Discovery Early Career Researcher Award - Grant ID: DE160101535
Funder
Australian Research Council
Funding Amount
$363,000.00
Summary
Ancient genomics of Western Australian taxa to inform conservation management. The project aims to apply genomic approaches to infer the genetic health and evolutionary history of three threatened, iconic Western Australian taxa: black cockatoos, ghost bats and woylies. Genomic data provide a powerful lens through which to study species, but the applications of genomic techniques in conservation biology have been sparse. Effective restoration and conservation initiatives require an understanding ....Ancient genomics of Western Australian taxa to inform conservation management. The project aims to apply genomic approaches to infer the genetic health and evolutionary history of three threatened, iconic Western Australian taxa: black cockatoos, ghost bats and woylies. Genomic data provide a powerful lens through which to study species, but the applications of genomic techniques in conservation biology have been sparse. Effective restoration and conservation initiatives require an understanding of species' former population sizes, connectivity and biodiversity. The project seeks to elucidate the population genetic, phylogenetic, and conservation genetic parameters of the three species at the genomic level using DNA isolated from modern and ancient sources (eg museum skins and fossils). The information gained may inform conservation efforts for some of Australia’s endangered biota.Read moreRead less
Synthetic genes as reference standards for biology and biomanufacture. Reference standards are needed to improve the measurement of biology and the reliability of biomanufacturing processes. This project aims to engineer synthetic genes capable of acting as reference standards for DNA, RNA and protein. The synthetic genes can be transcribed into mRNA standards, and translated into protein standards, and be further integrated into living cells to measure internal cellular processes.
The outcomes ....Synthetic genes as reference standards for biology and biomanufacture. Reference standards are needed to improve the measurement of biology and the reliability of biomanufacturing processes. This project aims to engineer synthetic genes capable of acting as reference standards for DNA, RNA and protein. The synthetic genes can be transcribed into mRNA standards, and translated into protein standards, and be further integrated into living cells to measure internal cellular processes.
The outcomes include a unified understanding of gene expression and more accurate next-generation sequencing and mass-spectrophotometry technologies. The synthetic genes also allow standardisation and optimisation of biomanufacturing processes that will produce mRNA and biologics products at a higher purity and lower cost.Read moreRead less