Biofocussed Prostate Cancer RadioTherapy (BiRT): A Personalised Approach To Delivering The Right Dose To The Right Place
Funder
National Health and Medical Research Council
Funding Amount
$753,565.00
Summary
We propose a new approach to treating prostate cancer with radiotherapy to move from the standard whole prostate treatment to a personalised treatment that varies radiation intensity throughout the prostate. We will mathematically combine features that influence radiotherapy effect from advanced imaging, clinical and biopsy information. This model will map out the radiotherapy dose required at each part of the prostate, to maximise killing of the cancer whilst minimising harm to normal tissue
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882531
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Quantum Limited Single Atom Detectors. The technology that has shaped our society, solid state diodes, transistors and computer chips is based on our ability to manipulate the average quantum properties of materials such as semiconductors. This physics has been well understood for decades. Many technologies that will shape our societies in this century will be based on our ability to manipulate quantum systems precisely, an area that is the focus of quantum atom optics. The detectors requested i ....Quantum Limited Single Atom Detectors. The technology that has shaped our society, solid state diodes, transistors and computer chips is based on our ability to manipulate the average quantum properties of materials such as semiconductors. This physics has been well understood for decades. Many technologies that will shape our societies in this century will be based on our ability to manipulate quantum systems precisely, an area that is the focus of quantum atom optics. The detectors requested in this proposal will ensure that Australia remains competitive in the technologies that will emerge from the new field of quantum atom optics.Read moreRead less
Australian Centre for Quantum-Atom Optics. The Centre will combine pre-eminent Australian theoretical and experimental research groups in quantum and atom optics to create a powerful network to advance the rapidly developing field of Quantum-Atom Optics. We will exploit the quantum nature of multiple particle quantum states of atoms and photons including entangled light and Bose-Einstein condensates. The Centre will focus on fundamental research, but our long term goal is to underpin and develo ....Australian Centre for Quantum-Atom Optics. The Centre will combine pre-eminent Australian theoretical and experimental research groups in quantum and atom optics to create a powerful network to advance the rapidly developing field of Quantum-Atom Optics. We will exploit the quantum nature of multiple particle quantum states of atoms and photons including entangled light and Bose-Einstein condensates. The Centre will focus on fundamental research, but our long term goal is to underpin and develop the next generation quantum technology. We aim to build a quantum toolbox to enable applications such as the transfer and storage of information for photonics, and precision quantum control of atoms for enhanced atom interferometry.Read moreRead less
Large-scale three dimensional deformation of the lithosphere by subduction and mantle flow. We will be modelling of the dynamics of the Earth's crust and shallow lithosphere in response to the huge stresses created by plate motions. For Australia these stresses are transmitted from the distant plate boundaries, but they have a direct controlling influence on the evolution of the petroleum rich basins of Australia. These basins have reached maturity; further exploration will be in deep water wher ....Large-scale three dimensional deformation of the lithosphere by subduction and mantle flow. We will be modelling of the dynamics of the Earth's crust and shallow lithosphere in response to the huge stresses created by plate motions. For Australia these stresses are transmitted from the distant plate boundaries, but they have a direct controlling influence on the evolution of the petroleum rich basins of Australia. These basins have reached maturity; further exploration will be in deep water where geophysical prospecting methods are unreliable. Model-driven "exploration geodynamics" methods such as those we are developing will be needed to support traditional exploration techniques in these areas.Read moreRead less
Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Molecular Characterisation Of Early Precursor Lesions Of A Novel Ñserrated Pathwayî Of Colorectal Cancer Using Gene Expression And Proteomics.
Funder
National Health and Medical Research Council
Funding Amount
$318,338.00
Summary
In Australia, CRC is the second highest cause of all cancer-related deaths. If detected early, CRC has a high success rate of cure, but a percentage of precursor lesions escape detection and show aggressive clinical behaviour to progress to CRC. These are difficult to diagnosis with existing technologies. We aim to understand the biology behind sessile serrated adenoma pathways and hence enhance early detection, diagnosis and treatments strategies.
Three dimensional computational models of geological basin and hinterland evolution incorporating lithospheric mantle and surface processes. Petroleum exploration in deepwater areas offshore Australia is becoming increasingly important as more accessible, shallow water oil reserves near exhaustion. Geological simulation is an important tool for understanding deep water basins where geophysical imaging techniques are less effective. This project will develop 3D computational models relevant to un ....Three dimensional computational models of geological basin and hinterland evolution incorporating lithospheric mantle and surface processes. Petroleum exploration in deepwater areas offshore Australia is becoming increasingly important as more accessible, shallow water oil reserves near exhaustion. Geological simulation is an important tool for understanding deep water basins where geophysical imaging techniques are less effective. This project will develop 3D computational models relevant to understanding the development and evolution of geological basins and the sediments that fill them. The models will be integrated with available offshore data for potentially prospective Australian basins in the Northwest Shelf and the Southern Australian margin.Read moreRead less
Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics ....Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics to achieve new imaging modalities for time-lapse imaging of fundamental processes at the nano-scale. It will allow increasingly small scale resolution of fundamental processes at the nano-scale.Read moreRead less
Theory and Applications of Computer-Intensive Statistical Methods. The availability of powerful computing equipment has had a dramatic impact on statistical methods and thinking. It has motivated development of novel approaches to data analysis, whose conception
and appreciation, even their application, often demand sophisticated and complex theoretical methods. In this context, the project will develop new approaches to solving non-standard statistical problems. These techniques will eithe ....Theory and Applications of Computer-Intensive Statistical Methods. The availability of powerful computing equipment has had a dramatic impact on statistical methods and thinking. It has motivated development of novel approaches to data analysis, whose conception
and appreciation, even their application, often demand sophisticated and complex theoretical methods. In this context, the project will develop new approaches to solving non-standard statistical problems. These techniques will either have direct application to solving practical problems of national or community concern, or provide a better understanding of the nature of such problems.Read moreRead less
Calibrating Cosmology: The Near-Field Approach to Galaxy Formation. Understanding the formation and evolution of structure in the early Universe continues to elude astronomers. Studying these earliest epochs is the driver for billion-dollar investments like the Next Generation Space Telescope and the Square Kilometre Array (with Australia as a primary partner). Our complementary 'near-field cosmology' project is unique, blending strengths in computational cosmology, stellar nucleosynthesis, and ....Calibrating Cosmology: The Near-Field Approach to Galaxy Formation. Understanding the formation and evolution of structure in the early Universe continues to elude astronomers. Studying these earliest epochs is the driver for billion-dollar investments like the Next Generation Space Telescope and the Square Kilometre Array (with Australia as a primary partner). Our complementary 'near-field cosmology' project is unique, blending strengths in computational cosmology, stellar nucleosynthesis, and optical astronomy, to 'deconstruct' the formation history of the one galaxy with detailed chemical and kinematical information - our own Milky Way. Combining theory and observation, cosmology and nucleosynthesis, we will produce the template for galaxy formation, providing the anchor for 'far-field' cosmology.Read moreRead less