A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent c ....A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent correlations. It should provide new insights and understanding of the mechanisms of deformability changes of RBCs during stored lifespan. Therefore, it should significantly improve blood storage industry practices in terms of improving RBC storage protocols with preventative ageing strategies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100975
Funder
Australian Research Council
Funding Amount
$415,775.00
Summary
Architectured ceramics to combine strength, toughness, and complex shapes. This project aims to develop ceramics that are simultaneously strong and tough, and to form them into complex shapes without compromising their mechanical properties – major challenges in science and engineering. Inspired by the internal architectures that confer these advantages on natural hard materials, it will produce novel ceramics with rationally-designed, highly-controlled dense architectures by developing a fast, ....Architectured ceramics to combine strength, toughness, and complex shapes. This project aims to develop ceramics that are simultaneously strong and tough, and to form them into complex shapes without compromising their mechanical properties – major challenges in science and engineering. Inspired by the internal architectures that confer these advantages on natural hard materials, it will produce novel ceramics with rationally-designed, highly-controlled dense architectures by developing a fast, scalable and versatile light-based 3D–4D printing technique combined with discrete element modelling. Outcomes will be toughened ceramics and new knowledge on processing-architecture-performance relationships, with significant benefits for biomaterials, defence, transport, high-temperature and aerospace applications.Read moreRead less
Towards autonomous structural safety prognostics: integrating in-situ imaging and predictive modelling. This project aims to advance a scientific basis for autonomous safety prognostics by developing predictive models and in-situ damage imaging principles. Development of this new health prognostic approach will overcome the significant challenge of safety assurance of composite structures in the presence of in-service damage, which is largely hidden.
Baseline-free Methods for Early Damage Diagnosis using Nonlinear Ultrasound. To address the significant limitation of existing non-destructive evaluation techniques in detecting and characterising early damage, this project aims to discover the physical nature of self-generated nonlinear waves by structural damage and to explore its potential for an entirely new class of non-destructive evaluation and structural health monitoring techniques. Major applications are expected to include a baseline- ....Baseline-free Methods for Early Damage Diagnosis using Nonlinear Ultrasound. To address the significant limitation of existing non-destructive evaluation techniques in detecting and characterising early damage, this project aims to discover the physical nature of self-generated nonlinear waves by structural damage and to explore its potential for an entirely new class of non-destructive evaluation and structural health monitoring techniques. Major applications are expected to include a baseline-free structural health monitoring technique capable of detecting and quantifying barely-visible impact damage in advanced composite materials, non-destructive evaluation of structures made by additive manufacturing, and detection of hard-to-inspect locations in unitised structures.Read moreRead less