise resistance gene diversity across the Brassicaceae pan genomes. Through comparison with resistance gene diversity in cultivated Brassica species we will understand selection underlying resistance gene evolution in wild species and subsequent domestication and breeding. Knowledge on how variation affects disease susceptibility, especially to the devastating fungal pathogen blackleg, and contributes to phenotypic variation, will lead to improved plant protection strategies and increased crop resilience.Read moreRead less
Fungal Ribosomally Synthesised and Post-translationally Modified Peptides. Fungi produce an array of molecules called secondary metabolites (SMs) that impact on everyday life (e.g. penicillin). This project aims to investigate a new class of fungal peptide SMs called RiPPs which are structurally unique from existing molecules and offer the exciting prospect of harbouring new and novel biological activities. This project expects to discover the mechanisms of RiPP synthesis and their biological ro ....Fungal Ribosomally Synthesised and Post-translationally Modified Peptides. Fungi produce an array of molecules called secondary metabolites (SMs) that impact on everyday life (e.g. penicillin). This project aims to investigate a new class of fungal peptide SMs called RiPPs which are structurally unique from existing molecules and offer the exciting prospect of harbouring new and novel biological activities. This project expects to discover the mechanisms of RiPP synthesis and their biological roles in plant pathogenic fungi, and uncover and engineer novel RiPPs with desired bioactivities. The expected outcome from this project will be a seminal advance in fungal SM biology which should provide significant benefits through the generation of exciting new lead molecules for the agricultural and medical industries.Read moreRead less
Genomics to rust proof the humble oat. This project aims to reduce the impact of the damaging and currently intractable fungal pathogen crown rust (OCR) in Australian oat production. The expected project outcomes are: new sources of enduring high value resistance to OCR, tools to accelerate the use of these resistances, and locally adapted OCR resistant oat germplasm for use in developing profitable oat varieties. The project will use new approaches to tap very recently released genomic resource ....Genomics to rust proof the humble oat. This project aims to reduce the impact of the damaging and currently intractable fungal pathogen crown rust (OCR) in Australian oat production. The expected project outcomes are: new sources of enduring high value resistance to OCR, tools to accelerate the use of these resistances, and locally adapted OCR resistant oat germplasm for use in developing profitable oat varieties. The project will use new approaches to tap very recently released genomic resources and unique oat/ OCR resources assembled over many years. It will lead to responsible stewardship of broadly effective OCR resistance in grazing/milling/hay oats, increasing grower profitability, reducing reliance on fungicides, and underpinning planned growth in our export oat market. Read moreRead less
Ion-atom collision data for fusion energy, hadron therapy and astrophysics. This project aims to combine experimental and theoretical efforts to generate accurate data required for the development and maintenance of fusion reactors, treatment planning in hadron therapy of cancerous tumours, and modelling astrophysical phenomena. Hadron therapy has been used successfully worldwide for over a decade with Australia’s first such facility, the Bragg Centre for Proton Therapy, currently under construc ....Ion-atom collision data for fusion energy, hadron therapy and astrophysics. This project aims to combine experimental and theoretical efforts to generate accurate data required for the development and maintenance of fusion reactors, treatment planning in hadron therapy of cancerous tumours, and modelling astrophysical phenomena. Hadron therapy has been used successfully worldwide for over a decade with Australia’s first such facility, the Bragg Centre for Proton Therapy, currently under construction. Fusion reactors are a source of abundant green energy. Immense progress is being made in their construction and underlying technology. Currently, there is an urgent demand for accurate data on ion-beam collisions with atoms and molecules for the aforementioned applications. This project intends to meet this demand.Read moreRead less
Electron-molecule collisions in fusion and astrophysical plasmas. This project will apply innovative methods developed in Australia to accurately model electron collisions with diatomic hydrides. It will generate new knowledge of the dynamics underlying fundamental chemical reactions, and bring international scientists together to study the influence of molecules in plasmas more accurately than ever before. Outcomes will include essential diagnostics for fusion reactors, methods for using the Ja ....Electron-molecule collisions in fusion and astrophysical plasmas. This project will apply innovative methods developed in Australia to accurately model electron collisions with diatomic hydrides. It will generate new knowledge of the dynamics underlying fundamental chemical reactions, and bring international scientists together to study the influence of molecules in plasmas more accurately than ever before. Outcomes will include essential diagnostics for fusion reactors, methods for using the James Webb Space Telescope to study astrophysical clouds, and strengthened ties between Australia and the global plasma physics community. The significant benefits will include accelerating the development of fusion technology as an alternative to fossil fuels, and furthering our understanding of stellar evolution.Read moreRead less
Antihydrogen formation. This project aims to advance fundamental understanding of collisions involving antimatter. The dominance of matter over antimatter in the Universe is one of the most intriguing questions of today’s science. Researchers at the European Organisation for Nuclear Research (CERN) are addressing this question by creating antihydrogen and studying its properties, including the gravitational behaviour. By trapping and cooling antihydrogen positive ions, ultra-cold antihydrogen at ....Antihydrogen formation. This project aims to advance fundamental understanding of collisions involving antimatter. The dominance of matter over antimatter in the Universe is one of the most intriguing questions of today’s science. Researchers at the European Organisation for Nuclear Research (CERN) are addressing this question by creating antihydrogen and studying its properties, including the gravitational behaviour. By trapping and cooling antihydrogen positive ions, ultra-cold antihydrogen atoms can be created and used in free fall experiments at CERN. The convergent close-coupling method and threshold theory will be used to provide the necessary theoretical guidance for the experimental antihydrogen positive ion formation via low-energy positronium-antiproton and positronium-antihydrogen collisions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100176
Funder
Australian Research Council
Funding Amount
$349,987.00
Summary
Quantum studies of dissociative electron attachment to molecules. The ability to predict the outcomes of molecular collisions is a difficult, yet important, problem with many applications in science and industry. Recent work at Curtin University has led to the first complete solution of the electronic part of the scattering problem for collisions with the hydrogen molecule, a major breakthrough in the field. This project will build on this progress to accurately model the nuclear motion during c ....Quantum studies of dissociative electron attachment to molecules. The ability to predict the outcomes of molecular collisions is a difficult, yet important, problem with many applications in science and industry. Recent work at Curtin University has led to the first complete solution of the electronic part of the scattering problem for collisions with the hydrogen molecule, a major breakthrough in the field. This project will build on this progress to accurately model the nuclear motion during collisions, which will enable the first calculations of molecular dissociation processes without the use of approximations. The data which will be produced is highly sought-after in fusion energy and astrophysics applications.Read moreRead less
Novel biological and genetic disease control tools for the barley industry. This project places Australian barley breeders at the forefront of disease resistance by providing them with novel tools to develop varieties with enhanced protection against fungal diseases. The aims are to produce fungal strains with multiple virulence genes for fast and cost-effective testing of barley lines, untangle the fungal/host gene interaction for resistance breeding and identify new sources of resistance. The ....Novel biological and genetic disease control tools for the barley industry. This project places Australian barley breeders at the forefront of disease resistance by providing them with novel tools to develop varieties with enhanced protection against fungal diseases. The aims are to produce fungal strains with multiple virulence genes for fast and cost-effective testing of barley lines, untangle the fungal/host gene interaction for resistance breeding and identify new sources of resistance. The outcomes will lead to the commercialisation by Australian breeding companies of barley varieties with durable fungal resistance. This will benefit the Australian economy by providing sustainability and protection for barley breeding thereby significantly reducing crop losses for this important global agricultural commodity.Read moreRead less
Electron, positron, and heavy-particle collisions with molecules. This project aims to develop a computational approach to collisions involving molecular targets with electrons, positrons and heavy particles. Recently, the approach to atomic collisions, the Convergent Close Coupling (CCC) method, has been extended and verified for positron, electron, and heavy particle collisions with the simplest molecular systems (molecular hydrogen and its ion). This project now aims to extend the CCC method ....Electron, positron, and heavy-particle collisions with molecules. This project aims to develop a computational approach to collisions involving molecular targets with electrons, positrons and heavy particles. Recently, the approach to atomic collisions, the Convergent Close Coupling (CCC) method, has been extended and verified for positron, electron, and heavy particle collisions with the simplest molecular systems (molecular hydrogen and its ion). This project now aims to extend the CCC method to study collisions with more complex molecules. Expected benefits include more accurate data for diagnostic tools such as Positron Emission Tomography, and potential advances in particle-based cancer therapy.Read moreRead less
Resolving the steps in the evolution of C4 photosynthesis. This project aims to identify the molecular mechanisms responsible for the evolution of grasses using the C4 biochemical pathway that enables plants to survive in hot, dry, high-light environments. The endemic Australian subtribe Neurachninae is the only known grass group that contains C4 species, species using the ancestral C3 pathway, as well as species using pathways intermediate to C3 and C4. Through a comparative approach employing ....Resolving the steps in the evolution of C4 photosynthesis. This project aims to identify the molecular mechanisms responsible for the evolution of grasses using the C4 biochemical pathway that enables plants to survive in hot, dry, high-light environments. The endemic Australian subtribe Neurachninae is the only known grass group that contains C4 species, species using the ancestral C3 pathway, as well as species using pathways intermediate to C3 and C4. Through a comparative approach employing high-throughput sequencing technologies, it is expected that the molecular changes underlying the transition from C3 to C4 will be identified. These results should define what is required to engineer plant varieties with increased yield and the ability to withstand climate change effects.Read moreRead less