Using 3D printing technology to develop architecturally-controlled synthetic bone substitutes. With the ageing population, there is increasing demand for synthetic materials that can regenerate bone. However, purely synthetic bone-substitute biomaterials cannot regenerate large bone defects in weight-bearing conditions due to their fragility. This project aims to develop a customisable, biodegradable, biocompatible and mechanically strong and tough scaffold that overcomes this long-standing prob ....Using 3D printing technology to develop architecturally-controlled synthetic bone substitutes. With the ageing population, there is increasing demand for synthetic materials that can regenerate bone. However, purely synthetic bone-substitute biomaterials cannot regenerate large bone defects in weight-bearing conditions due to their fragility. This project aims to develop a customisable, biodegradable, biocompatible and mechanically strong and tough scaffold that overcomes this long-standing problem. The project aims to achieve this by applying an innovative combination of cutting-edge 3D printing technology, advanced computational modelling and design techniques to produce a next-generation bioceramic scaffold with optimised architecture. This approach aims also to enable the possibility of producing custom-made implants for individual requirements.Read moreRead less
The mechanical and electrical behaviour of boron nitride nanotubes: Insight from in-situ transmission electron microscopy investigation. Boron nitride nanotubes are an emerging class of inorganic nanotubes with insulating property, exceptional thermal stability, high thermal conductivity, and superior mechanical properties including ultrahigh strength and elastic modulus which are not possible in conventional materials. This project aims to apply state-of-the-art in-situ transmission electron mi ....The mechanical and electrical behaviour of boron nitride nanotubes: Insight from in-situ transmission electron microscopy investigation. Boron nitride nanotubes are an emerging class of inorganic nanotubes with insulating property, exceptional thermal stability, high thermal conductivity, and superior mechanical properties including ultrahigh strength and elastic modulus which are not possible in conventional materials. This project aims to apply state-of-the-art in-situ transmission electron microscopy techniques to explore the dependence of mechanical properties on size, morphology and structure of boron nitride nanotubes and the effect of mechanical strain on electrical properties, which will provide opportunities for composite materials reinforcement via nanotubes, and tune the electronic and optoelectronic properties of nanotubes via strain engineering.Read moreRead less
Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nan ....Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nanowires through molecular dynamics simulations, empirical interatomic potential, and in situ TEM experiments. Expected outcomes include knowledge of the deformation mechanism of this layered titanate which can be broadened to technologically important layered ceramic materials.Read moreRead less
The effect of structure and size on the mechanical behaviour of III-V semiconductor nanowires. The project aims to apply in-situ deformation transmission electron microscopy to investigate the mechanical behaviour of compound semiconductor nanowires and the effect of structure and geometry on the behaviour. The results will uncover the fundamental mechanical properties of nanowires and will guide the design of nanowire-based devices.
Regulation of DNA synthesis and host evasion by Lentivirus Capsids. This project aims to investigate how a type of virus, exemplified by HIV, can synthesise DNA in the cytoplasm of a host cell, without triggering the cell’s innate immunity when DNA is detected outside the nucleus. It expects to advance understanding of the role of the virus’ protein shell in regulating DNA synthesis during infection. The project outcomes should include enhanced capacity for fundamental virus and cell biology re ....Regulation of DNA synthesis and host evasion by Lentivirus Capsids. This project aims to investigate how a type of virus, exemplified by HIV, can synthesise DNA in the cytoplasm of a host cell, without triggering the cell’s innate immunity when DNA is detected outside the nucleus. It expects to advance understanding of the role of the virus’ protein shell in regulating DNA synthesis during infection. The project outcomes should include enhanced capacity for fundamental virus and cell biology research in Australia. The project anticipates contributing to new tools for delivering genes to cells, benefiting therapeutic and biotechnology applications.Read moreRead less
The control of archaeal cell structure by tubulin-family proteins. The objective of this project is to deliver new insights into the evolution and diversity of cell structure and function. Cell theory has been a cornerstone of biology for over 150 years. Yet how early cells developed into modern forms is still a mystery. The primitive and poorly understood third domain of life, Archaea, could hold clues. Recently, proteins were discovered in archaea that are related to the tubulin proteins of al ....The control of archaeal cell structure by tubulin-family proteins. The objective of this project is to deliver new insights into the evolution and diversity of cell structure and function. Cell theory has been a cornerstone of biology for over 150 years. Yet how early cells developed into modern forms is still a mystery. The primitive and poorly understood third domain of life, Archaea, could hold clues. Recently, proteins were discovered in archaea that are related to the tubulin proteins of all higher organisms, which provide the structural framework of cells essential for survival. This project aims to reveal the basis of how the archaeal tubulin proteins control cell shape in response to environmental change, and to develop a new paradigm for archaeal cell biology. This may find application in Australia's biotechnology industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100274
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Design of alloys over multiple grain scales for improving fatigue performance. The project will significantly improve the development of engineering alloy design with high fatigue resistance and produce important benefits to Australian manufacturing industries. It will also establish new knowledge and capability in modelling fatigue behaviours, thus producing great benefits to many science and engineering fields.
Sustainable wastewater management. This project aims to extract high-value liquid products (medium-chain fatty acids) from wastewater with minimised greenhouse gas emissions and energy consumption, in addition to clean water. Traditional wastewater treatment removes organic carbon and nutrients by using vast amounts of energy and releasing greenhouse gas. However, wastewater is a substantial but largely untapped renewable resource. The intended outcome is to transform wastewater from a troubleso ....Sustainable wastewater management. This project aims to extract high-value liquid products (medium-chain fatty acids) from wastewater with minimised greenhouse gas emissions and energy consumption, in addition to clean water. Traditional wastewater treatment removes organic carbon and nutrients by using vast amounts of energy and releasing greenhouse gas. However, wastewater is a substantial but largely untapped renewable resource. The intended outcome is to transform wastewater from a troublesome pollutant to a valuable resource and reduce carbon footprints.Read moreRead less
Interface structures mediating load transfer between soft and hard tissues. This project aims to develop a novel technology platform to mediate load transfer between synthetic and biological materials with dissimilar mechanical properties, creating an effective interface mechanism. It will generate new knowledge in materials engineering by combining interdisciplinary expertise and state-of-the-art technologies in computational modelling, biomaterials, and additive manufacturing. Expected outcome ....Interface structures mediating load transfer between soft and hard tissues. This project aims to develop a novel technology platform to mediate load transfer between synthetic and biological materials with dissimilar mechanical properties, creating an effective interface mechanism. It will generate new knowledge in materials engineering by combining interdisciplinary expertise and state-of-the-art technologies in computational modelling, biomaterials, and additive manufacturing. Expected outcomes are high-tech ceramic structures optimized to interface effectively between synthetic soft tissues and natural hard tissues. This could ultimately benefit Australian industry engaged in developing next-generation synthetic orthopaedic solutions, providing a significant competitive advantage in an expanding global market.Read moreRead less
Rational Design of Novel Multiferroic Materials for Energy Harvesting and Energy Efficiency. Multiferroics are a class of fundamentally complex materials in which several ferroic orders (for example, ferroelectric and ferromagnetic) coexist. The coupling between their electric and magnetic degrees of freedom is controllable via stress and external fields, thus opening the possibility for breakthrough technological developments. By working at the frontier of complex nanostructured oxide materials ....Rational Design of Novel Multiferroic Materials for Energy Harvesting and Energy Efficiency. Multiferroics are a class of fundamentally complex materials in which several ferroic orders (for example, ferroelectric and ferromagnetic) coexist. The coupling between their electric and magnetic degrees of freedom is controllable via stress and external fields, thus opening the possibility for breakthrough technological developments. By working at the frontier of complex nanostructured oxide materials, this project aims to establish the rational basis for systematic design of novel artificially layered multiferroics, develop accurate and computationally affordable methods to simulate these materials under finite-temperature conditions, and exploit this knowledge to devise likely revolutionary photovoltaic, nanoelectronic and energy conversion applications.Read moreRead less