Molecular Epidemiology And High Resolution Surveillance Of Salmonella Enterica Serovar Typhimurium In Australia
Funder
National Health and Medical Research Council
Funding Amount
$583,180.00
Summary
Salmonella typhimurium is a leading cause of the food-borne disease – salmonellosis. It is responsible for considerable morbidity and has an enormous economic cost. Molecular typing is the key to rapidly identify and control outbreaks. This project will employ next generation sequencing technology to develop a new molecular typing scheme. A surveillance system that integrates molecular typing data and epidemiological data will be developed for outbreak investigation and disease prevention.
Australian Ovarian Cancer Study (AOCS): A Multidisciplinary Ovarian Cancer Resource For The Genomic Era
Funder
National Health and Medical Research Council
Funding Amount
$1,404,500.00
Summary
Ovarian cancer is relatively uncommon and is histologically very diverse, making it difficult to analyse ovarian cancer at a molecular level, to identify genetic risk factors, or to understand the interaction of genes and environment. Recognizing that a large collaborative study was the only way to achieve sufficient power to address major translational questions in ovarian cancer, the Australian Ovarian Cancer Study was established and is now the largest study of its kind in the world. This pro ....Ovarian cancer is relatively uncommon and is histologically very diverse, making it difficult to analyse ovarian cancer at a molecular level, to identify genetic risk factors, or to understand the interaction of genes and environment. Recognizing that a large collaborative study was the only way to achieve sufficient power to address major translational questions in ovarian cancer, the Australian Ovarian Cancer Study was established and is now the largest study of its kind in the world. This proposal aims to maintain and add value to this unique resource for ovarian cancer research.Read moreRead less
Biomarkers Of Phenotype, Prognosis And Response To Therapy In Pancreatic Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$105,845.00
Summary
Pancreatic cancer (PC) is the 4th leading cause of cancer deaths in our society. This research is aimed at the discovery of novel biomarkers with the ability to forecast prognosis and response to treatments in patients with PC. Ultimately, this will lead to the “individualisation” of the treatment for each patient, so that the most appropriate therapy could be given to an individual patient. This would significantly improve the overall survival and the quality of life for patients.
Epigenetic Determination Of Neuronal Vulnerability And Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$617,857.00
Summary
Neurons are faced with diverse forms of stress everyday. Neural diseases exacerbate this stress, causing interference to genes that normally allow neurons to function correctly. As a result, neurons die, and severe loss can result in diseases such as dementia. We have discovered new molecular factors in neurons that insulate their genes from stress, thereby protecting neuron function and health. The proposed research will exploit these mechanisms to better protect neurons from disease.
Optimising Temporal Genomic Surveillance Of Salmonella Infections In Australia
Funder
National Health and Medical Research Council
Funding Amount
$763,447.00
Summary
Salmonella is a leading cause of the food-borne disease – salmonellosis. It is responsible for considerable morbidity and has an enormous economic cost. Molecular typing is the key to rapidly identify and control outbreaks. This project will optimise the use of whole genome sequencing for outbreak investigation and long term epidemiology. A surveillance system that integrates genome sequence and epidemiological data will be highly significant for outbreak investigation and disease prevention.
Comparative And Evolutionary Genomics Of Schistosomes –Identifying Genes Associated With Parasitism, And Novel Drug And Vaccine Targets
Funder
National Health and Medical Research Council
Funding Amount
$352,229.00
Summary
Schistosomiasis remains an important cause of human illness and death globally. My project proposes comparative genomics and evolutionary analysis of recently sequenced schistosome taxa and all publicly available flatworm genomes. The study will provide novel insights into identifying gene functions and pathways important for the parasite-host interaction, reveal novel candidate anti-schistosome drug or vaccine targets, and identify genes associated with bladder tumorogenesis in S. haematobium.
Controlling The Development And Function Of Hindbrain Commissures In Vertebrate Animals: The Role Of Robo3 Receptor
Funder
National Health and Medical Research Council
Funding Amount
$393,834.00
Summary
Commissural axons connect and coordinate activity between neurons of the left and right sides of the central nervous system. In the forebrain, formation of commissural axons is determined by guidance factors at the midline between the two hemispheres, and abnormalities in guidance can cause developmental malformations. The aims of this project are to elucidate function of the Robo/Slit family of molecules in regulating axon guidance of commissural neurons, particularly in the corpus callosum.
To Investigate The Role Of ATM Protein In Protecting Against Neurodegeneration
Funder
National Health and Medical Research Council
Funding Amount
$953,662.00
Summary
The overall aim of the project is to employ a rat model to investigate neurodegeneration in patients with ataxia-telangiectasia (A-T). Ataxia-telangiectasia is a complex multisystem disorder characterised by progressive neurological impairment, variable immunodeficiency and cancer predisposition. The rat model recapitulates the neurodegeneration in patients and thus this project will provide important insight into the nature of the defect as well as approaches for the treatment of the disorder.