Prevention and treatment of chlamydiosis and cryptococcosis in koalas. This project aims to generate increased understanding of the aetiology and pathogenesis of the two most prevalent and debilitating infectious diseases of koalas to make improved decisions regarding therapeutic intervention, prevention and management. Chlamydiosis, caused by two chlamydial bacteria, affects koala fertility, urinary tract function and eyesight. Cryptococcosis, caused by the fungus Cryptococcus gattii, may resul ....Prevention and treatment of chlamydiosis and cryptococcosis in koalas. This project aims to generate increased understanding of the aetiology and pathogenesis of the two most prevalent and debilitating infectious diseases of koalas to make improved decisions regarding therapeutic intervention, prevention and management. Chlamydiosis, caused by two chlamydial bacteria, affects koala fertility, urinary tract function and eyesight. Cryptococcosis, caused by the fungus Cryptococcus gattii, may result in koala morbidity and death. Planned therapeutic trials, prevention strategies and the development of optimal husbandry strategies will provide knowledge that will lead to reduced koala morbidity through improved understanding of the interactions amongst infectious pathogens, the animal host and the environment.Read moreRead less
Establishment of Therapeutically Relevant Animal Models and Markers for Crohn's Disease. Crohn's disease is a devastating life long disease, affecting 0.5% of the world population. There is urgent economic and social need to develop new and better drugs to treat the symptoms and underlying cause of this debilitating disease. Social benefits include the improved quality of life of sufferers that positively impacts society. Economic benefit includes income derived from commercialisation of rese ....Establishment of Therapeutically Relevant Animal Models and Markers for Crohn's Disease. Crohn's disease is a devastating life long disease, affecting 0.5% of the world population. There is urgent economic and social need to develop new and better drugs to treat the symptoms and underlying cause of this debilitating disease. Social benefits include the improved quality of life of sufferers that positively impacts society. Economic benefit includes income derived from commercialisation of research outcomes and the contribution this project makes to high value employment in the biotechnology sector.Read moreRead less
Emergence of a virulent strain of West Nile virus causing fatal equine encephalitis in south-eastern Australia. In 2011 a large outbreak of encephalitis in horses occurred in south-eastern Australia that was caused by a new virus that is transmitted by mosquitoes and is related to West Nile virus, known to cause severe disease in humans and horses. This project will study this new virus and develop improved methods for diagnosis and control of this disease.
ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies ....ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies (CAMS) will bring together key Australian and international scientists to work in this emerging scientific field of antimatter-matter interactions. It will forge a unique and effective scientific team for state-of-the-art studies of the nano-world that underlies many everyday processes and new technologies.Read moreRead less
ARC Centre of Excellence in Plant Cell Wall Biology. The ARC Centre for Plant Cell Wall Biology will define the regulatory mechanisms that control molecular, enzymic and cellular processes involved in the synthesis, deposition, re-modelling and depolymerisation of cell wall polysaccharides of cereals and grasses. Plant cell walls represent the world's largest renewable carbon resource, but the regulatory mechanisms responsible for their synthesis and assembly are not understood. Key distinguishi ....ARC Centre of Excellence in Plant Cell Wall Biology. The ARC Centre for Plant Cell Wall Biology will define the regulatory mechanisms that control molecular, enzymic and cellular processes involved in the synthesis, deposition, re-modelling and depolymerisation of cell wall polysaccharides of cereals and grasses. Plant cell walls represent the world's largest renewable carbon resource, but the regulatory mechanisms responsible for their synthesis and assembly are not understood. Key distinguishing features of the Centre will be the international, integrative, and multidisciplinary approach towards addressing major questions in plant biology, its strategy to leverage ARC funding, and its linkages with potential national and international end-users of the fundamental scientific discoveries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668398
Funder
Australian Research Council
Funding Amount
$177,900.00
Summary
Advanced Microwave Facility for Quantum-Atom Optics. Atoms can be controlled using light in visible and infra-red regions, as well as electromagnetic waves of longer wavelength in the microwave (MW) and radiofrequency (RF) part of the spectrum. We presently use optical radiation to control atoms at the quantum level where they can behave like waves and can interact with light to store and manipulate information. The MW and RF facility will extend our abilities and enable more complete control of ....Advanced Microwave Facility for Quantum-Atom Optics. Atoms can be controlled using light in visible and infra-red regions, as well as electromagnetic waves of longer wavelength in the microwave (MW) and radiofrequency (RF) part of the spectrum. We presently use optical radiation to control atoms at the quantum level where they can behave like waves and can interact with light to store and manipulate information. The MW and RF facility will extend our abilities and enable more complete control of the atoms, which will help us develop the first generation quantum technology. This will enable the creation of quantum devices such as atom lasers, atom interferometers and quantum information networks for communication and ultra-sensitive measurement applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775637
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
An Australian Attosecond Science Facility. The laser facility requested here will provide Australian researchers with the ability to take snapshots of physical and biological processes at unprecedented time resolution. Such a facility will enable Australian researchers to remain competitive and continue to contribute significantly to scientific research on an international scale. The facility will provide excellent training for research higher degree students, preparing them for work in high-tec ....An Australian Attosecond Science Facility. The laser facility requested here will provide Australian researchers with the ability to take snapshots of physical and biological processes at unprecedented time resolution. Such a facility will enable Australian researchers to remain competitive and continue to contribute significantly to scientific research on an international scale. The facility will provide excellent training for research higher degree students, preparing them for work in high-tech industries based on cutting-edge discoveries in physics and biology.Read moreRead less
Mitochondrially targeted anti-cancer drugs modulate the mitochondrial genome. Successful cancer management requires novel therapeutical approaches. This project will test the effect of a new class of compounds that target mitochondria, the powerhouse of the cells, where they suppress expression of mitochondrial genes. By this mechanism, cancers that are resistant to apoptosis induction can be inhibited.
Fundamental physics in distant galaxies. The fundamental constants of Nature are assumed to characterise physics in our entire Universe, but are they really the same everywhere and throughout its entire 14 billion year history? This project will answer this question with the first large-scale, purpose-built observational programme on one of the world's biggest and best telescopes.